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Aliases for TRIM37 Gene

Aliases for TRIM37 Gene

  • Tripartite Motif Containing 37 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM37 3 4
  • RING-B-Box-Coiled-Coil Protein 2 3
  • Mulibrey Nanism Protein 3 4
  • POB1 3 4
  • MUL 3 4
  • Tripartite Motif-Containing Protein 37 4
  • E3 Ubiquitin-Protein Ligase TRIM37 3
  • Tripartite Motif-Containing 37 2
  • EC 4
  • KIAA0898 4
  • TEF3 3

External Ids for TRIM37 Gene

Previous HGNC Symbols for TRIM37 Gene

  • MUL

Previous GeneCards Identifiers for TRIM37 Gene

  • GC17M056903
  • GC17M059637
  • GC17M057401
  • GC17M057549
  • GC17M054430
  • GC17M054414
  • GC17M057059
  • GC17M052420

Summaries for TRIM37 Gene

Entrez Gene Summary for TRIM37 Gene

  • This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]

GeneCards Summary for TRIM37 Gene

TRIM37 (Tripartite Motif Containing 37) is a Protein Coding gene. Diseases associated with TRIM37 include Mulibrey Nanism and Emphysematous Cholecystitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin mediated proteolysis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for TRIM37 Gene

  • E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).

Gene Wiki entry for TRIM37 Gene

Additional gene information for TRIM37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM37 Gene

Genomics for TRIM37 Gene

GeneHancer (GH) Regulatory Elements for TRIM37 Gene

Promoters and enhancers for TRIM37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J059151 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 678.4 -49.4 -49369 9.6 CLOCK ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC TRIM37 GC17M059154 SKA2 PRR11 MKS1 NDUFB8P2 TUBD1 RPS6KB1 SMG8 RNFT1
GH17J059105 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 694.5 +0.3 303 2.8 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B TRIM37 ENSG00000224738 PRR11 HEATR6 NDUFB8P2 MKS1 TUBD1 RAD51C SMG8 RNFT1
GH17J059108 Enhancer 0.6 dbSUPER 694.5 -2.0 -1950 1.4 BCOR ZNF362 ZNF384 ZNF501 ZNF121 MLLT1 ZBTB33 ZNF18 TRIM37 ENSG00000224738 GC17M059110
GH17J058658 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.4 +447.9 447911 2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC TEX14 GC17M058661 SRSF1 MKS1 SMG8 TRIM37 RAD51C DHX40 VEZF1 SETP3
GH17J058531 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.2 +572.4 572372 5.9 PKNOX1 FOXA2 SIN3A ETS1 YY1 GLIS2 FOS SP3 RXRA REST SEPT4 TRIM37 RNF43 GC17M058529 SEPT4-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM37 gene promoter:
  • Cart-1
  • p53
  • CUTL1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • ATF6
  • Tal-1
  • E47

Genomic Locations for TRIM37 Gene

Genomic Locations for TRIM37 Gene
124,284 bases
Minus strand
124,284 bases
Minus strand

Genomic View for TRIM37 Gene

Genes around TRIM37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM37 Gene

Proteins for TRIM37 Gene

  • Protein details for TRIM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM37
    Protein Accession:
    Secondary Accessions:
    • A8K0V9
    • A8K8U4
    • A8MZ79
    • B4DGZ3
    • F8WEE6
    • Q7Z3E6
    • Q8IYF7
    • Q8WYF7

    Protein attributes for TRIM37 Gene

    964 amino acids
    Molecular mass:
    107906 Da
    Quaternary structure:
    • Associates with the PRC2/EED-EZH2 complex.
    • Acts as a proto-oncogene via its ability to monoubiquinate Lys-119 of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).
    • Sequence=BAA74921.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM37 Gene

    Alternative splice isoforms for TRIM37 Gene


neXtProt entry for TRIM37 Gene

Post-translational modifications for TRIM37 Gene

No data available for DME Specific Peptides for TRIM37 Gene

Domains & Families for TRIM37 Gene

Gene Families for TRIM37 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM37: view

Function for TRIM37 Gene

Molecular function for TRIM37 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Induction:
Overexpressed in a number of breast cancer cell lines.

Enzyme Numbers (IUBMB) for TRIM37 Gene

Phenotypes From GWAS Catalog for TRIM37 Gene

Gene Ontology (GO) - Molecular Function for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 15885686
GO:0005164 tumor necrosis factor receptor binding IPI 11279055
GO:0005515 protein binding IEA,IPI 11279055
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM37: view
genes like me logo Genes that share phenotypes with TRIM37: view

Human Phenotype Ontology for TRIM37 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for TRIM37 Gene

miRTarBase miRNAs that target TRIM37

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM37 Gene

Localization for TRIM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM37 Gene

Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269 PubMed:15885686}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM37 gene
Compartment Confidence
peroxisome 5
cytosol 5
nucleus 4
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 23769972
GO:0005777 peroxisome IDA,IEA 11938494
GO:0005829 cytosol IDA 11279055
GO:0016235 aggresome IDA 15885686
genes like me logo Genes that share ontologies with TRIM37: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM37 Gene

Pathways & Interactions for TRIM37 Gene

genes like me logo Genes that share pathways with TRIM37: view

Pathways by source for TRIM37 Gene

UniProtKB/Swiss-Prot O94972-TRI37_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 25470042
GO:0006351 transcription, DNA-templated IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 11279055
GO:0035518 histone H2A monoubiquitination IDA 25470042
genes like me logo Genes that share ontologies with TRIM37: view

No data available for SIGNOR curated interactions for TRIM37 Gene

Drugs & Compounds for TRIM37 Gene

No Compound Related Data Available

Transcripts for TRIM37 Gene

Unigene Clusters for TRIM37 Gene

Tripartite motif containing 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM37 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP7: - - - - - -
SP8: -

ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - -
SP9: -

Relevant External Links for TRIM37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM37 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for TRIM37 Gene

This gene is overexpressed in Adipocyte (38.6) and Testis (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM37 Gene

Protein tissue co-expression partners for TRIM37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM37 Gene:


SOURCE GeneReport for Unigene cluster for TRIM37 Gene:


mRNA Expression by UniProt/SwissProt for TRIM37 Gene:

Tissue specificity: Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).

Evidence on tissue expression from TISSUES for TRIM37 Gene

  • Nervous system(5)
  • Blood(3.3)
  • Kidney(2.6)
  • Skin(2.2)
  • Lung(2.1)
  • Eye(2)
  • Heart(2)
  • Intestine(2)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM37 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • sinus
  • skull
  • tongue
  • tooth
  • vocal cord
  • heart
  • heart valve
  • lung
  • kidney
  • liver
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with TRIM37: view

Orthologs for TRIM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM37 34 33
  • 99.65 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
-- 34
  • 77 (a)
(Canis familiaris)
Mammalia TRIM37 34 33
  • 92.72 (n)
(Bos Taurus)
Mammalia TRIM37 34 33
  • 91.22 (n)
(Mus musculus)
Mammalia Trim37 16 34 33
  • 88.75 (n)
(Rattus norvegicus)
Mammalia Trim37 33
  • 88.54 (n)
(Monodelphis domestica)
Mammalia TRIM37 34
  • 82 (a)
(Gallus gallus)
Aves TRIM37 34 33
  • 75.28 (n)
(Anolis carolinensis)
Reptilia TRIM37 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim37 33
  • 70.37 (n)
Str.3537 33
(Danio rerio)
Actinopterygii trim37 34 33
  • 63.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7142 34
  • 63 (a)
Species where no ortholog for TRIM37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM37 Gene

Gene Tree for TRIM37 (if available)
Gene Tree for TRIM37 (if available)
Evolutionary constrained regions (ECRs) for TRIM37: view image

Paralogs for TRIM37 Gene

(1) SIMAP similar genes for TRIM37 Gene using alignment to 10 proteins:

  • A8K0V9_HUMAN
  • J3KS72_HUMAN
  • J3KT32_HUMAN
  • J3KT90_HUMAN
genes like me logo Genes that share paralogs with TRIM37: view

No data available for Paralogs for TRIM37 Gene

Variants for TRIM37 Gene

Sequence variations from dbSNP and Humsavar for TRIM37 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1005332262 uncertain-significance, Mulibrey nanism syndrome 58,999,033(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1056996010 uncertain-significance, Mulibrey nanism syndrome 59,106,600(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1057188700 uncertain-significance, Mulibrey nanism syndrome 58,998,996(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs112762655 uncertain-significance, not specified, Mulibrey nanism syndrome 59,031,925(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs112918162 uncertain-significance, Mulibrey nanism syndrome 58,998,400(-) G/ 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM37 Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
esv2421884 CNV deletion 20811451
esv2675820 CNV deletion 23128226
esv2758699 CNV gain 17122850
esv3554606 CNV deletion 23714750
esv3640900 CNV loss 21293372
esv3640901 CNV loss 21293372
nsv1065063 CNV gain 25217958
nsv1127585 CNV deletion 24896259
nsv1134660 CNV deletion 24896259
nsv507849 OTHER sequence alteration 20534489
nsv510719 CNV deletion 20534489
nsv514855 CNV loss 21397061
nsv828068 CNV loss 20364138
nsv828069 CNV loss 20364138
nsv833499 CNV loss 17160897
nsv9574 CNV loss 18304495
nsv962452 CNV deletion 23825009

Variation tolerance for TRIM37 Gene

Residual Variation Intolerance Score: 6.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM37 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM37 Gene

Disorders for TRIM37 Gene

MalaCards: The human disease database

(14) MalaCards diseases for TRIM37 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mulibrey nanism
  • muscle-liver-brain-eye nanism
emphysematous cholecystitis
  • gaseous pericholecystitis
acid-labile subunit deficiency
  • aclsd
purulent labyrinthitis
  • acute suppurative labyrinthitis
pontiac fever
- elite association - COSMIC cancer census association via MalaCards


  • Mulibrey nanism (MUL) [MIM:253250]: An autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms tumor. {ECO:0000269 PubMed:10888877, ECO:0000269 PubMed:12754710, ECO:0000269 PubMed:15108285, ECO:0000269 PubMed:15885686, ECO:0000269 PubMed:17100991, ECO:0000269 PubMed:17551331, ECO:0000269 PubMed:21865362, ECO:0000269 PubMed:23385855}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIM37

genes like me logo Genes that share disorders with TRIM37: view

No data available for Genatlas for TRIM37 Gene

Publications for TRIM37 Gene

  1. A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy. (PMID: 17551331) Doğanc T … Tekin M (Clinical dysmorphology 2007) 3 4 22 58
  2. Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing. (PMID: 16310976) Hämäläinen RH … Lehesjoki AE (Gene 2006) 3 4 22 58
  3. Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. (PMID: 17100991) Hämäläinen RH … Lehesjoki AE (Clinical genetics 2006) 3 4 22 58
  4. Novel mutations in the TRIM37 gene in Mulibrey Nanism. (PMID: 15108285) Hämäläinen RH … Lehesjoki AE (Human mutation 2004) 3 4 22 58
  5. A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. (PMID: 12754710) Jagiello P … Gencik M (Human mutation 2003) 3 4 22 58

Products for TRIM37 Gene

Sources for TRIM37 Gene

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