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Aliases for MUC7 Gene

Aliases for MUC7 Gene

  • Mucin 7, Secreted 2 3 5
  • Mucin 7, Salivary 2 3
  • Salivary Mucin-7 3 4
  • Apo-MG2 3 4
  • MUC-7 3 4
  • MG2 3 4
  • Mucin-7 3

External Ids for MUC7 Gene

Previous GeneCards Identifiers for MUC7 Gene

  • GC04U990038
  • GC04P071587
  • GC04P071653
  • GC04P071518
  • GC04P071372
  • GC04P067098

Summaries for MUC7 Gene

Entrez Gene Summary for MUC7 Gene

  • This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for MUC7 Gene

MUC7 (Mucin 7, Secreted) is a Protein Coding gene. Diseases associated with MUC7 include Asthma and Chronic Ethmoiditis. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling.

UniProtKB/Swiss-Prot for MUC7 Gene

  • May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

Gene Wiki entry for MUC7 Gene

Additional gene information for MUC7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC7 Gene

Genomics for MUC7 Gene

GeneHancer (GH) Regulatory Elements for MUC7 Gene

Promoters and enhancers for MUC7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I070430 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 MUC7 OPRPN
GH04I070472 Promoter 0.5 EPDnew 550.3 +41.7 41686 0.1 MUC7 AMTN
GH04I070471 Promoter 0.5 EPDnew 550.3 +41.4 41447 0.1 MUC7 AMTN
GH04I070397 Promoter 0.5 EPDnew 0.3 -32.6 -32571 0.1 OPRPN MUC7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MUC7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MUC7 Gene

Genomic Locations for MUC7 Gene
52,506 bases
Plus strand

Genomic View for MUC7 Gene

Genes around MUC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC7 Gene

Proteins for MUC7 Gene

  • Protein details for MUC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9UCD7
    • Q9UCD8

    Protein attributes for MUC7 Gene

    377 amino acids
    Molecular mass:
    39159 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MUC7 Gene

Post-translational modifications for MUC7 Gene

  • N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.
  • Glycosylation at isoforms=97, isoforms=128, Asn135, and Asn146

Other Protein References for MUC7 Gene

No data available for DME Specific Peptides for MUC7 Gene

Domains & Families for MUC7 Gene

Gene Families for MUC7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for MUC7 Gene


Suggested Antigen Peptide Sequences for MUC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC7: view

No data available for UniProtKB/Swiss-Prot for MUC7 Gene

Function for MUC7 Gene

Molecular function for MUC7 Gene

GENATLAS Biochemistry:
mucin 7,salivary,expressed only in bladder cancer during the malignant transformation of bladder urothelium
UniProtKB/Swiss-Prot Function:
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

Phenotypes From GWAS Catalog for MUC7 Gene

Gene Ontology (GO) - Molecular Function for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16203048
genes like me logo Genes that share ontologies with MUC7: view
genes like me logo Genes that share phenotypes with MUC7: view

miRNA for MUC7 Gene

miRTarBase miRNAs that target MUC7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC7 Gene

Localization for MUC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUC7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
golgi apparatus 4
lysosome 1

Gene Ontology (GO) - Cellular Components for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0044218 other organism cell membrane IDA 12543672
GO:0070062 extracellular exosome IDA,HDA 19199708
genes like me logo Genes that share ontologies with MUC7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC7 Gene

Pathways & Interactions for MUC7 Gene

genes like me logo Genes that share pathways with MUC7: view

Gene Ontology (GO) - Biological Process for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0016266 O-glycan processing TAS --
GO:0031640 killing of cells of other organism IDA 12543672
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA 12543672
genes like me logo Genes that share ontologies with MUC7: view

No data available for SIGNOR curated interactions for MUC7 Gene

Drugs & Compounds for MUC7 Gene

(6) Drugs for MUC7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MUC7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MUC7: view

Transcripts for MUC7 Gene

Unigene Clusters for MUC7 Gene

Mucin 7, secreted:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP4: - -
SP5: -

Relevant External Links for MUC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC7 Gene

This gene is overexpressed in Minor Salivary Gland (x52.9).

Protein differential expression in normal tissues from HIPED for MUC7 Gene

This gene is overexpressed in Salivary gland (24.9), Saliva (24.3), Nasal epithelium (9.4), and Skin (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC7 Gene

Protein tissue co-expression partners for MUC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MUC7 Gene:


SOURCE GeneReport for Unigene cluster for MUC7 Gene:


mRNA Expression by UniProt/SwissProt for MUC7 Gene:

Tissue specificity: Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).

Evidence on tissue expression from TISSUES for MUC7 Gene

  • Saliva(4.5)
  • Lung(4.3)
  • Muscle(3.2)
genes like me logo Genes that share expression patterns with MUC7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC7 Gene

Orthologs for MUC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MUC7 33 34
  • 99.06 (n)
(Bos Taurus)
Mammalia MUC7 33
  • 66.84 (n)
(Canis familiaris)
Mammalia LOC102153116 33
  • 63.46 (n)
MUC7 34
  • 44 (a)
Species where no ortholog for MUC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC7 Gene

Gene Tree for MUC7 (if available)
Gene Tree for MUC7 (if available)

Paralogs for MUC7 Gene

No data available for Paralogs for MUC7 Gene

Variants for MUC7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC7 Gene

The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.

Sequence variations from dbSNP and Humsavar for MUC7 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000036887 -- 70,477,366(+) T/C intron_variant
rs1000070932 -- 70,451,896(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000092737 -- 70,477,706(+) G/C intron_variant
rs1000143467 -- 70,471,550(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000170760 -- 70,444,455(+) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MUC7 Gene

Variant ID Type Subtype PubMed ID
esv2727789 CNV deletion 23290073
esv2727790 CNV deletion 23290073
esv2759259 CNV loss 17122850
nsv1012495 CNV gain 25217958
nsv1135942 CNV deletion 24896259
nsv518183 CNV loss 19592680
nsv829964 CNV gain 17160897

Variation tolerance for MUC7 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUC7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for MUC7 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MUC7 Gene - From: HGMD, OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • asthma, susceptibility to
chronic ethmoiditis
  • chronic ethmoid sinusitis
ethmoid sinusitis
  • ethmoidal sinusitis
bladder cancer
  • bladder cancer, somatic
dental caries
  • dental caries extending into pulp
- elite association - COSMIC cancer census association via MalaCards
Search MUC7 in MalaCards View complete list of genes associated with diseases


  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:11378823}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for MUC7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MUC7: view

No data available for Genatlas for MUC7 Gene

Publications for MUC7 Gene

  1. MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function. (PMID: 16759176) Rousseau K … Swallow DM (Annals of human genetics 2006) 3 22 44 58
  2. Genetic polymorphism of MUC7: allele frequencies and association with asthma. (PMID: 11378823) Kirkbride HJ … Swallow DM (European journal of human genetics : EJHG 2001) 3 4 44 58
  3. Structure and chromosomal localization of the human salivary mucin gene, MUC7. (PMID: 8838308) Bobek LA … Levine MJ (Genomics 1996) 2 3 22 58
  4. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). (PMID: 7690757) Bobek LA … Levine MJ (The Journal of biological chemistry 1993) 3 4 22 58
  5. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PMID: 21529783) Heath AC … Montgomery GW (Biological psychiatry 2011) 3 44 58

Products for MUC7 Gene

Sources for MUC7 Gene

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