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Aliases for MST1 Gene

Aliases for MST1 Gene

  • Macrophage Stimulating 1 2 3 5
  • Macrophage-Stimulating Protein 3 4
  • D3F15S2 3 4
  • DNF15S2 3 4
  • HGFL 3 4
  • MSP 3 4
  • Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) 3
  • Hepatocyte Growth Factor-Like Protein Homolog 3
  • Hepatocyte Growth Factor-Like Protein 3
  • Macrophage Stimulatory Protein 4
  • Hepatocyte Growth Factor-Like 2
  • NF15S2 3

External Ids for MST1 Gene

Previous HGNC Symbols for MST1 Gene

  • D3F15S2
  • HGFL
  • DNF15S2

Previous GeneCards Identifiers for MST1 Gene

  • GC03P046385
  • GC03P048678
  • GC03M049575
  • GC03M049681
  • GC03M049696
  • GC03M049730

Summaries for MST1 Gene

Entrez Gene Summary for MST1 Gene

  • The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]

GeneCards Summary for MST1 Gene

MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Cholangitis, Primary Sclerosing and Combat Disorder. Among its related pathways are amb2 Integrin signaling and a6b1 and a6b4 Integrin signaling. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HGF.

Gene Wiki entry for MST1 Gene

Additional gene information for MST1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MST1 Gene

Genomics for MST1 Gene

GeneHancer (GH) Regulatory Elements for MST1 Gene

Promoters and enhancers for MST1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049686 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 659.6 +1.2 1180 4.2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MST1 PIR39139 RNF123 AMT RBM6 QRICH1 CDHR4 AMIGO3 GMPPB IMPDH2
GH03J048896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7 +791.2 791240 3.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC25A20 WDR6 QARS QRICH1 USP19 NME6 MRPS18AP1 ATRIP IP6K2 ZNF589
GH03J049721 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5.9 -34.5 -34545 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 GC03P049723 GMPPB PIR51040 PIR59970 GC03M049732 GC03M049731 INKA1 AMT PHF5EP IP6K1
GH03J049467 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5.7 +219.6 219604 5.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF213 ZNF207 ZNF143 DAG1 AMT ENSG00000235236 WDR6 RBM5 RBM6 QRICH1 IP6K2 LAMB2 NAA80
GH03J049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.5 +669.3 669267 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 GC03M049024 MIR425 NDUFAF3 MIR191 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MST1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MST1 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • SEF-1 (1)

Genomic Locations for MST1 Gene

Genomic Locations for MST1 Gene
chr3:49,683,947-49,689,528
(GRCh38/hg38)
Size:
5,582 bases
Orientation:
Minus strand
chr3:49,721,380-49,726,934
(GRCh37/hg19)
Size:
5,555 bases
Orientation:
Minus strand

Genomic View for MST1 Gene

Genes around MST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MST1 Gene

Proteins for MST1 Gene

  • Protein details for MST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26927-HGFL_HUMAN
    Recommended name:
    Hepatocyte growth factor-like protein
    Protein Accession:
    P26927
    Secondary Accessions:
    • A6NLA3
    • A8MSX3
    • Q13350
    • Q14870
    • Q6GTN4

    Protein attributes for MST1 Gene

    Size:
    711 amino acids
    Molecular mass:
    80320 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).

    Three dimensional structures from OCA and Proteopedia for MST1 Gene

neXtProt entry for MST1 Gene

Post-translational modifications for MST1 Gene

  • Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.
  • Glycosylation at isoforms=615, Asn296, and isoforms=72
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MST1 Gene

Domains & Families for MST1 Gene

Gene Families for MST1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26927

UniProtKB/Swiss-Prot:

HGFL_HUMAN :
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with MST1: view

Function for MST1 Gene

Molecular function for MST1 Gene

GENATLAS Biochemistry:
macrophage stimulating,protein 1,paralog to HGF

Phenotypes From GWAS Catalog for MST1 Gene

Gene Ontology (GO) - Molecular Function for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 22087277
GO:0019899 enzyme binding IEA --
GO:0030971 receptor tyrosine kinase binding IDA 22087277
genes like me logo Genes that share ontologies with MST1: view
genes like me logo Genes that share phenotypes with MST1: view

Human Phenotype Ontology for MST1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MST1 Gene

MGI Knock Outs for MST1:
  • Mst1 Mst1<tm1Jab>
  • Mst1 Mst1<tm1(KOMP)Wtsi>

Animal Model Products

miRNA for MST1 Gene

Clone Products

  • Addgene plasmids for MST1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MST1 Gene

Localization for MST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MST1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MST1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 7508914
GO:0005737 cytoplasm IEA --
GO:0005773 vacuole IEA --
genes like me logo Genes that share ontologies with MST1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MST1 Gene

Pathways & Interactions for MST1 Gene

genes like me logo Genes that share pathways with MST1: view

Pathways by source for MST1 Gene

1 GeneTex pathway for MST1 Gene
2 Reactome pathways for MST1 Gene
1 Qiagen pathway for MST1 Gene

SIGNOR curated interactions for MST1 Gene

Activates:

Gene Ontology (GO) - Biological Process for MST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis IEA --
GO:0007566 embryo implantation IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0010758 regulation of macrophage chemotaxis IEA,IBA --
genes like me logo Genes that share ontologies with MST1: view

Drugs & Compounds for MST1 Gene

(6) Drugs for MST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MST1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MST1: view

Transcripts for MST1 Gene

Unigene Clusters for MST1 Gene

Macrophage stimulating 1 (hepatocyte growth factor-like):
Representative Sequences:

Clone Products

  • Addgene plasmids for MST1

Alternative Splicing Database (ASD) splice patterns (SP) for MST1 Gene

No ASD Table

Relevant External Links for MST1 Gene

GeneLoc Exon Structure for
MST1
ECgene alternative splicing isoforms for
MST1

Expression for MST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MST1 Gene

mRNA differential expression in normal tissues according to GTEx for MST1 Gene

This gene is overexpressed in Liver (x31.7).

Protein differential expression in normal tissues from HIPED for MST1 Gene

This gene is overexpressed in Serum (36.4), Plasma (19.4), and Synovial fluid (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MST1 Gene



Protein tissue co-expression partners for MST1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MST1 Gene:

MST1

SOURCE GeneReport for Unigene cluster for MST1 Gene:

Hs.349110

Evidence on tissue expression from TISSUES for MST1 Gene

  • Liver(4.9)
  • Bone marrow(4.2)
  • Nervous system(4.1)
  • Kidney(3.8)
  • Intestine(3.2)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MST1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • urinary
Regions:
Head and neck:
  • eye
  • head
  • mouth
Abdomen:
  • abdominal wall
  • biliary tract
  • gallbladder
  • kidney
  • liver
  • pancreas
Pelvis:
  • ureter
  • urinary bladder
General:
  • skin
genes like me logo Genes that share expression patterns with MST1: view

No data available for mRNA Expression by UniProt/SwissProt for MST1 Gene

Orthologs for MST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MST1 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MST1 34 33
  • 86.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MST1 34 33
  • 81.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mst1 16 34 33
  • 81.4 (n)
rat
(Rattus norvegicus)
Mammalia Mst1 33
  • 80.83 (n)
oppossum
(Monodelphis domestica)
Mammalia MST1 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MST1 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves MST1 34 33
  • 67.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MST1 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mst1 33
  • 61.72 (n)
Str.2230 33
African clawed frog
(Xenopus laevis)
Amphibia MGC54016 33
zebrafish
(Danio rerio)
Actinopterygii mst1 34 33 33
  • 59.82 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10681 33
fruit fly
(Drosophila melanogaster)
Insecta Tequila 34
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea svh-1 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for MST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MST1 Gene

ENSEMBL:
Gene Tree for MST1 (if available)
TreeFam:
Gene Tree for MST1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MST1: view image

Paralogs for MST1 Gene

Paralogs for MST1 Gene

(33) SIMAP similar genes for MST1 Gene using alignment to 5 proteins:

  • HGFL_HUMAN
  • F5H6L8_HUMAN
  • G3XAK1_HUMAN
  • H7C0F8_HUMAN
  • Q49A61_HUMAN

Pseudogenes.org Pseudogenes for MST1 Gene

genes like me logo Genes that share paralogs with MST1: view

Variants for MST1 Gene

Sequence variations from dbSNP and Humsavar for MST1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs62262686 not-provided, not provided 49,688,637(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000480874 -- 49,690,120(-) G/A upstream_transcript_variant
rs1000575003 -- 49,690,407(-) A/G upstream_transcript_variant
rs1001926363 -- 49,689,596(-) C/G upstream_transcript_variant
rs1002024522 -- 49,689,770(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MST1 Gene

Variant ID Type Subtype PubMed ID
esv28815 CNV gain+loss 19812545
nsv1118699 CNV duplication 24896259
nsv1141429 CNV duplication 24896259
nsv1148681 CNV duplication 26484159
nsv471425 CNV gain 19718026
nsv482080 CNV gain 20164927
nsv508217 CNV deletion 20534489
nsv820990 CNV duplication 20802225
nsv822077 CNV gain 20364138

Variation tolerance for MST1 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MST1 Gene

Human Gene Mutation Database (HGMD)
MST1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MST1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MST1 Gene

Disorders for MST1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MST1 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cholangitis, primary sclerosing
  • psc
combat disorder
  • combat neurosis
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
acute stress disorder
  • traumatic stress disorder
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards
Search MST1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HGFL_HUMAN
  • Note=MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD. {ECO:0000269 PubMed:19079170, ECO:0000269 PubMed:20228799}.

Additional Disease Information for MST1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MST1: view

No data available for Genatlas for MST1 Gene

Publications for MST1 Gene

  1. Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. (PMID: 8393443) Yoshimura T … Leonard EJ (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern DP … Seielstad M (Nature genetics 2010) 3 4 44 58
  3. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. (PMID: 19079170) Goyette P … Rioux JD (Mucosal immunology 2008) 3 4 22 58
  4. Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. (PMID: 1827141) Skeel A … Leonard EJ (The Journal of experimental medicine 1991) 3 4 22 58
  5. Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution. (PMID: 22087277) Gorlatova N … Herzberg O (PloS one 2011) 3 4 58

Products for MST1 Gene

Sources for MST1 Gene

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