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Aliases for DBX2 Gene

Aliases for DBX2 Gene

  • Developing Brain Homeobox 2 2 3 5
  • Developing Brain Homeobox Protein 2 3 4
  • Homeobox Protein DBX2 3

External Ids for DBX2 Gene

Previous GeneCards Identifiers for DBX2 Gene

  • GC12M043697
  • GC12M045408
  • GC12M042436

Summaries for DBX2 Gene

GeneCards Summary for DBX2 Gene

DBX2 (Developing Brain Homeobox 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is DBX1.

Gene Wiki entry for DBX2 Gene

Additional gene information for DBX2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBX2 Gene

Genomics for DBX2 Gene

GeneHancer (GH) Regulatory Elements for DBX2 Gene

Promoters and enhancers for DBX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J044874 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15 +175.1 175101 2.4 SIN3A ZNF2 GLIS2 ZNF213 KLF7 SP3 ZNF488 REST ZNF610 GLIS1 NELL2 DBX2 RACGAP1P GC12M044881 ENSG00000201788 GC12M044853
GH12J044846 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +203.2 203150 2.3 PKNOX1 STAT5A BATF IRF4 SCRT2 EED ETV6 IKZF2 CREM RUNX3 NELL2 DBX2 GC12M044833 GC12M044853
GH12J045076 Enhancer 0.5 ENCODE 19.7 -26.1 -26141 1.5 ATF4 POLR2A NANOG GLIS1 ZNF341 POU5F1 ZNF18 DBX2 NELL2 LOC100533757 ENSG00000257319 GC12P045114
GH12J044851 Enhancer 0.4 dbSUPER 14.2 +198.1 198093 3.1 HLF FEZF1 DBX2 NELL2 GC12M044853 GC12M044833
GH12J045089 Enhancer 0.4 UCNEbase 11.3 -38.9 -38865 0.2 DBX2 LOC100533757 GC12P045114 ENSG00000257319
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBX2 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • POU2F1
  • YY1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for DBX2 Gene

Genomic Locations for DBX2 Gene
chr12:45,014,672-45,051,099
(GRCh38/hg38)
Size:
36,428 bases
Orientation:
Minus strand
chr12:45,408,455-45,444,882
(GRCh37/hg19)
Size:
36,428 bases
Orientation:
Minus strand

Genomic View for DBX2 Gene

Genes around DBX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX2 Gene

Proteins for DBX2 Gene

  • Protein details for DBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG2-DBX2_HUMAN
    Recommended name:
    Homeobox protein DBX2
    Protein Accession:
    Q6ZNG2

    Protein attributes for DBX2 Gene

    Size:
    339 amino acids
    Molecular mass:
    36555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX2 Gene

Post-translational modifications for DBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX2 Gene

Domains & Families for DBX2 Gene

Gene Families for DBX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for DBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNG2

UniProtKB/Swiss-Prot:

DBX2_HUMAN :
  • Belongs to the H2.0 homeobox family.
Family:
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX2: view

Function for DBX2 Gene

Gene Ontology (GO) - Molecular Function for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DBX2: view
genes like me logo Genes that share phenotypes with DBX2: view

Animal Model Products

miRNA for DBX2 Gene

miRTarBase miRNAs that target DBX2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DBX2 Gene

Localization for DBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DBX2 Gene

Pathways & Interactions for DBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with DBX2: view

No data available for Pathways by source and SIGNOR curated interactions for DBX2 Gene

Drugs & Compounds for DBX2 Gene

No Compound Related Data Available

Transcripts for DBX2 Gene

mRNA/cDNA for DBX2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DBX2 Gene

Developing brain homeobox 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBX2 Gene

No ASD Table

Relevant External Links for DBX2 Gene

GeneLoc Exon Structure for
DBX2
ECgene alternative splicing isoforms for
DBX2

Expression for DBX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBX2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0), Brain - Substantia nigra (x5.1), Brain - Hypothalamus (x4.4), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for DBX2 Gene

This gene is overexpressed in Breast (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBX2 Gene



Protein tissue co-expression partners for DBX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DBX2 Gene:

DBX2

SOURCE GeneReport for Unigene cluster for DBX2 Gene:

Hs.302764
genes like me logo Genes that share expression patterns with DBX2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBX2 Gene

Orthologs for DBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DBX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBX2 34 33
  • 98.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DBX2 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBX2 34 33
  • 86.88 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbx2 33
  • 79.51 (n)
mouse
(Mus musculus)
Mammalia Dbx2 16 34 33
  • 79.19 (n)
oppossum
(Monodelphis domestica)
Mammalia DBX2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBX2 34 33
  • 77.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBX2 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbx2 33
  • 63.73 (n)
zebrafish
(Danio rerio)
Actinopterygii dbx2 34
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dbx 34
  • 13 (a)
OneToOne
Species where no ortholog for DBX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBX2 Gene

ENSEMBL:
Gene Tree for DBX2 (if available)
TreeFam:
Gene Tree for DBX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBX2: view image

Paralogs for DBX2 Gene

(7) SIMAP similar genes for DBX2 Gene using alignment to 1 proteins:

  • DBX2_HUMAN
genes like me logo Genes that share paralogs with DBX2: view

Variants for DBX2 Gene

Sequence variations from dbSNP and Humsavar for DBX2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000070887 -- 45,051,784(-) G/ upstream_transcript_variant
rs1000208778 -- 45,047,080(-) T/G intron_variant
rs1000423175 -- 45,034,306(-) C/T intron_variant
rs1000446757 -- 45,039,015(-) T/C intron_variant
rs1000577855 -- 45,042,457(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DBX2 Gene

Variant ID Type Subtype PubMed ID
esv1002864 CNV insertion 20482838
esv1534356 CNV insertion 17803354
esv2404363 CNV deletion 18987734
esv2745836 CNV deletion 23290073
esv2745837 CNV deletion 23290073
esv2745838 CNV deletion 23290073
esv2745839 CNV deletion 23290073
esv2745840 CNV deletion 23290073
esv3580254 CNV loss 25503493
nsv1051285 CNV loss 25217958
nsv1142807 CNV tandem duplication 24896259

Variation tolerance for DBX2 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBX2 Gene

Human Gene Mutation Database (HGMD)
DBX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBX2 Gene

Disorders for DBX2 Gene

Additional Disease Information for DBX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DBX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBX2 Gene

Publications for DBX2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A … Jessell TM (Neuron 2001) 2 3 58
  3. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for DBX2 Gene

Sources for DBX2 Gene

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