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Aliases for ACHE Gene

Aliases for ACHE Gene

  • Acetylcholinesterase (Cartwright Blood Group) 2 3 5
  • Acetylcholinesterase (Yt Blood Group) 2 3
  • Yt Blood Group 2 3
  • Apoptosis-Related Acetylcholinesterase 3
  • Acetylcholinesterase (YT Blood Group) 2
  • Acetylcholinesterase 3
  • EC 4
  • ARACHE 3
  • N-ACHE 3
  • ACEE 3
  • AChE 4
  • YT 3

External Ids for ACHE Gene

Previous HGNC Symbols for ACHE Gene

  • YT

Previous GeneCards Identifiers for ACHE Gene

  • GC07M099022
  • GC07M100085
  • GC07M100099
  • GC07M100132
  • GC07M100325
  • GC07M100487
  • GC07M095117

Summaries for ACHE Gene

Entrez Gene Summary for ACHE Gene

  • Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACHE Gene

ACHE (Acetylcholinesterase (Cartwright Blood Group)) is a Protein Coding gene. Diseases associated with ACHE include Yt Blood Group Antigen and Colonic Pseudo-Obstruction. Among its related pathways are Biogenic Amine Synthesis and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and collagen binding. An important paralog of this gene is BCHE.

UniProtKB/Swiss-Prot for ACHE Gene

  • Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.

Tocris Summary for ACHE Gene

  • Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver.

Gene Wiki entry for ACHE Gene

Additional gene information for ACHE Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACHE Gene

Genomics for ACHE Gene

GeneHancer (GH) Regulatory Elements for ACHE Gene

Promoters and enhancers for ACHE Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100894 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 669.8 +0.6 567 4.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF143 SP3 REST ZNF592 ACHE MOSPD3 ENSG00000242798 PPP1R35 SRRT MEPCE SLC12A9 MUC3A TRIP6 ZNF3
GH07J100873 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.7 +21.7 21668 2.9 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A MEF2D SRRT PIR40651 TRIM4 ZNF3 GIGYF1 PPP1R35 STAG3L5P PCOLCE PILRB ENSG00000242798
GH07J100865 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.9 +29.7 29654 4.3 HDGF PKNOX1 CLOCK ARNT SIN3A ZBTB7B YY1 POLR2B ZNF213 E2F8 TRIP6 MIR6875 ZNF3 ACHE TRIM4 GIGYF1 STAG3L5P RN7SL750P RN7SL416P SRRT
GH07J100886 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 19.7 +7.6 7646 5.2 CLOCK DMAP1 E2F8 ZNF143 ZNF263 SP3 MEF2D GLIS1 NBN NR2C1 GC07M100887 UFSP1 TRIM4 SRRT GIGYF1 PPP1R35 ZNF3 ENSG00000242798 AP4M1 STAG3L5P
GH07J100823 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +69.9 69858 6.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 EPHB4 SLC12A9 ZNF3 TRIM4 GIGYF1 SRRT STAG3L5P ENSG00000242798 PPP1R35 PILRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACHE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACHE gene promoter:
  • TBP
  • Sp1
  • Egr-1

Genomic Locations for ACHE Gene

Genomic Locations for ACHE Gene
6,981 bases
Minus strand
6,980 bases
Minus strand

Genomic View for ACHE Gene

Genes around ACHE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACHE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACHE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACHE Gene

Proteins for ACHE Gene

  • Protein details for ACHE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A4D2E2
    • B7ZKZ0
    • D6W5X7
    • Q16169
    • Q29S23
    • Q2M324
    • Q504V3
    • Q53F46
    • Q86TM9
    • Q86YX9
    • Q9BXP7

    Protein attributes for ACHE Gene

    614 amino acids
    Molecular mass:
    67796 Da
    Quaternary structure:
    • Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.

    Three dimensional structures from OCA and Proteopedia for ACHE Gene

    Alternative splice isoforms for ACHE Gene


neXtProt entry for ACHE Gene

Post-translational modifications for ACHE Gene

  • Glycosylation at Asn495, posLast=381381, and Asn296
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACHE Gene

Domains & Families for ACHE Gene

Gene Families for ACHE Gene

Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with ACHE: view

Function for ACHE Gene

Molecular function for ACHE Gene

UniProtKB/Swiss-Prot Function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetylcholine + H(2)O = choline + acetate.
GENATLAS Biochemistry:

Enzyme Numbers (IUBMB) for ACHE Gene

Phenotypes From GWAS Catalog for ACHE Gene

Gene Ontology (GO) - Molecular Function for ACHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding TAS 11283752
GO:0003990 acetylcholinesterase activity TAS --
GO:0004104 cholinesterase activity IDA 1517212
GO:0005515 protein binding IPI 10800960
GO:0005518 collagen binding IDA 12524166
genes like me logo Genes that share ontologies with ACHE: view
genes like me logo Genes that share phenotypes with ACHE: view

Animal Models for ACHE Gene

MGI Knock Outs for ACHE:

Animal Model Products

miRNA for ACHE Gene

miRTarBase miRNAs that target ACHE

Clone Products

  • Addgene plasmids for ACHE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACHE Gene

Localization for ACHE Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACHE Gene

Cell junction, synapse. Secreted. Cell membrane; Peripheral membrane protein.
Isoform T: Nucleus. Note=Only observed in apoptotic nuclei.
Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACHE gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
golgi apparatus 5
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 2
cytosol 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,TAS 11283752
GO:0005605 basal lamina NAS 16289501
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005794 Golgi apparatus IDA 15454088
genes like me logo Genes that share ontologies with ACHE: view

Pathways & Interactions for ACHE Gene

genes like me logo Genes that share pathways with ACHE: view

Gene Ontology (GO) - Biological Process for ACHE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001507 acetylcholine catabolic process in synaptic cleft NAS 1517212
GO:0001919 regulation of receptor recycling IEA --
GO:0002076 osteoblast development IEP 15454088
GO:0006260 DNA replication TAS 11283752
GO:0006581 acetylcholine catabolic process IDA 1517212
genes like me logo Genes that share ontologies with ACHE: view

No data available for SIGNOR curated interactions for ACHE Gene

Drugs & Compounds for ACHE Gene

(124) Drugs for ACHE Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rivastigmine Approved, Investigational Pharma inhibitor, Target Cholinesterase inhibitor 82
Ambenonium Approved Pharma inhibitor, Target 0
Donepezil Approved Pharma inhibitor, Target 295
Edrophonium Approved Pharma inhibitor, Target 1
Galantamine Approved Pharma inhibitor, Target Acetylcholinesterase inhibitor 106

(82) Additional Compounds for ACHE Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 6-Deoxy-L-mannose
  • L-(+)-Rhamnose
  • L-Mannomethylose
  • L-Rha
  • L-Rhamnose

(4) Tocris Compounds for ACHE Gene

Compound Action Cas Number
Ambenonium dichloride Cholinesterase inhibitor 115-79-7
Phenserine Cholinesterase inhibitor 101246-66-6
Physostigmine hemisulfate Cholinesterase inhibitor 64-47-1
Tacrine hydrochloride Cholinesterase inhibitor 1684-40-8
genes like me logo Genes that share compounds with ACHE: view

Transcripts for ACHE Gene

Unigene Clusters for ACHE Gene

Representative Sequences:

Clone Products

  • Addgene plasmids for ACHE

Alternative Splicing Database (ASD) splice patterns (SP) for ACHE Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8: - - - - -
SP9: -
SP10: - - - - - - -

Relevant External Links for ACHE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACHE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACHE Gene

mRNA differential expression in normal tissues according to GTEx for ACHE Gene

This gene is overexpressed in Brain - Hypothalamus (x8.4), Muscle - Skeletal (x4.3), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for ACHE Gene

This gene is overexpressed in Plasma (25.5), Retina (21.3), Vitreous humor (10.7), and Heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACHE Gene

Protein tissue co-expression partners for ACHE Gene

NURSA nuclear receptor signaling pathways regulating expression of ACHE Gene:


SOURCE GeneReport for Unigene cluster for ACHE Gene:


mRNA Expression by UniProt/SwissProt for ACHE Gene:

Tissue specificity: Isoform H is highly expressed in erythrocytes.

Evidence on tissue expression from TISSUES for ACHE Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Muscle(3.8)
  • Adrenal gland(2.4)
  • Intestine(2.4)
  • Liver(2.4)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with ACHE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACHE Gene

Orthologs for ACHE Gene

This gene was present in the common ancestor of animals.

Orthologs for ACHE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACHE 34 33
  • 99.78 (n)
(Bos Taurus)
Mammalia ACHE 34 33
  • 89.72 (n)
(Canis familiaris)
Mammalia ACHE 34 33
  • 89.63 (n)
(Mus musculus)
Mammalia Ache 16 34 33
  • 84.91 (n)
(Rattus norvegicus)
Mammalia Ache 33
  • 84.69 (n)
(Monodelphis domestica)
Mammalia ACHE 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ACHE 34
  • 76 (a)
(Gallus gallus)
Aves ACHE 33
  • 64.66 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
-- 34
  • 41 (a)
-- 34
  • 40 (a)
-- 34
  • 40 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 39 (a)
-- 34
  • 37 (a)
-- 34
  • 36 (a)
-- 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490673 33
  • 63.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8963 33
(Danio rerio)
Actinopterygii ache 34 33 33
  • 64.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta ACES_ANOGA 33
  • 56.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta Jhe 35
  • 36 (a)
alpha-Est8 35
  • 36 (a)
Est-P 35
  • 35 (a)
CG3841 35
  • 35 (a)
Est-6 35
  • 35 (a)
Ace 34 35
  • 33 (a)
clt 35
  • 32 (a)
CG6414 35
  • 32 (a)
BcDNA:GH05741 35
  • 32 (a)
CG4382 35
  • 31 (a)
alpha-Est7 35
  • 31 (a)
CG6018 35
  • 31 (a)
alpha-Est1 35
  • 31 (a)
Gli 35
  • 31 (a)
alpha-Est10 35
  • 30 (a)
CG10175 35
  • 30 (a)
CG7529 35
  • 30 (a)
alpha-Est5 35
  • 29 (a)
alpha-Est2 35
  • 29 (a)
alpha-Est6 35
  • 29 (a)
alpha-Est9 35
  • 29 (a)
alpha-Est4 35
  • 29 (a)
CG8424 35
  • 29 (a)
CG10339 35
  • 28 (a)
alpha-Est3 35
  • 28 (a)
CG5397 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea ace-1 34 35 33
  • 47.89 (n)
R173.3 35
  • 42 (a)
T07H6.1a 35
  • 37 (a)
B0238.13 35
  • 34 (a)
ace-4 34 35
  • 33 (a)
ace-3 34 35
  • 31 (a)
ace-2 34 35
  • 31 (a)
B0238.1 35
  • 30 (a)
F13H6.3 35
  • 30 (a)
K11G9.1 35
  • 29 (a)
F55D10.3 35
  • 28 (a)
T02B5.3 35
  • 27 (a)
T28C12.4a 35
  • 26 (a)
T28C12.4b 35
  • 26 (a)
T02B5.1 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for ACHE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACHE Gene

Gene Tree for ACHE (if available)
Gene Tree for ACHE (if available)
Evolutionary constrained regions (ECRs) for ACHE: view image

Paralogs for ACHE Gene

Paralogs for ACHE Gene

(15) SIMAP similar genes for ACHE Gene using alignment to 11 proteins:

  • C9J2S3_HUMAN
  • C9JD78_HUMAN
  • D6W5X8_HUMAN
  • F8WD34_HUMAN
  • F8WD68_HUMAN
  • Q13697_HUMAN
genes like me logo Genes that share paralogs with ACHE: view

Variants for ACHE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ACHE Gene

ACHE is responsible for the Yt blood group system [MIM:112100]. The molecular basis of the Yt(a)=Yt1/Yt(b)=Yt2 blood group antigens is a single variation in position 353; His-353 corresponds to Yt(a) and the rare variant with Asn-353 to Yt(b).

Sequence variations from dbSNP and Humsavar for ACHE Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1799805 benign, YT BLOOD GROUP POLYMORPHISM 100,893,176(-) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000084778 -- 100,895,649(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000529033 -- 100,894,767(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1001224035 -- 100,894,919(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001371809 -- 100,890,193(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ACHE Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
esv2759547 CNV gain+loss 17122850
nsv1020837 CNV loss 25217958
nsv1137273 CNV deletion 24896259
nsv482110 CNV gain 20164927
nsv607965 CNV loss 21841781
nsv607966 CNV loss 21841781
nsv607967 CNV loss 21841781
nsv607968 CNV loss 21841781
nsv607969 CNV loss 21841781
nsv607970 CNV loss 21841781
nsv831073 CNV loss 17160897

Variation tolerance for ACHE Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACHE Gene

Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for ACHE Gene

MalaCards: The human disease database

(48) MalaCards diseases for ACHE Gene - From: HGMD, OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
yt blood group antigen
  • cartwright antigen
colonic pseudo-obstruction
  • primary chronic pseudo-obstruction of colon
primary orthostatic hypotension
  • neurogenic orthostatic hypotension
myasthenic syndrome, congenital, 5
  • cms5
vascular dementia
  • multi infarct dementia
- elite association - COSMIC cancer census association via MalaCards
Search ACHE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ACHE

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ACHE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACHE Gene

Publications for ACHE Gene

  1. Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. (PMID: 18780301) Scacchi R … Corbo RM (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
  2. Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. (PMID: 11053835) Kryger G … Sussman JL (Acta crystallographica. Section D, Biological crystallography 2000) 3 4 22 58
  3. Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. (PMID: 8299725) Karpel R … Soreq H (Experimental cell research 1994) 3 4 22 58
  4. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. (PMID: 1517212) Shafferman A … Barak D (The Journal of biological chemistry 1992) 3 4 22 58
  5. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 44 58

Products for ACHE Gene