Aliases for MIA2 Gene
- Melanoma Inhibitory Activity 2 2 3
- CTAGE Family Member 5, ER Export Factor 3 5
- CTAGE5 3 5
- Meningioma Expressed Antigen 6 (Coiled-Coil Proline-Rich) 3
- Cutaneous T-Cell Lymphoma-Associated Antigen 5 3
- Melanoma Inhibitory Activity Protein 2 3
- Meningioma-Expressed Antigen 6/11 3
- CTAGE Family, Member 5 3
External Ids for MIA2 Gene
Previous GeneCards Identifiers for MIA2 Gene
This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]
GeneCards Summary for MIA2 Gene
MIA2 (Melanoma Inhibitory Activity 2) is a Protein Coding gene. Diseases associated with MIA2 include Melanoma and Familial Idiopathic Basal Ganglia Calcification. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. An important paralog of this gene is CTAGE1.
UniProtKB/Swiss-Prot for MIA2 Gene
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity).