Aliases for MEOX2 Gene
External Ids for MEOX2 Gene
Previous HGNC Symbols for MEOX2 Gene
Previous GeneCards Identifiers for MEOX2 Gene
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for MEOX2 Gene
MEOX2 (Mesenchyme Homeobox 2) is a Protein Coding gene. Diseases associated with MEOX2 include Female Stress Incontinence and Low Compliance Bladder. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MEOX1.
UniProtKB/Swiss-Prot for MEOX2 Gene
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.