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Aliases for MDM2 Gene

Aliases for MDM2 Gene

  • MDM2 Proto-Oncogene 2 3 5
  • MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase 2 3
  • Oncoprotein Mdm2 3 4
  • Hdm2 3 4
  • Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) 2
  • Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein 3
  • Mouse Double Minute 2, Human Homolog Of; P53-Binding Protein 2
  • Double Minute 2, Human Homolog Of; P53-Binding Protein 3
  • Mdm2, P53 E3 Ubiquitin Protein Ligase Homolog 3
  • MDM2 Oncogene, E3 Ubiquitin Protein Ligase 3
  • Mdm2 P53 Binding Protein Homolog (Mouse) 2
  • RING-Type E3 Ubiquitin Transferase Mdm2 4
  • E3 Ubiquitin-Protein Ligase Mdm2 3
  • P53-Binding Protein Mdm2 4
  • Double Minute 2 Protein 4
  • EC 2.3.2.27 4
  • ACTFS 3
  • HDMX 3

External Ids for MDM2 Gene

Previous GeneCards Identifiers for MDM2 Gene

  • GC12M068977
  • GC12P069030
  • GC12P068918
  • GC12P067488
  • GC12P069201
  • GC12P066253

Summaries for MDM2 Gene

Entrez Gene Summary for MDM2 Gene

  • This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

CIViC summary for MDM2 Gene

GeneCards Summary for MDM2 Gene

MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Accelerated Tumor Formation and Dedifferentiated Liposarcoma. Among its related pathways are Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity and Gene Expression. Gene Ontology (GO) annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is MDM4.

UniProtKB/Swiss-Prot for MDM2 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).

Tocris Summary for MDM2 Gene

  • Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.

Gene Wiki entry for MDM2 Gene

Additional gene information for MDM2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDM2 Gene

Genomics for MDM2 Gene

GeneHancer (GH) Regulatory Elements for MDM2 Gene

Promoters and enhancers for MDM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J068803 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 658.4 -1.5 -1466 7 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MDM2 LOC100130075 NUP107 CPSF6 KRT8P39 RPL10P12 RAP1B RPL7P42 ENSG00000258140 ENSG00000256273
GH12J068609 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14 -195.5 -195497 6.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RAP1B NUP107 CPSF6 MDM2 KRT8P39 CPM LINC02384 MDM1 RPL10P12 IFNG
GH12J068783 Enhancer 1.4 FANTOM5 Ensembl ENCODE 23.5 -21.7 -21745 5.2 FOXA2 SMAD1 ARID4B FEZF1 DMAP1 YY1 TCF12 SLC30A9 ATF7 RXRA MDM2 RAP1B CPM SLC35E3 LOC100130075 LOC105369820
GH12J069023 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20.9 +216.6 216600 2 MXI1 JUN MAX BRCA1 RAD21 RFX5 YY1 POLR2A EGR1 SMC3 CPSF6 MDM2 YEATS4 FRS2 NUP107 SLC35E3 GC12M069009 GC12M069139
GH12J068685 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -121.3 -121338 3 MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZC3H11A NUP107 LOC100507250 CPSF6 KRT8P39 RPL10P12 MDM2 RPL7P42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MDM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MDM2 gene promoter:
  • AP-1

Genomic Locations for MDM2 Gene

Genomic Locations for MDM2 Gene
chr12:68,808,168-68,850,686
(GRCh38/hg38)
Size:
42,519 bases
Orientation:
Plus strand
chr12:69,201,956-69,239,214
(GRCh37/hg19)
Size:
37,259 bases
Orientation:
Plus strand

Genomic View for MDM2 Gene

Genes around MDM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDM2 Gene

Proteins for MDM2 Gene

  • Protein details for MDM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00987-MDM2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase Mdm2
    Protein Accession:
    Q00987
    Secondary Accessions:
    • A6NL51
    • A8K2S6
    • Q13226
    • Q13297
    • Q13298
    • Q13299
    • Q13300
    • Q13301
    • Q53XW0
    • Q71TW9
    • Q8WYJ1
    • Q8WYJ2
    • Q9UGI3
    • Q9UMT8

    Protein attributes for MDM2 Gene

    Size:
    491 amino acids
    Molecular mass:
    55233 Da
    Quaternary structure:
    • Interacts with p53/TP53, TP73/p73, RBL5 and RP11. Binds specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, RFWD3, USP7, PYHIN1, and RBBP6. Interacts with ARRB1 and ARRB2. Interacts with PSMA3. Found in a trimeric complex with MDM2, MDM4 and USP2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain). Interacts with FHIT. Interacts with RFFL and RNF34; the interaction stabilizes MDM2. Interacts with CDK5RAP3 and CDKN2A/ARF; form a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with MTA1. Interacts with AARB2. Interacts with MTBP. Interacts with PML. Interacts with TBRG1. Interacts with the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11; the interaction is direct, occurs in the nucleoplasm and negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:15195100, PubMed:24120868). Interacts with ADGRB1; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Interacts with RPL23A; this interaction may promote p53/TP53 polyubiquitination (PubMed:26203195).
    • (Microbial infection) Interacts with herpes virus 8 protein v-IRF4.
    • (Microbial infection) Interacts with and ubiquitinates HIV-1 Tat.
    Miscellaneous:
    • MDM2 RING finger mutations that failed to ubiquitinate p53 in vitro did not target p53 for degradation when expressed in cells.

    Three dimensional structures from OCA and Proteopedia for MDM2 Gene

    Alternative splice isoforms for MDM2 Gene

neXtProt entry for MDM2 Gene

Post-translational modifications for MDM2 Gene

  • Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation.
  • Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization.
  • Ubiquitination at posLast=3636
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for MDM2

No data available for DME Specific Peptides for MDM2 Gene

Domains & Families for MDM2 Gene

Gene Families for MDM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MDM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q00987

UniProtKB/Swiss-Prot:

MDM2_HUMAN :
  • Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself.
  • Belongs to the MDM2/MDM4 family.
Domain:
  • Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself.
Family:
  • Belongs to the MDM2/MDM4 family.
genes like me logo Genes that share domains with MDM2: view

Function for MDM2 Gene

Molecular function for MDM2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Induction:
By DNA damage.
GENATLAS Biochemistry:
p53 associated protein 9,(homolog to murine oncogene Mdm2,present on a mouse double minute chromosome),downregulating TP53,acting as an E3 ubiquitin ligase directly transferring ubiquitin and targetting TP53 to proteasome complex for degradation,expressed in different layers of normal skin,amplified in human sarcoma,malignant glioma,angiosarcoma,liposarcoma and anaplastic astrocytoma,and diffuse large B cell lymphoma

Enzyme Numbers (IUBMB) for MDM2 Gene

Phenotypes From GWAS Catalog for MDM2 Gene

Gene Ontology (GO) - Molecular Function for MDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 9529249
GO:0004842 ubiquitin-protein transferase activity IMP 20173098
GO:0005515 protein binding IPI,IEA 7791904
GO:0008097 5S rRNA binding IDA 24120868
GO:0008270 zinc ion binding IDA 10722742
genes like me logo Genes that share ontologies with MDM2: view
genes like me logo Genes that share phenotypes with MDM2: view

Human Phenotype Ontology for MDM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MDM2 Gene

MGI Knock Outs for MDM2:

Animal Model Products

miRNA for MDM2 Gene

miRTarBase miRNAs that target MDM2

Clone Products

  • Addgene plasmids for MDM2

No data available for Transcription Factor Targets and HOMER Transcription for MDM2 Gene

Localization for MDM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDM2 Gene

Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MDM2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP,IEA 15314173
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IMP 11718560
GO:0005737 cytoplasm IMP,IEA 15314173
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MDM2: view

Pathways & Interactions for MDM2 Gene

genes like me logo Genes that share pathways with MDM2: view

SIGNOR curated interactions for MDM2 Gene

Gene Ontology (GO) - Biological Process for MDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 9271120
GO:0001568 blood vessel development IEA --
GO:0001974 blood vessel remodeling IEA --
GO:0002027 regulation of heart rate IEA --
GO:0003170 heart valve development IEA --
genes like me logo Genes that share ontologies with MDM2: view

Drugs & Compounds for MDM2 Gene

(82) Drugs for MDM2 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2430
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Experimental Pharma Target 0
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Experimental Pharma Target 0

(50) Additional Compounds for MDM2 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
Apcin
300815-04-7
RITA
213261-59-7
SKPin C1
432001-69-9
TAME hydrochloride
1784-03-8

(5) Tocris Compounds for MDM2 Gene

Compound Action Cas Number
Apcin Cdc20 inhibitor; inhibits Cdc20-substrate interaction 300815-04-7
NSC 66811 MDM2 antagonist. Disrupts MDM2-p53 interaction 6964-62-1
RITA MDM2-p53 interaction inhibitor 213261-59-7
SKPin C1 Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest 432001-69-9
TAME hydrochloride Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination 1784-03-8
genes like me logo Genes that share compounds with MDM2: view

Transcripts for MDM2 Gene

Unigene Clusters for MDM2 Gene

MDM2 oncogene, E3 ubiquitin protein ligase:
Representative Sequences:

Clone Products

  • Addgene plasmids for MDM2

Alternative Splicing Database (ASD) splice patterns (SP) for MDM2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - - - - - -
SP12: -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - -

Relevant External Links for MDM2 Gene

GeneLoc Exon Structure for
MDM2
ECgene alternative splicing isoforms for
MDM2

Expression for MDM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MDM2 Gene

Protein differential expression in normal tissues from HIPED for MDM2 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MDM2 Gene



Protein tissue co-expression partners for MDM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MDM2 Gene:

MDM2

SOURCE GeneReport for Unigene cluster for MDM2 Gene:

Hs.484551

mRNA Expression by UniProt/SwissProt for MDM2 Gene:

Q00987-MDM2_HUMAN
Tissue specificity: Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.

Evidence on tissue expression from TISSUES for MDM2 Gene

  • Intestine(4.9)
  • Lung(4.3)
  • Nervous system(4.3)
  • Muscle(3.6)
  • Skin(3.6)
  • Bone marrow(3.5)
  • Kidney(3.5)
  • Heart(3.4)
  • Stomach(3.4)
  • Thyroid gland(3.4)
  • Pancreas(3.3)
  • Liver(3.2)
  • Spleen(3.2)
  • Adrenal gland(3.1)
  • Lymph node(3)
  • Gall bladder(2.8)
  • Blood(2.5)
  • Bone(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MDM2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • skull
Thorax:
  • breast
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • intestine
  • kidney
  • large intestine
  • pancreas
  • stomach
Pelvis:
  • pelvis
  • prostate
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • bone marrow
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with MDM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MDM2 Gene

Orthologs for MDM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDM2 34 33
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MDM2 34 33
  • 92.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MDM2 34 33
  • 92.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mdm2 33
  • 82.86 (n)
mouse
(Mus musculus)
Mammalia Mdm2 16 34 33
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia MDM2 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MDM2 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MDM2 34 33
  • 72.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MDM2 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mdm2 33
  • 64.91 (n)
MGC75586 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10885 33
zebrafish
(Danio rerio)
Actinopterygii mdm2 34 33 33
  • 55.18 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for MDM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDM2 Gene

ENSEMBL:
Gene Tree for MDM2 (if available)
TreeFam:
Gene Tree for MDM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MDM2: view image

Paralogs for MDM2 Gene

Paralogs for MDM2 Gene

(10) SIMAP similar genes for MDM2 Gene using alignment to 31 proteins:

  • MDM2_HUMAN
  • A8WFP2_HUMAN
  • D0EKL1_HUMAN
  • E5RHE2_HUMAN
  • E5RJQ0_HUMAN
  • E7EMW5_HUMAN
  • E7EPE2_HUMAN
  • F5GWH7_HUMAN
  • F5GZB0_HUMAN
  • F5GZC3_HUMAN
  • F5H1M7_HUMAN
  • F5H4Q8_HUMAN
  • G3XA89_HUMAN
  • J3KN53_HUMAN
  • J3QST1_HUMAN
  • Q546E6_HUMAN
  • Q8NDV9_HUMAN
  • Q8NDW0_HUMAN
  • Q8NDW1_HUMAN
  • Q8NDW2_HUMAN
  • Q8WYJ3_HUMAN
  • Q96DS0_HUMAN
  • Q96DS1_HUMAN
  • Q96DS2_HUMAN
  • Q96DS3_HUMAN
  • Q96DS4_HUMAN
  • Q96DS5_HUMAN
  • Q9H4C2_HUMAN
  • Q9H4C3_HUMAN
  • Q9H4C4_HUMAN
  • Q9H4C5_HUMAN

Pseudogenes.org Pseudogenes for MDM2 Gene

genes like me logo Genes that share paralogs with MDM2: view

Variants for MDM2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MDM2 Gene

MDM2_HUMAN-Q00987
A polymorphism in the MDM2 promoter is associated with susceptibility to accelerated tumor formation in both hereditary and sporadic cancers [MIM:614401]. It also contributes to susceptibility to Li-Fraumeni syndrome, in patients carrying a TP53 germline mutation.

Sequence variations from dbSNP and Humsavar for MDM2 Gene