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Aliases for SMCP Gene

Aliases for SMCP Gene

  • Sperm Mitochondria Associated Cysteine Rich Protein 2 3 5
  • MCSP 3 4
  • MCS 3 4
  • Sperm Mitochondrial-Associated Cysteine-Rich Protein 3
  • Sperm Mitochondria-Associated Cysteine-Rich Protein 2
  • Mitochondrial Capsule Selenoprotein 2
  • Testicular Tissue Protein Li 119 3
  • Testicular Tissue Protein Li 161 3
  • HSMCSGEN1 3

External Ids for SMCP Gene

Previous HGNC Symbols for SMCP Gene

  • MCSP

Previous GeneCards Identifiers for SMCP Gene

  • GC01P149664
  • GC01P151117
  • GC01P124213

Summaries for SMCP Gene

Entrez Gene Summary for SMCP Gene

  • Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

GeneCards Summary for SMCP Gene

SMCP (Sperm Mitochondria Associated Cysteine Rich Protein) is a Protein Coding gene. Diseases associated with SMCP include Cleft Palate, Isolated and Orofacial Cleft.

UniProtKB/Swiss-Prot for SMCP Gene

  • Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).

Gene Wiki entry for SMCP Gene

Additional gene information for SMCP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCP Gene

Genomics for SMCP Gene

GeneHancer (GH) Regulatory Elements for SMCP Gene

Promoters and enhancers for SMCP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152870 Promoter 0.9 EPDnew 650.4 -8.3 -8276 0.1 CTCF ZNF654 CBFB TRIM22 REST RAD21 XRCC5 FOXK2 ZNF143 SMC3 LOC105371444 SMCP LOC105371445 GC01P152823
GH01J152878 Promoter 0.6 EPDnew 650.7 0.0 -14 0.1 CTCF SMCP LOC105371445 GC01P152823
GH01J152904 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 0.3 +28.4 28385 3.8 PKNOX1 ZBTB21 KLF17 EBF1 BATF IRF4 RELA ZNF335 GATA3 ZNF366 IVL SMCP
GH01J152879 Enhancer 0.6 ENCODE 0.7 +2.2 2206 1.6 CTCF SP1 FOXA2 JUND RXRA EED HNF4A YY1 SMCP IVL GC01P152823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMCP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SMCP gene promoter:
  • AREB6
  • Tal-1
  • E47
  • AP-1
  • c-Fos
  • c-Jun
  • SRF (504 AA)
  • SRF
  • AML1a
  • c-Myc

Genomic Locations for SMCP Gene

Genomic Locations for SMCP Gene
chr1:152,878,317-152,885,047
(GRCh38/hg38)
Size:
6,731 bases
Orientation:
Plus strand
chr1:152,850,793-152,857,523
(GRCh37/hg19)
Size:
6,731 bases
Orientation:
Plus strand

Genomic View for SMCP Gene

Genes around SMCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCP Gene

Proteins for SMCP Gene

  • Protein details for SMCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49901-MCSP_HUMAN
    Recommended name:
    Sperm mitochondrial-associated cysteine-rich protein
    Protein Accession:
    P49901
    Secondary Accessions:
    • Q96A42

    Protein attributes for SMCP Gene

    Size:
    116 amino acids
    Molecular mass:
    12767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCP Gene

Post-translational modifications for SMCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCP Gene

Domains & Families for SMCP Gene

Gene Families for SMCP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SMCP Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCP: view

No data available for UniProtKB/Swiss-Prot for SMCP Gene

Function for SMCP Gene

Molecular function for SMCP Gene

UniProtKB/Swiss-Prot Function:
Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).

Phenotypes From GWAS Catalog for SMCP Gene

Gene Ontology (GO) - Molecular Function for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SMCP: view
genes like me logo Genes that share phenotypes with SMCP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMCP Gene

Localization for SMCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCP Gene

Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMCP gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytosol 3

Gene Ontology (GO) - Cellular Components for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0016020 membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SMCP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMCP Gene

Pathways & Interactions for SMCP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0007341 penetration of zona pellucida ISS --
GO:0030317 flagellated sperm motility ISS --
genes like me logo Genes that share ontologies with SMCP: view

No data available for Pathways by source and SIGNOR curated interactions for SMCP Gene

Drugs & Compounds for SMCP Gene

(2) Drugs for SMCP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SMCP: view

Transcripts for SMCP Gene

mRNA/cDNA for SMCP Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMCP Gene

Sperm mitochondria-associated cysteine-rich protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCP

Alternative Splicing Database (ASD) splice patterns (SP) for SMCP Gene

No ASD Table

Relevant External Links for SMCP Gene

GeneLoc Exon Structure for
SMCP
ECgene alternative splicing isoforms for
SMCP

Expression for SMCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMCP Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for SMCP Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMCP Gene



Protein tissue co-expression partners for SMCP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SMCP Gene:

SMCP

SOURCE GeneReport for Unigene cluster for SMCP Gene:

Hs.111850

mRNA Expression by UniProt/SwissProt for SMCP Gene:

P49901-MCSP_HUMAN
Tissue specificity: Testis. Is selectively expressed in the spermatids of seminiferous tubules.
genes like me logo Genes that share expression patterns with SMCP: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMCP Gene

Orthologs for SMCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMCP 34 33
  • 97.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SMCP 34
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMCP 34
  • 42 (a)
OneToOne
Species where no ortholog for SMCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCP Gene

ENSEMBL:
Gene Tree for SMCP (if available)
TreeFam:
Gene Tree for SMCP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMCP: view image

Paralogs for SMCP Gene

No data available for Paralogs for SMCP Gene

Variants for SMCP Gene

Sequence variations from dbSNP and Humsavar for SMCP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000198380 -- 152,876,705(+) CTCTCTCTCTC/CTCTCTCTCTCTC upstream_transcript_variant
rs1000494176 -- 152,882,578(+) A/G intron_variant
rs1000793199 -- 152,880,950(+) G/A intron_variant
rs1002654064 -- 152,881,176(+) A/G intron_variant
rs1002869448 -- 152,881,454(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SMCP Gene

Variant ID Type Subtype PubMed ID
dgv432n100 CNV gain 25217958
esv2758970 CNV gain+loss 17122850
esv2761937 CNV gain 21179565
esv3587570 CNV gain 21293372
esv7910 CNV gain 19470904
nsv1008447 CNV gain 25217958
nsv1129135 CNV insertion 24896259
nsv547899 CNV gain 21841781
nsv831592 CNV gain 17160897

Variation tolerance for SMCP Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMCP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMCP Gene

Disorders for SMCP Gene

MalaCards: The human disease database

(4) MalaCards diseases for SMCP Gene - From: DISEASES

Disorder Aliases PubMed IDs
cleft palate, isolated
  • cpi
orofacial cleft
physical disorder
  • physical illness
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SMCP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SMCP

genes like me logo Genes that share disorders with SMCP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SMCP Gene

Publications for SMCP Gene

  1. Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). (PMID: 8833144) Aho H … Adham IM (Genomics 1996) 2 3 4 22 58
  2. Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene. (PMID: 16325371) Hawthorne SK … Kleene KC (Genomics 2006) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells. (PMID: 24244262) Takahashi A … Sato N (PloS one 2013) 3 58

Products for SMCP Gene

Sources for SMCP Gene

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