Aliases for MCL1 Gene
External Ids for MCL1 Gene
Previous GeneCards Identifiers for MCL1 Gene
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
GeneCards Summary for MCL1 Gene
MCL1 (MCL1, BCL2 Family Apoptosis Regulator) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Leukemia. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and MicroRNAs in cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH3 domain binding.
UniProtKB/Swiss-Prot for MCL1 Gene
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.