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Aliases for MAP1A Gene

Aliases for MAP1A Gene

  • Microtubule Associated Protein 1A 2 3 5
  • Proliferation-Related Protein P80 3 4
  • MAP-1A 3 4
  • MAP1L 3 4
  • Microtubule-Associated Protein 1A 3
  • MTAP1A 3

External Ids for MAP1A Gene

Previous HGNC Symbols for MAP1A Gene

  • MAP1L

Previous GeneCards Identifiers for MAP1A Gene

  • GC15P039180
  • GC15P036705
  • GC15P041382
  • GC15P041528
  • GC15P041525
  • GC15P041597
  • GC15P043803
  • GC15P020657

Summaries for MAP1A Gene

Entrez Gene Summary for MAP1A Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1A Gene

MAP1A (Microtubule Associated Protein 1A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity and microtubule binding. An important paralog of this gene is MAP1B.

UniProtKB/Swiss-Prot for MAP1A Gene

  • Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Gene Wiki entry for MAP1A Gene

Additional gene information for MAP1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1A Gene

Genomics for MAP1A Gene

GeneHancer (GH) Regulatory Elements for MAP1A Gene

Promoters and enhancers for MAP1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J043508 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654.2 -0.8 -827 3.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 TP53BP1 MAP1A GC15M043498 ZSCAN29 CTDSPL2 ADAL CDAN1 LRRC57 LCMT2 UBR1
GH15J043512 Enhancer 0.3 dbSUPER 650.7 +1.5 1472 0.2 NR2C1 TP53BP1 MAP1A GC15P043517
GH15J043440 Enhancer 1.2 Ensembl ENCODE 15.9 -69.9 -69866 2 HDGF FOXA2 ATF1 ARNT ARID4B SIN3A ZNF2 YY1 E2F8 ARID2 ADAL TGM7 MAP1A TP53BP1 PIR42778 PIR48108
GH15J043513 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.7 +5.4 5391 6.4 HDGF ATF1 GLIS2 ZNF143 ATF7 REST ZNF592 SMARCA4 KDM1A CTCF GC15P043517 ZSCAN29 ADAL MAP1A
GH15J043958 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 1.5 +448.1 448108 1.5 JUND POLR2A JUN FOSL2 REST FOS TP53BP1 MAP1A GC15M043974 PIN4P1 FRMD5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAP1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAP1A gene promoter:
  • c-Jun
  • ATF-2
  • Arnt
  • MAZR
  • AREB6
  • GATA-3
  • NRSF form 1
  • NRSF form 2
  • LHX3b
  • Lhx3a

Genomic Locations for MAP1A Gene

Genomic Locations for MAP1A Gene
20,663 bases
Plus strand
20,663 bases
Plus strand

Genomic View for MAP1A Gene

Genes around MAP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1A Gene

Proteins for MAP1A Gene

  • Protein details for MAP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated protein 1A
    Protein Accession:
    Secondary Accessions:
    • O95643
    • Q12973
    • Q15882
    • Q9UJT4

    Protein attributes for MAP1A Gene

    2803 amino acids
    Molecular mass:
    305485 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity).

    Alternative splice isoforms for MAP1A Gene


neXtProt entry for MAP1A Gene

Post-translational modifications for MAP1A Gene

  • Phosphorylated by CSNK1D.
  • LC2 is generated from MAP1A by proteolytic processing.
  • Ubiquitination at isoforms=2275, isoforms=2192, isoforms=2142, and posLast=105105
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP1A Gene

Domains & Families for MAP1A Gene

Gene Families for MAP1A Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP1A Gene

Suggested Antigen Peptide Sequences for MAP1A Gene

Graphical View of Domain Structure for InterPro Entry



  • The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
  • Belongs to the MAP1 family.
  • The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
  • Belongs to the MAP1 family.
genes like me logo Genes that share domains with MAP1A: view

Function for MAP1A Gene

Molecular function for MAP1A Gene

UniProtKB/Swiss-Prot Function:
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
GENATLAS Biochemistry:
microtubule associated protein 1A,306kDa

Phenotypes From GWAS Catalog for MAP1A Gene

Gene Ontology (GO) - Molecular Function for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005198 structural molecule activity NAS 8812494
GO:0005515 protein binding IPI 12812986
GO:0008017 microtubule binding TAS,IEA 26609151
GO:0008093 cytoskeletal adaptor activity ISS --
genes like me logo Genes that share ontologies with MAP1A: view
genes like me logo Genes that share phenotypes with MAP1A: view

Animal Models for MAP1A Gene

MGI Knock Outs for MAP1A:
  • Map1a Map1a<tm1.2(KOMP)Mbp>

Animal Model Products

miRNA for MAP1A Gene

miRTarBase miRNAs that target MAP1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP1A Gene

Localization for MAP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1A gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
lysosome 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005829 cytosol IBA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 8812494
genes like me logo Genes that share ontologies with MAP1A: view

Pathways & Interactions for MAP1A Gene

SuperPathways for MAP1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007409 axonogenesis IBA --
GO:0007613 memory ISS --
GO:0008306 associative learning ISS --
GO:0016358 dendrite development IBA --
genes like me logo Genes that share ontologies with MAP1A: view

No data available for Pathways by source and SIGNOR curated interactions for MAP1A Gene

Drugs & Compounds for MAP1A Gene

(2) Drugs for MAP1A Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estramustine Approved, Investigational Pharma Target, antagonist 55
genes like me logo Genes that share compounds with MAP1A: view

Transcripts for MAP1A Gene

mRNA/cDNA for MAP1A Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(179) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1A Gene

Microtubule-associated protein 1A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP3: - - -
SP5: - - - - - - - - -

Relevant External Links for MAP1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP1A Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Amygdala (x4.3), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for MAP1A Gene

This gene is overexpressed in Frontal cortex (36.1), Brain (13.2), and Spinal cord (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP1A Gene

Protein tissue co-expression partners for MAP1A Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP1A Gene:


SOURCE GeneReport for Unigene cluster for MAP1A Gene:


mRNA Expression by UniProt/SwissProt for MAP1A Gene:

Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for MAP1A Gene

  • Nervous system(5)
  • Muscle(4.3)
  • Liver(4.2)
  • Eye(2.9)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MAP1A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP1A Gene

Orthologs for MAP1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP1A 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia MAP1A 34 33
  • 88.31 (n)
(Bos Taurus)
Mammalia MAP1A 34 33
  • 85.7 (n)
(Mus musculus)
Mammalia Map1a 16 34 33
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Map1a 33
  • 82.42 (n)
(Monodelphis domestica)
Mammalia MAP1A 34
  • 65 (a)
(Gallus gallus)
Aves MAP1A 34 33
  • 59.76 (n)
(Anolis carolinensis)
Reptilia MAP1A 34
  • 40 (a)
(Danio rerio)
Actinopterygii map1aa 34
  • 56 (a)
map1ab 34
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta futsch 34 35
  • 12 (a)
dp 34
  • 3 (a)
Species where no ortholog for MAP1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1A Gene

Gene Tree for MAP1A (if available)
Gene Tree for MAP1A (if available)
Evolutionary constrained regions (ECRs) for MAP1A: view image

Paralogs for MAP1A Gene

Paralogs for MAP1A Gene

(3) SIMAP similar genes for MAP1A Gene using alignment to 5 proteins:

  • Q504X9_HUMAN
  • Q7Z5F9_HUMAN
genes like me logo Genes that share paralogs with MAP1A: view

Variants for MAP1A Gene

Sequence variations from dbSNP and Humsavar for MAP1A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000015402 -- 43,526,154(+) A/G coding_sequence_variant, missense_variant
rs1000138380 -- 43,518,167(+) A/C intron_variant
rs1000408356 -- 43,511,934(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000468510 -- 43,519,092(+) G/C intron_variant
rs1000489139 -- 43,518,443(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1A Gene

Variant ID Type Subtype PubMed ID
esv2760028 CNV gain+loss 17122850
nsv428304 CNV loss 18775914
nsv437799 CNV loss 16327808
nsv515877 CNV loss 19592680
nsv518707 CNV loss 19592680
nsv832988 CNV loss 17160897

Variation tolerance for MAP1A Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.76; 97.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAP1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1A Gene

Disorders for MAP1A Gene

Additional Disease Information for MAP1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MAP1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1A Gene

Publications for MAP1A Gene

  1. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. (PMID: 7629894) Fukuyama R … Rapoport SI (Journal of neuroscience research 1995) 2 3 4 22 58
  2. Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. (PMID: 8812494) Fink JK … Wilkowski J (Genomics 1996) 3 4 22 58
  3. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PMID: 7806212) Lien LL … Kunkel LM (Genomics 1994) 2 3 22 58
  4. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. (PMID: 19251251) Tomppo L … Peltonen L (Biological psychiatry 2009) 3 44 58
  5. MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site. (PMID: 18419581) Zou B … Ordway RW (The Biochemical journal 2008) 4 22 58

Products for MAP1A Gene

Sources for MAP1A Gene

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