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Aliases for MAOB Gene

Aliases for MAOB Gene

  • Monoamine Oxidase B 2 3 5
  • Monoamine Oxidase Type B 3 4
  • MAO-B 3 4
  • Amine Oxidase [Flavin-Containing] B 3
  • Adrenalin Oxidase 3
  • Tyramine Oxidase 3
  • MAO, Platelet 3
  • MAO, Brain 3
  • EC 4

External Ids for MAOB Gene

Previous GeneCards Identifiers for MAOB Gene

  • GC0XM041637
  • GC0XM041886
  • GC0XM042452
  • GC0XM042671
  • GC0XM043383
  • GC0XM043510
  • GC0XM043625
  • GC0XM041355

Summaries for MAOB Gene

Entrez Gene Summary for MAOB Gene

  • The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAOB Gene

MAOB (Monoamine Oxidase B) is a Protein Coding gene. Diseases associated with MAOB include Norrie Disease and Postencephalitic Parkinson Disease. Among its related pathways are Drug metabolism - cytochrome P450 and Dopamine metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and electron transfer activity. An important paralog of this gene is MAOA.

UniProtKB/Swiss-Prot for MAOB Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Tocris Summary for MAOB Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of MAO have been identified: MAO-A and MAO-B.

Gene Wiki entry for MAOB Gene

Additional gene information for MAOB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOB Gene

Genomics for MAOB Gene

GeneHancer (GH) Regulatory Elements for MAOB Gene

Promoters and enhancers for MAOB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ043877 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +1.9 1884 5.6 THRB RAD21 RARA ETS1 EGR1 SCRT2 CREM HMG20B RXRA SP5 MAOB GC0XM043837
GH0XJ044313 Enhancer 1.4 FANTOM5 Ensembl ENCODE 6.5 -432.3 -432256 3.1 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 NCOA1 REST EFHC2 MAOB RRM2P3
GH0XJ043860 Enhancer 0.6 ENCODE 13.9 +21.0 20952 2.1 ELF3 SOX13 RFX1 NFIA RXRA HLF ETV5 RAD21 SP1 JUND MAOB GC0XM043837
GH0XJ042939 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 5 +937.6 937621 9.8 CBFB JUN EBF1 DPF2 POLR2A ETV6 RUNX3 IKZF2 MAOB LOC105373188 ENSG00000270280
GH0XJ043812 Enhancer 0.4 ENCODE 0.2 +69.0 68950 2.2 CTCF RAD21 GC0XM043837 MAOB MAOA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAOB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAOB gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • AREB6
  • c-Fos
  • Sox5

Genomic Locations for MAOB Gene

Genomic Locations for MAOB Gene
115,866 bases
Minus strand
115,865 bases
Minus strand

Genomic View for MAOB Gene

Genes around MAOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAOB Gene

Proteins for MAOB Gene

  • Protein details for MAOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amine oxidase [flavin-containing] B
    Protein Accession:
    Secondary Accessions:
    • B2R6R3
    • B7Z5H3
    • D3DWC3
    • Q7Z6S2

    Protein attributes for MAOB Gene

    520 amino acids
    Molecular mass:
    58763 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAOB Gene

    Alternative splice isoforms for MAOB Gene


neXtProt entry for MAOB Gene

Post-translational modifications for MAOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAOB Gene

No data available for DME Specific Peptides for MAOB Gene

Domains & Families for MAOB Gene

Gene Families for MAOB Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for MAOB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the flavin monoamine oxidase family.
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOB: view

Function for MAOB Gene

Molecular function for MAOB Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2).
GENATLAS Biochemistry:
monoamine oxidase B

Enzyme Numbers (IUBMB) for MAOB Gene

Phenotypes From GWAS Catalog for MAOB Gene

Gene Ontology (GO) - Molecular Function for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008131 primary amine oxidase activity TAS,IEA --
GO:0009055 electron transfer activity TAS 8602220
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with MAOB: view
genes like me logo Genes that share phenotypes with MAOB: view

Animal Models for MAOB Gene

MGI Knock Outs for MAOB:
  • Maob Maob<tm1Shih>

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAOB Gene

Localization for MAOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOB Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAOB gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 3
peroxisome 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion HDA 20833797
GO:0005740 mitochondrial envelope TAS 7063850
GO:0005741 mitochondrial outer membrane TAS 24252804
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAOB: view

Pathways & Interactions for MAOB Gene

genes like me logo Genes that share pathways with MAOB: view

Gene Ontology (GO) - Biological Process for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009636 response to toxic substance IEA --
GO:0010044 response to aluminum ion IEA --
GO:0010269 response to selenium ion IEA --
GO:0014063 negative regulation of serotonin secretion IEA --
GO:0021762 substantia nigra development HEP 22926577
genes like me logo Genes that share ontologies with MAOB: view

No data available for SIGNOR curated interactions for MAOB Gene

Drugs & Compounds for MAOB Gene

(126) Drugs for MAOB Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma antagonist, Target, inhibitor 267
Moclobemide Approved, Investigational Pharma inhibitor, Target, Target, Enzyme, antagonist 7
Phenelzine Approved Pharma inhibitor, Target, Enzyme, antagonist, substrate 7
Rasagiline Approved Pharma inhibitor, Target 55
Selegiline Approved, Investigational, Vet_approved Pharma inhibitor, Target 27

(87) Additional Compounds for MAOB Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Methyl-1H-imidazole-4-ethanamine
  • 1-Methyl-4-(2-aminoethyl)imidazole
  • 3-Methylhistamine
  • 4-(1-Aminoethyl)-1-methyl-1H-imidazole
  • Methylhistamine
  • 1-amino-1-Phenylethane
  • 1-Phenethylamine
  • alpha-Aminoethylbenzene
  • alpha-Methylbenzenemethanamine
  • alpha-Methylbenzylamine
  • 3,4-Dihydroxymandelic aldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • alpha,3,4-Trihydroxybenzeneacetaldehyde
  • alpha,3,4-Trihydroxyphenylacetaldehyde
  • 2-(3,4-Dihydroxyphenyl)ethanal
  • Protocatechuatealdehyde
  • 3,4-Dihydroxy-benzeneacetaldehyde
  • DHPAA aldehyde

(5) Tocris Compounds for MAOB Gene

Compound Action Cas Number
(R)-(-)-Deprenyl hydrochloride MAO-B inhibitor 14611-52-0
Bifemelane hydrochloride MAO-A and MAO-B inhibitor 62232-46-6
Lazabemide hydrochloride Selective MAO-B inhibitor 103878-83-7
Pirlindole mesylate MAO-A inhibitor 207572-66-5
Tetrindole mesylate MAO-A inhibitor 170964-68-8
genes like me logo Genes that share compounds with MAOB: view

Transcripts for MAOB Gene

mRNA/cDNA for MAOB Gene

Unigene Clusters for MAOB Gene

Monoamine oxidase B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAOB Gene

No ASD Table

Relevant External Links for MAOB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAOB Gene

Protein differential expression in normal tissues from HIPED for MAOB Gene

This gene is overexpressed in Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAOB Gene

Protein tissue co-expression partners for MAOB Gene

NURSA nuclear receptor signaling pathways regulating expression of MAOB Gene:


SOURCE GeneReport for Unigene cluster for MAOB Gene:


Evidence on tissue expression from TISSUES for MAOB Gene

  • Liver(4.7)
  • Nervous system(4.6)
  • Adrenal gland(2.7)
  • Blood(2.7)
  • Kidney(2.7)
  • Heart(2.6)
  • Muscle(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MAOB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAOB Gene

Orthologs for MAOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAOB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAOB 34 33
  • 99.29 (n)
(Canis familiaris)
Mammalia MAOB 34 33
  • 91.79 (n)
(Bos Taurus)
Mammalia MAOB 34 33
  • 90.64 (n)
(Monodelphis domestica)
Mammalia MAOB 34
  • 88 (a)
(Mus musculus)
Mammalia Maob 16 34 33
  • 87.58 (n)
(Rattus norvegicus)
Mammalia Maob 33
  • 86.64 (n)
(Ornithorhynchus anatinus)
Mammalia MAOB 34
  • 75 (a)
(Gallus gallus)
Aves MAOB 34 33
  • 74.57 (n)
(Anolis carolinensis)
Reptilia MAOB 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494267 33
  • 72.96 (n)
(Danio rerio)
Actinopterygii mao 34 33
  • 68.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11797 33
bread mold
(Neurospora crassa)
Ascomycetes NCU05933 33
  • 42.47 (n)
Species where no ortholog for MAOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOB Gene

Gene Tree for MAOB (if available)
Gene Tree for MAOB (if available)
Evolutionary constrained regions (ECRs) for MAOB: view image

Paralogs for MAOB Gene

Paralogs for MAOB Gene

(1) SIMAP similar genes for MAOB Gene using alignment to 4 proteins:

  • B7Z242_HUMAN
  • B7Z5H3_HUMAN
genes like me logo Genes that share paralogs with MAOB: view

Variants for MAOB Gene

Sequence variations from dbSNP and Humsavar for MAOB Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000040857 -- 43,840,102(-) T/C intron_variant
rs1000048335 -- 43,857,291(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000055494 -- 43,801,967(-) G/A intron_variant
rs1000083105 -- 43,824,250(-) G/A intron_variant
rs1000143476 -- 43,848,520(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Variation tolerance for MAOB Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAOB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAOB Gene

Disorders for MAOB Gene

MalaCards: The human disease database

(32) MalaCards diseases for MAOB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
norrie disease
  • nd
postencephalitic parkinson disease
  • postencephalitic parkinsonism
pathological gambling
  • compulsive gambling
atypical depressive disorder
  • atypical depression
hepatic encephalopathy
  • portal-systemic encephalopathy
- elite association - COSMIC cancer census association via MalaCards
Search MAOB in MalaCards View complete list of genes associated with diseases

Genatlas disease for MAOB Gene

monoamine oxidase deficiency

Additional Disease Information for MAOB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAOB: view

No data available for UniProtKB/Swiss-Prot for MAOB Gene

Publications for MAOB Gene

  1. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. (PMID: 19506579) Gassó P … Lafuente A (The pharmacogenomics journal 2009) 3 22 44 58
  2. Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. (PMID: 19657584) Dlugos AM … de Wit H (Journal of neural transmission (Vienna, Austria : 1996) 2009) 3 22 44 58
  3. Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population. (PMID: 18832861) Gassó P … Lafuente A (Neuropsychobiology 2008) 3 22 44 58
  4. Gene-gene interaction between FGF20 and MAOB in Parkinson disease. (PMID: 18205889) Gao X … Martin ER (Annals of human genetics 2008) 3 22 44 58
  5. The monoamine oxidase B gene exhibits significant association to ADHD. (PMID: 17918234) Li J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 44 58

Products for MAOB Gene

Sources for MAOB Gene

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