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Aliases for MARCKS Gene

Aliases for MARCKS Gene

  • Myristoylated Alanine Rich Protein Kinase C Substrate 2 3 5
  • Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS, 80K-L) 2 3
  • Protein Kinase C Substrate, 80 KDa Protein, Light Chain 3 4
  • PRKCSL 3 4
  • PKCSL 3 4
  • MACS 3 4
  • Myristoylated Alanine-Rich C-Kinase Substrate 3
  • Phosphomyristin 3
  • 80K-L Protein 4
  • 80K-L 3

External Ids for MARCKS Gene

Previous HGNC Symbols for MARCKS Gene

  • MACS

Previous GeneCards Identifiers for MARCKS Gene

  • GC06P114013
  • GC06P114201
  • GC06P114224
  • GC06P114285
  • GC06P111756
  • GC06P114179
  • GC06P114189

Summaries for MARCKS Gene

Entrez Gene Summary for MARCKS Gene

  • The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCKS Gene

MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate) is a Protein Coding gene. Diseases associated with MARCKS include Anencephaly and Bipolar Disorder. Among its related pathways are MicroRNAs in cancer and Integration of energy metabolism. Gene Ontology (GO) annotations related to this gene include calmodulin binding and protein kinase C binding.

UniProtKB/Swiss-Prot for MARCKS Gene

  • MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Gene Wiki entry for MARCKS Gene

Additional gene information for MARCKS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCKS Gene

Genomics for MARCKS Gene

GeneHancer (GH) Regulatory Elements for MARCKS Gene

Promoters and enhancers for MARCKS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J113854 Promoter/Enhancer 3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.2 +0.5 485 7.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 MARCKS FLJ34503 RPS27AP11 HDAC2 GC06P113861
GH06J113641 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -213.3 -213345 5.4 FOXA2 SMAD1 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF207 FOS MARCKS LINC02541 GC06P113618 GC06M113638
GH06J113629 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -224.8 -224834 7 HDGF PKNOX1 FOXA2 SMAD1 SIN3A IRF4 YY1 ZNF207 ZNF143 ATF7 LINC02541 MARCKS GC06P113618
GH06J113653 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -202.8 -202811 1.7 FOXA2 MAX SIN3A EBF1 RAD21 YY1 POLR2A EED FOSL2 IKZF2 MARCKS LINC02541 GC06M113638
GH06J113762 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.2 -93.8 -93752 2 ESRRA EBF1 BATF IRF4 RELA YY1 GATA3 ZNF239 EED ETV6 MARCKS FLJ34503 GC06P113730 GC06M113782
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MARCKS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MARCKS gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • GATA-2
  • MyoD
  • YY1
  • GATA-1
  • FOXO4
  • GATA-3

Genomic Locations for MARCKS Gene

Genomic Locations for MARCKS Gene
6,141 bases
Plus strand
6,126 bases
Plus strand

Genomic View for MARCKS Gene

Genes around MARCKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCKS Gene

Proteins for MARCKS Gene

  • Protein details for MARCKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myristoylated alanine-rich C-kinase substrate
    Protein Accession:
    Secondary Accessions:
    • E1P560
    • Q2LA83
    • Q5TDB7

    Protein attributes for MARCKS Gene

    332 amino acids
    Molecular mass:
    31555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MARCKS Gene

Post-translational modifications for MARCKS Gene

  • Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MARCKS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MARCKS Gene

Domains & Families for MARCKS Gene

Gene Families for MARCKS Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MARCKS Gene

Suggested Antigen Peptide Sequences for MARCKS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MARCKS family.
  • Belongs to the MARCKS family.
genes like me logo Genes that share domains with MARCKS: view

Function for MARCKS Gene

Molecular function for MARCKS Gene

UniProtKB/Swiss-Prot Function:
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Gene Ontology (GO) - Molecular Function for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005516 calmodulin binding IEA,TAS --
GO:0042802 identical protein binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with MARCKS: view
genes like me logo Genes that share phenotypes with MARCKS: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MARCKS Gene

Localization for MARCKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCKS Gene

Cytoplasm, cytoskeleton. Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MARCKS gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with MARCKS: view

Pathways & Interactions for MARCKS Gene

genes like me logo Genes that share pathways with MARCKS: view

Pathways by source for MARCKS Gene

Interacting Proteins for MARCKS Gene

SIGNOR curated interactions for MARCKS Gene

Other effect:

Gene Ontology (GO) - Biological Process for MARCKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050796 regulation of insulin secretion TAS --
GO:0051017 actin filament bundle assembly IEA --
GO:0051260 protein homooligomerization IEA --
GO:0051764 actin crosslink formation IEA --
genes like me logo Genes that share ontologies with MARCKS: view

Drugs & Compounds for MARCKS Gene

(26) Drugs for MARCKS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(20) Additional Compounds for MARCKS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCKS: view

Transcripts for MARCKS Gene


(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(585) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MARCKS Gene

Myristoylated alanine-rich protein kinase C substrate:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MARCKS Gene

No ASD Table

Relevant External Links for MARCKS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCKS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MARCKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MARCKS Gene

This gene is overexpressed in Cerebral cortex (11.3), Lavage (10.1), Frontal cortex (7.5), Fetal Brain (7.2), and Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MARCKS Gene

Protein tissue co-expression partners for MARCKS Gene

NURSA nuclear receptor signaling pathways regulating expression of MARCKS Gene:


SOURCE GeneReport for Unigene cluster for MARCKS Gene:


Evidence on tissue expression from TISSUES for MARCKS Gene

  • Nervous system(5)
  • Liver(4.5)
  • Lung(4.2)
  • Skin(3.2)
  • Heart(3.1)
  • Pancreas(3.1)
  • Stomach(3.1)
  • Intestine(3)
  • Muscle(3)
  • Eye(2.9)
  • Kidney(2.7)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with MARCKS: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MARCKS Gene

Orthologs for MARCKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCKS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MARCKS 33
  • 99.4 (n)
(Bos Taurus)
Mammalia MARCKS 33
  • 83.59 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8766 33
African clawed frog
(Xenopus laevis)
Amphibia marcks-prov 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10160 33
Species where no ortholog for MARCKS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MARCKS Gene

Gene Tree for MARCKS (if available)
Gene Tree for MARCKS (if available)
Evolutionary constrained regions (ECRs) for MARCKS: view image

Paralogs for MARCKS Gene

No data available for Paralogs for MARCKS Gene

Variants for MARCKS Gene

Sequence variations from dbSNP and Humsavar for MARCKS Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000003869 -- 113,859,420(+) C/A intron_variant
rs1000062533 -- 113,859,864(+) CCCCC/CC/CCCC coding_sequence_variant, frameshift, inframe_deletion
rs1000096795 -- 113,859,610(+) G/A intron_variant
rs1000220930 -- 113,863,382(+) C/A 3_prime_UTR_variant
rs1001274333 -- 113,860,188(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MARCKS Gene

Variant ID Type Subtype PubMed ID
nsv1126755 CNV deletion 24896259
nsv482098 CNV loss 20164927
nsv965756 CNV duplication 23825009

Variation tolerance for MARCKS Gene

Gene Damage Index Score: 2.40; 42.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MARCKS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MARCKS Gene

Disorders for MARCKS Gene

MalaCards: The human disease database

(3) MalaCards diseases for MARCKS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • anph
bipolar disorder
  • major affective disorder 1
spinocerebellar ataxia 14
  • sca14
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MARCKS

genes like me logo Genes that share disorders with MARCKS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCKS Gene

Publications for MARCKS Gene

  1. PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. (PMID: 8557118) Palmer RH … Parker PJ (FEBS letters 1996) 3 4 22 58
  2. Relationship between the major protein kinase C substrates acidic 80-kDa protein-kinase-C substrate (80K) and myristoylated alanine-rich C-kinase substrate (MARCKS). Members of a gene family or equivalent genes in different species. (PMID: 1396720) Herget T … Rozengurt E (European journal of biochemistry 1992) 3 4 22 58
  3. Molecular cloning and chromosomal mapping of a cDNA encoding human 80K-L protein: major substrate for protein kinase C. (PMID: 1427823) Sakai K … Shimizu N (Genomics 1992) 3 4 22 58
  4. The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization. (PMID: 1860846) Harlan DM … Blackshear PJ (The Journal of biological chemistry 1991) 3 4 22 58
  5. Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway. (PMID: 20047593) Techasen A … Yongvanit P (Cancer science 2010) 3 22 58

Products for MARCKS Gene

Sources for MARCKS Gene

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