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Aliases for MIR7-1 Gene

Subcategory (RNA class) for MIR7-1 Gene

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Quality Score for this RNA gene is

18.2

Aliases for MIR7-1 Gene

  • MicroRNA 7-1 2 3 5
  • Hsa-Mir-7-1 3
  • MiR-7-5p 3
  • Mir-7-1 3
  • MIRN7-1 3

External Ids for MIR7-1 Gene

Previous HGNC Symbols for MIR7-1 Gene

  • MIRN7-1

Previous GeneCards Identifiers for MIR7-1 Gene

  • GC09M085776
  • GC09M086584

Summaries for MIR7-1 Gene

Entrez Gene Summary for MIR7-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-1 Gene

MIR7-1 (MicroRNA 7-1) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR7-1 include Pituitary Adenoma. Among its related pathways are MicroRNAs in cancer and SUMOylation.

fRNAdb sequence ontologies for MIR7-1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR7-1

Additional gene information for MIR7-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR7-1 Gene

Genomics for MIR7-1 Gene

GeneHancer (GH) Regulatory Elements for MIR7-1 Gene

Promoters and enhancers for MIR7-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J083965 Enhancer 1 Ensembl ENCODE 0.7 +4.3 4269 1.2 HDAC1 PKNOX1 RB1 STAT5A ZNF48 POLR2B E2F8 ATF7 PAF1 SMAD5 KIF27 LOC105376116 IDNK ENSG00000231616 MIR7-1 C9orf64
GH09J083961 Enhancer 0.8 ENCODE 0.4 +7.4 7374 1.3 INSM2 FEZF1 YY1 KLF7 ZNF362 RXRA CEBPB ELF1 ZEB2 ZNF518A KIF27 LOC105376116 RMI1 C9orf64 MIR7-1
GH09J083959 Enhancer 0.6 ENCODE 0.4 +10.6 10626 0.2 ZNF384 TEAD3 MAFF JUND ZNF629 PRDM10 WT1 ZXDB C9orf64 MIR7-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR7-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR7-1 Gene

Genomic Locations for MIR7-1 Gene
chr9:83,969,748-83,969,857
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr9:86,584,663-86,584,772
(GRCh37/hg19)
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR7-1 Gene

Genes around MIR7-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR7-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-1 Gene

ORGUL Member Location for MIR7-1 Gene

ORGUL Member Location for MIR7-1 gene

Proteins for MIR7-1 Gene

Post-translational modifications for MIR7-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-1 Gene

Domains & Families for MIR7-1 Gene

Gene Families for MIR7-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR7-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR7-1 Gene

Function for MIR7-1 Gene

Gene Ontology (GO) - Molecular Function for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 27431648
genes like me logo Genes that share ontologies with MIR7-1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-1 Gene

Localization for MIR7-1 Gene

Gene Ontology (GO) - Cellular Components for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 18766170
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR7-1 Gene

Pathways & Interactions for MIR7-1 Gene

genes like me logo Genes that share pathways with MIR7-1: view

Pathways by source for MIR7-1 Gene

1 KEGG pathway for MIR7-1 Gene

Interacting Proteins for MIR7-1 Gene

Gene Ontology (GO) - Biological Process for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 27431648
GO:1903671 negative regulation of sprouting angiogenesis IMP 27431648
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for SIGNOR curated interactions for MIR7-1 Gene

Drugs & Compounds for MIR7-1 Gene

No Compound Related Data Available

Transcripts for MIR7-1 Gene

fRNAdb Secondary structures for MIR7-1 Gene

  • FR244379

mRNA/cDNA for MIR7-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-1 Gene

No ASD Table

Relevant External Links for MIR7-1 Gene

GeneLoc Exon Structure for
MIR7-1
ECgene alternative splicing isoforms for
MIR7-1

Expression for MIR7-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR7-1 Gene

genes like me logo Genes that share expression patterns with MIR7-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7-1 Gene

Orthologs for MIR7-1 Gene

Evolution for MIR7-1 Gene

ENSEMBL:
Gene Tree for MIR7-1 (if available)
TreeFam:
Gene Tree for MIR7-1 (if available)

No data available for Orthologs for MIR7-1 Gene

Paralogs for MIR7-1 Gene

No data available for Paralogs for MIR7-1 Gene

Variants for MIR7-1 Gene

Sequence variations from dbSNP and Humsavar for MIR7-1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs767454980 pathogenic, not provided 83,970,273(-) G/A/T upstream_transcript_variant
rs1002519950 -- 83,969,629(-) C/T downstream_transcript_variant
rs1003514753 -- 83,969,638(-) G/A downstream_transcript_variant
rs1006188137 -- 83,970,973(-) T/A upstream_transcript_variant
rs1006460187 -- 83,971,517(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR7-1 Gene

Variant ID Type Subtype PubMed ID
esv2759701 CNV gain 17122850
esv3620911 CNV gain 21293372
nsv1043703 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv469859 CNV gain 16826518
nsv831644 CNV gain 17160897
nsv8541 CNV gain 18304495
nsv972408 CNV duplication 23825009

Additional Variant Information for MIR7-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR7-1 Gene

Disorders for MIR7-1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR7-1 Gene - From: miR2Disease

Disorder Aliases PubMed IDs
pituitary adenoma
  • adenoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR7-1

genes like me logo Genes that share disorders with MIR7-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR7-1 Gene

Publications for MIR7-1 Gene

  1. MiR-7-5p functions as a tumor suppressor by targeting SOX18 in pancreatic ductal adenocarcinoma. (PMID: 29408481) Zhu W … Leng X (Biochemical and biophysical research communications 2018) 3 58
  2. Breviscapine suppresses the growth of non-small cell lung cancer by enhancing microRNA-7 expression. (PMID: 28229971) Zeng J … Cai S (Journal of biosciences 2017) 3 58
  3. Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma. (PMID: 28459371) Tarek M … Montasser IF (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in vitro. (PMID: 28986256) Jiang MJ … Tian L (Biochemical and biophysical research communications 2017) 3 58
  5. Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control. (PMID: 28945992) Nunez Lopez YO … Seyhan AA (The Journal of nutritional biochemistry 2017) 3 58

Products for MIR7-1 Gene

Sources for MIR7-1 Gene

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