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Aliases for TACSTD2 Gene

Aliases for TACSTD2 Gene

  • Tumor Associated Calcium Signal Transducer 2 2 3 5
  • Pancreatic Carcinoma Marker Protein GA733-1 3 4
  • Cell Surface Glycoprotein Trop-2 3 4
  • GA733-1 3 4
  • TROP2 3 4
  • M1S1 3 4
  • 40kD Glycoprotein, Identified By Monoclonal Antibody GA733 3
  • Membrane Component, Chromosome 1, Surface Marker 1 3
  • Gastrointestinal Tumor-Associated Antigen GA7331 3
  • Membrane Component Chromosome 1 Surface Marker 1 4
  • Tumor-Associated Calcium Signal Transducer 2 3
  • Pancreatic Carcinoma Marker Protein GA7331 3
  • Cell Surface Glycoprotein TROP2 3
  • Epithelial Glycoprotein-1 3
  • Truncated TACSTD2 3
  • GA7331 3
  • EGP-1 3
  • EGP1 3
  • GP50 3

External Ids for TACSTD2 Gene

Previous HGNC Symbols for TACSTD2 Gene

  • M1S1

Previous GeneCards Identifiers for TACSTD2 Gene

  • GC01M058957
  • GC01M057955
  • GC01M058398
  • GC01M058411
  • GC01M058412
  • GC01M058752
  • GC01M058813
  • GC01M059041
  • GC01M057151

Summaries for TACSTD2 Gene

Entrez Gene Summary for TACSTD2 Gene

  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

GeneCards Summary for TACSTD2 Gene

TACSTD2 (Tumor Associated Calcium Signal Transducer 2) is a Protein Coding gene. Diseases associated with TACSTD2 include Corneal Dystrophy, Gelatinous Drop-Like and Lattice Corneal Dystrophy. Among its related pathways are Ca, cAMP and Lipid Signaling and Adhesion. An important paralog of this gene is EPCAM.

UniProtKB/Swiss-Prot for TACSTD2 Gene

  • May function as a growth factor receptor.

Gene Wiki entry for TACSTD2 Gene

Additional gene information for TACSTD2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACSTD2 Gene

Genomics for TACSTD2 Gene

GeneHancer (GH) Regulatory Elements for TACSTD2 Gene

Promoters and enhancers for TACSTD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J058578 Enhancer 0.5 dbSUPER 695.1 -1.7 -1739 1 BCOR ZNF362 CREB1 ZMYM3 ZNF384 TACSTD2 OMA1 DAB1 GC01M058574
GH01J058572 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 44.9 +2.2 2224 6.5 PKNOX1 SMAD1 SIN3A IRF4 ZNF207 ATF7 FOS RUNX3 JUNB NBN TACSTD2 OMA1 DAB1 RN7SL713P GC01M058574
GH01J058583 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 44.7 -7.4 -7440 3.8 PKNOX1 BATF RFX5 SMARCC2 RCOR1 ATF7 ETV6 FOS IKZF2 RUNX3 TACSTD2 OMA1 DAB1 GC01M058574
GH01J058544 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 30.7 +31.6 31610 2.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 POLR2B OMA1 DAB1 TACSTD2 GC01M058497
GH01J058591 Enhancer 1.1 Ensembl ENCODE dbSUPER 22 -15.0 -14993 2.1 NCOA3 NFIB JUN MAX HIC1 POLR2A ZBTB48 RCOR1 CHD2 RXRA TACSTD2 GC01M058574 AK2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TACSTD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TACSTD2 gene promoter:
  • XBP-1
  • AML1a
  • HEN1
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • AhR
  • FOXD3

Genomic Locations for TACSTD2 Gene

Genomic Locations for TACSTD2 Gene
2,351 bases
Minus strand
2,072 bases
Minus strand

Genomic View for TACSTD2 Gene

Genes around TACSTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACSTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACSTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACSTD2 Gene

Proteins for TACSTD2 Gene

  • Protein details for TACSTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor-associated calcium signal transducer 2
    Protein Accession:
    Secondary Accessions:
    • Q15658
    • Q6FG48
    • Q7Z7Q4
    • Q96QD2

    Protein attributes for TACSTD2 Gene

    323 amino acids
    Molecular mass:
    35709 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TACSTD2 Gene

neXtProt entry for TACSTD2 Gene

Post-translational modifications for TACSTD2 Gene

  • The N-terminus is blocked.
  • Glycosylation at isoforms=208, posLast=168168, posLast=120120, posLast=9393, and isoforms=33
  • Modification sites at PhosphoSitePlus

Other Protein References for TACSTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TACSTD2 Gene

Domains & Families for TACSTD2 Gene

Gene Families for TACSTD2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for TACSTD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EPCAM family.
  • Belongs to the EPCAM family.
genes like me logo Genes that share domains with TACSTD2: view

Function for TACSTD2 Gene

Molecular function for TACSTD2 Gene

UniProtKB/Swiss-Prot Function:
May function as a growth factor receptor.

Phenotypes From GWAS Catalog for TACSTD2 Gene

Gene Ontology (GO) - Molecular Function for TACSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15607035
GO:0038023 signaling receptor activity TAS 7665234
GO:0098641 cadherin binding involved in cell-cell adhesion IBA --
genes like me logo Genes that share ontologies with TACSTD2: view
genes like me logo Genes that share phenotypes with TACSTD2: view

Human Phenotype Ontology for TACSTD2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TACSTD2 Gene

MGI Knock Outs for TACSTD2:

Animal Model Products

miRNA for TACSTD2 Gene

miRTarBase miRNAs that target TACSTD2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TACSTD2 Gene

Localization for TACSTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACSTD2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACSTD2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TACSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IBA --
GO:0005634 nucleus IBA,IEA --
GO:0005829 cytosol TAS 10192395
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 7665234
genes like me logo Genes that share ontologies with TACSTD2: view

Pathways & Interactions for TACSTD2 Gene

genes like me logo Genes that share pathways with TACSTD2: view

Pathways by source for TACSTD2 Gene

2 Cell Signaling Technology pathways for TACSTD2 Gene

Gene Ontology (GO) - Biological Process for TACSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 7665234
GO:0007601 visual perception IEA,TAS --
GO:0008283 cell proliferation TAS 7665234
GO:0010633 negative regulation of epithelial cell migration IEA,ISS --
GO:0050678 regulation of epithelial cell proliferation IEA --
genes like me logo Genes that share ontologies with TACSTD2: view

No data available for SIGNOR curated interactions for TACSTD2 Gene

Drugs & Compounds for TACSTD2 Gene

(3) Drugs for TACSTD2 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IMMU-132 Pharma inhibitor TROP2-targeted TOPO I inhibitor 0

(1) Additional Compounds for TACSTD2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TACSTD2: view

Transcripts for TACSTD2 Gene

mRNA/cDNA for TACSTD2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(302) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACSTD2 Gene

Tumor-associated calcium signal transducer 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACSTD2 Gene

No ASD Table

Relevant External Links for TACSTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TACSTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TACSTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACSTD2 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.5), Minor Salivary Gland (x9.4), Skin - Not Sun Exposed (Suprapubic) (x5.5), Skin - Sun Exposed (Lower leg) (x5.5), and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for TACSTD2 Gene

This gene is overexpressed in Nasal epithelium (53.3) and Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TACSTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TACSTD2 Gene:


SOURCE GeneReport for Unigene cluster for TACSTD2 Gene:


mRNA Expression by UniProt/SwissProt for TACSTD2 Gene:

Tissue specificity: Placenta, pancreatic carcinoma cell lines.

Evidence on tissue expression from TISSUES for TACSTD2 Gene

  • Pancreas(4.4)
  • Kidney(3)
  • Lung(2.9)
  • Skin(2.6)
  • Intestine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TACSTD2 Gene

Germ Layers:
  • ectoderm
  • nervous
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TACSTD2: view

No data available for Protein tissue co-expression partners for TACSTD2 Gene

Orthologs for TACSTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TACSTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TACSTD2 34 33
  • 99.78 (n)
(Canis familiaris)
Mammalia TACSTD2 33
  • 88.13 (n)
(Bos Taurus)
Mammalia TACSTD2 34 33
  • 86.31 (n)
(Rattus norvegicus)
Mammalia Tacstd2 33
  • 82.22 (n)
(Mus musculus)
Mammalia Tacstd2 16 34 33
  • 81.94 (n)
(Monodelphis domestica)
Mammalia TACSTD2 34
  • 65 (a)
(Gallus gallus)
Aves TACSTD2 34 33
  • 52.41 (n)
(Anolis carolinensis)
Reptilia TACSTD2 34
  • 52 (a)
(Danio rerio)
Actinopterygii epcam 34
  • 35 (a)
Species where no ortholog for TACSTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACSTD2 Gene

Gene Tree for TACSTD2 (if available)
Gene Tree for TACSTD2 (if available)
Evolutionary constrained regions (ECRs) for TACSTD2: view image

Paralogs for TACSTD2 Gene

Paralogs for TACSTD2 Gene

(1) SIMAP similar genes for TACSTD2 Gene using alignment to 3 proteins:

  • C5IX07_HUMAN
  • D1MF27_HUMAN
genes like me logo Genes that share paralogs with TACSTD2: view

Variants for TACSTD2 Gene

Sequence variations from dbSNP and Humsavar for TACSTD2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1062964 likely-benign, Corneal Dystrophy, Dominant/Recessive 58,576,716(-) C/G coding_sequence_variant, missense_variant
rs114373153 likely-benign, Corneal Dystrophy, Dominant/Recessive 58,576,268(-) T/C coding_sequence_variant, missense_variant
rs12121124 likely-benign, Corneal Dystrophy, Dominant/Recessive 58,576,329(-) G/A coding_sequence_variant, synonymous_variant
rs14008 likely-benign, Corneal Dystrophy, Dominant/Recessive 58,576,509(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs144787622 uncertain-significance, Corneal Dystrophy, Dominant/Recessive 58,576,395(-) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TACSTD2 Gene

Variant ID Type Subtype PubMed ID
dgv40e212 CNV loss 25503493
nsv1003930 CNV gain 25217958

Variation tolerance for TACSTD2 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACSTD2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACSTD2 Gene

Disorders for TACSTD2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for TACSTD2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, gelatinous drop-like
  • gdld
lattice corneal dystrophy
  • familial amyloid neuropathy, finnish type
corneal dystrophy
epithelial and subepithelial dystrophy
  • beef tapeworm infection
- elite association - COSMIC cancer census association via MalaCards


  • Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. {ECO:0000269 PubMed:10192395}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TACSTD2

genes like me logo Genes that share disorders with TACSTD2: view

No data available for Genatlas for TACSTD2 Gene

Publications for TACSTD2 Gene

  1. Retroposition in a family of carcinoma-associated antigen genes. (PMID: 8382772) Linnenbach AJ … Huebner K (Molecular and cellular biology 1993) 2 3 4 22 58
  2. Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. (PMID: 15013888) Tian X … Liu Z (American journal of ophthalmology 2004) 3 22 44 58
  3. A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. (PMID: 11687514) Tasa G … Lang A (Investigative ophthalmology & visual science 2001) 3 4 22 58
  4. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. (PMID: 7665234) Fornaro M … Alberti S (International journal of cancer 1995) 3 4 22 58
  5. Identification and characterization of a novel TACSTD2 mutation in gelatinous drop-like corneal dystrophy. (PMID: 20454699) Paliwal P … Vajpayee RB (Molecular vision 2010) 3 22 58

Products for TACSTD2 Gene

Sources for TACSTD2 Gene

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