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Aliases for TMEM215 Gene

Aliases for TMEM215 Gene

  • Transmembrane Protein 215 2 3 3 5

External Ids for TMEM215 Gene

Previous GeneCards Identifiers for TMEM215 Gene

  • GC09P032775
  • GC09P032741

Summaries for TMEM215 Gene

GeneCards Summary for TMEM215 Gene

TMEM215 (Transmembrane Protein 215) is a Protein Coding gene.

Additional gene information for TMEM215 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM215 Gene

Genomics for TMEM215 Gene

GeneHancer (GH) Regulatory Elements for TMEM215 Gene

Promoters and enhancers for TMEM215 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J032783 Promoter/Enhancer 1 EPDnew ENCODE 650.7 +0.0 39 0.2 CTCF NFIL3 POLR2A HLF SIN3A EZH2 TMEM215 LOC105376017 GC09P032777 ENSG00000272113
GH09J032784 Enhancer 0.4 ENCODE 650.7 -0.3 -261 0.2 SIN3A EZH2 TMEM215 LOC105376017 GC09P032777
GH09J032422 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.8 -358.1 -358084 6.5 FOXA2 ARID4B ZNF48 YY1 FOS RXRA NFYC REST PPARG KAT8 ACO1 NDUFB6 TMEM215 DDX58 LOC105376014
GH09J032429 Enhancer 0.9 Ensembl ENCODE dbSUPER 8.9 -352.2 -352220 3.9 CTCF JUND TFAP4 JUN BACH1 SMC3 RAD21 ACO1 DDX58 TMEM215 LOC105376014
GH09J032672 Enhancer 0.7 ENCODE 10.4 -110.9 -110861 1 JUN RAD21 BRCA1 CTBP1 GATA3 RCOR1 FOSL2 FOS CHD2 CEBPB TMEM215 SNRPCP1 PIR39260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM215 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM215 gene promoter:
  • Arnt
  • Max1
  • c-Myc
  • E2F-1
  • E2F
  • Olf-1
  • AML1a
  • GATA-1
  • C/EBPbeta

Genomic Locations for TMEM215 Gene

Genomic Locations for TMEM215 Gene
chr9:32,783,499-32,789,201
(GRCh38/hg38)
Size:
5,703 bases
Orientation:
Plus strand
chr9:32,783,497-32,789,199
(GRCh37/hg19)
Size:
5,703 bases
Orientation:
Plus strand

Genomic View for TMEM215 Gene

Genes around TMEM215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM215 Gene

Proteins for TMEM215 Gene

  • Protein details for TMEM215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68D42-TM215_HUMAN
    Recommended name:
    Transmembrane protein 215
    Protein Accession:
    Q68D42
    Secondary Accessions:
    • Q6ZUU2

    Protein attributes for TMEM215 Gene

    Size:
    235 amino acids
    Molecular mass:
    25806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM215 Gene

Post-translational modifications for TMEM215 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM215 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM215 Gene

Domains & Families for TMEM215 Gene

Gene Families for TMEM215 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM215 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM215 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM215: view

No data available for UniProtKB/Swiss-Prot for TMEM215 Gene

Function for TMEM215 Gene

Phenotypes From GWAS Catalog for TMEM215 Gene

genes like me logo Genes that share phenotypes with TMEM215: view

Animal Model Products

miRNA for TMEM215 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM215 Gene

Localization for TMEM215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM215 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM215 gene
Compartment Confidence
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Endoplasmic reticulum (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM215: view

Pathways & Interactions for TMEM215 Gene

SuperPathways for TMEM215 Gene

No Data Available

Interacting Proteins for TMEM215 Gene

Gene Ontology (GO) - Biological Process for TMEM215 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM215 Gene

Drugs & Compounds for TMEM215 Gene

No Compound Related Data Available

Transcripts for TMEM215 Gene

mRNA/cDNA for TMEM215 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM215 Gene

Transmembrane protein 215:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM215 Gene

No ASD Table

Relevant External Links for TMEM215 Gene

GeneLoc Exon Structure for
TMEM215
ECgene alternative splicing isoforms for
TMEM215

Expression for TMEM215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM215 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM215 Gene

This gene is overexpressed in Testis (x17.8) and Nerve - Tibial (x17.8).

Protein differential expression in normal tissues from HIPED for TMEM215 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM215 Gene



Protein tissue co-expression partners for TMEM215 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM215 Gene:

TMEM215

SOURCE GeneReport for Unigene cluster for TMEM215 Gene:

Hs.522063

Evidence on tissue expression from TISSUES for TMEM215 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with TMEM215: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM215 Gene

Orthologs for TMEM215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM215 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM215 34 33
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM215 34 33
  • 90.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM215 34 33
  • 90.21 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem215 16 34 33
  • 87.94 (n)
rat
(Rattus norvegicus)
Mammalia LOC690918 33
  • 86.81 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM215 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM215 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM215 34 33
  • 70.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM215 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem215 33
  • 60.72 (n)
Species where no ortholog for TMEM215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM215 Gene

ENSEMBL:
Gene Tree for TMEM215 (if available)
TreeFam:
Gene Tree for TMEM215 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM215: view image

Paralogs for TMEM215 Gene

No data available for Paralogs for TMEM215 Gene

Variants for TMEM215 Gene

Sequence variations from dbSNP and Humsavar for TMEM215 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000021478 -- 32,788,060(+) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000055809 -- 32,785,909(+) A/G 3_prime_UTR_variant, intron_variant
rs1000403763 -- 32,786,324(+) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1002389762 -- 32,786,080(+) A/T 3_prime_UTR_variant, intron_variant
rs1003347998 -- 32,789,293(+) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM215 Gene

Variant ID Type Subtype PubMed ID
esv3620303 CNV gain 21293372
nsv614143 CNV gain 21841781

Variation tolerance for TMEM215 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM215 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM215

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM215 Gene

Disorders for TMEM215 Gene

Additional Disease Information for TMEM215

No disorders were found for TMEM215 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM215 Gene

Publications for TMEM215 Gene

  1. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. (PMID: 22658931) Pajewski NM … Kaslow RA (Vaccine 2012) 3 58
  2. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X … Sun J (Human molecular genetics 2012) 44 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for TMEM215 Gene

Sources for TMEM215 Gene

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