Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MEX3D Gene

Aliases for MEX3D Gene

  • Mex-3 RNA Binding Family Member D 2 3 5
  • RING Finger And KH Domain-Containing Protein 1 3 4
  • Ring Finger And KH Domain Containing 1 2 3
  • Bcl-2 ARE RNA Binding Protein 2 3
  • RING Finger Protein 193 3 4
  • RNF193 3 4
  • RKHD1 3 4
  • TINO 3 4
  • Ring Finger (C3HC4 Type) And KH Domain Containing 1 3
  • Mex-3 Homolog D (C. Elegans) 2
  • RNA-Binding Protein MEX3D 3
  • OK/SW-Cl.4 3
  • KIAA2031 4
  • MEX-3D 3
  • MEX3 3

External Ids for MEX3D Gene

Previous HGNC Symbols for MEX3D Gene

  • RKHD1

Previous GeneCards Identifiers for MEX3D Gene

  • GC19M001508
  • GC19M001328

Summaries for MEX3D Gene

GeneCards Summary for MEX3D Gene

MEX3D (Mex-3 RNA Binding Family Member D) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot for MEX3D Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3D Gene

Additional gene information for MEX3D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3D Gene

Genomics for MEX3D Gene

GeneHancer (GH) Regulatory Elements for MEX3D Gene

Promoters and enhancers for MEX3D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J001565 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +1.0 956 3 ARNT ARID4B SIN3A ZNF48 GLIS2 E2F8 SP3 MXD4 REST PPARG MEX3D GC19P001563 GC19M001562
GH19J001202 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 29.1 +361.3 361301 8 ZFP64 FEZF1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A STK11 CIRBP TMEM259 DAZAP1 LOC100288123 TCF3 PTBP1 GRIN3B DOT1L POLRMT
GH19J001382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 29.8 +184.0 184032 2.2 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NDUFS7 TRF-GAA1-6 TRN-GTT2-6 PIR60227 PIR43938 SF3A2 CIRBP TMEM259 DAZAP1 LOC100288123
GH19J001037 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.9 +527.6 527623 6 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN ABCA7 ENSG00000279753 DAZAP1 CIRBP LOC100288123 TMEM259 TCF3 PTBP1 GRIN3B ENSG00000267317
GH19J001164 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.2 +398.4 398402 10.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 SBNO2 LOC102725180 LOC100288123 TMEM259 DAZAP1 TCF3 PTBP1 MED16 CIRBP MIER2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEX3D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEX3D gene promoter:
  • RP58
  • Egr-4
  • MyoD
  • En-1
  • p53
  • ATF6
  • AP-1
  • c-Fos
  • c-Jun
  • NRSF form 2

Genomic Locations for MEX3D Gene

Genomic Locations for MEX3D Gene
chr19:1,554,669-1,568,058
(GRCh38/hg38)
Size:
13,390 bases
Orientation:
Minus strand
chr19:1,554,668-1,568,057
(GRCh37/hg19)
Size:
13,390 bases
Orientation:
Minus strand

Genomic View for MEX3D Gene

Genes around MEX3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3D Gene

Proteins for MEX3D Gene

  • Protein details for MEX3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XN8-MEX3D_HUMAN
    Recommended name:
    RNA-binding protein MEX3D
    Protein Accession:
    Q86XN8
    Secondary Accessions:
    • A0PJL8
    • A1L023
    • E9PAL6
    • Q71M49

    Protein attributes for MEX3D Gene

    Size:
    651 amino acids
    Molecular mass:
    64883 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ04763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEX3D Gene

    Alternative splice isoforms for MEX3D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEX3D Gene

Post-translational modifications for MEX3D Gene

Other Protein References for MEX3D Gene

No data available for DME Specific Peptides for MEX3D Gene

Domains & Families for MEX3D Gene

Gene Families for MEX3D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEX3D Gene

Graphical View of Domain Structure for InterPro Entry

Q86XN8

UniProtKB/Swiss-Prot:

MEX3D_HUMAN :
  • Binds RNA through its KH domains.
Domain:
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3D: view

Function for MEX3D Gene

Molecular function for MEX3D Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Phenotypes From GWAS Catalog for MEX3D Gene

Gene Ontology (GO) - Molecular Function for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003727 single-stranded RNA binding IBA --
GO:0017091 AU-rich element binding IDA 14769789
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3D: view
genes like me logo Genes that share phenotypes with MEX3D: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEX3D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3D Gene

Localization for MEX3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3D Gene

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3D gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14769789
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
GO:0048471 perinuclear region of cytoplasm IDA 14769789
genes like me logo Genes that share ontologies with MEX3D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MEX3D Gene

Pathways & Interactions for MEX3D Gene

SuperPathways for MEX3D Gene

No Data Available

Interacting Proteins for MEX3D Gene

Gene Ontology (GO) - Biological Process for MEX3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression NAS 14769789
GO:0017148 negative regulation of translation IBA --
GO:0061157 mRNA destabilization NAS 14769789
genes like me logo Genes that share ontologies with MEX3D: view

No data available for Pathways by source and SIGNOR curated interactions for MEX3D Gene

Drugs & Compounds for MEX3D Gene

No Compound Related Data Available

Transcripts for MEX3D Gene

mRNA/cDNA for MEX3D Gene

Unigene Clusters for MEX3D Gene

Mex-3 homolog D (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEX3D

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3D Gene

No ASD Table

Relevant External Links for MEX3D Gene

GeneLoc Exon Structure for
MEX3D
ECgene alternative splicing isoforms for
MEX3D

Expression for MEX3D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEX3D Gene

mRNA differential expression in normal tissues according to GTEx for MEX3D Gene

This gene is overexpressed in Testis (x9.7).

Protein differential expression in normal tissues from HIPED for MEX3D Gene

This gene is overexpressed in Fetal Brain (30.8), Testis (18.8), Placenta (11.6), and Fetal ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3D Gene



Protein tissue co-expression partners for MEX3D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEX3D Gene:

MEX3D

SOURCE GeneReport for Unigene cluster for MEX3D Gene:

Hs.436495

mRNA Expression by UniProt/SwissProt for MEX3D Gene:

Q86XN8-MEX3D_HUMAN
Tissue specificity: Ubiquitously expressed in all the cell lines and tissues tested.

Evidence on tissue expression from TISSUES for MEX3D Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MEX3D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3D Gene

Orthologs for MEX3D Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3D 34 33
  • 98.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MEX3D 34 33
  • 85.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTSL5 33
  • 82.32 (n)
mouse
(Mus musculus)
Mammalia Mex3d 16 34 33
  • 80.25 (n)
rat
(Rattus norvegicus)
Mammalia Mex3d 33
  • 80.25 (n)
oppossum
(Monodelphis domestica)
Mammalia MEX3D 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEX3D 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEX3D 34 33
  • 74.94 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3d 33
  • 60.28 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100534722 33
  • 61.88 (n)
MEX3D 34
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 34
  • 33 (a)
OneToMany
Species where no ortholog for MEX3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3D Gene

ENSEMBL:
Gene Tree for MEX3D (if available)
TreeFam:
Gene Tree for MEX3D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEX3D: view image

Paralogs for MEX3D Gene

Paralogs for MEX3D Gene

(4) SIMAP similar genes for MEX3D Gene using alignment to 2 proteins:

  • MEX3D_HUMAN
  • S4R446_HUMAN
genes like me logo Genes that share paralogs with MEX3D: view

Variants for MEX3D Gene

Sequence variations from dbSNP and Humsavar for MEX3D Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000089885 -- 1,555,863(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs1000113099 -- 1,559,032(-) G/C intron_variant
rs1000269120 -- 1,563,730(-) CCCCC/CCCC genic_upstream_transcript_variant, intron_variant
rs1000318030 -- 1,562,875(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000437577 -- 1,567,407(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3D Gene

Variant ID Type Subtype PubMed ID
dgv6202n54 CNV gain+loss 21841781
dgv6203n54 CNV gain 21841781
dgv6204n54 CNV gain 21841781
esv23826 CNV loss 19812545
esv32942 CNV gain+loss 17666407
nsv1072837 CNV deletion 25765185
nsv1121962 CNV deletion 24896259
nsv1133435 CNV deletion 24896259
nsv1144853 CNV deletion 24896259
nsv517758 CNV loss 19592680
nsv578298 CNV loss 21841781
nsv578299 CNV gain 21841781
nsv578300 CNV loss 21841781
nsv578306 CNV loss 21841781
nsv578311 CNV gain 21841781
nsv578312 CNV loss 21841781
nsv953942 CNV deletion 24416366

Variation tolerance for MEX3D Gene

Gene Damage Index Score: 2.08; 38.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEX3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3D

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3D Gene

Disorders for MEX3D Gene

Additional Disease Information for MEX3D

No disorders were found for MEX3D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3D Gene

Publications for MEX3D Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein. (PMID: 14769789) Donnini M … Schiavone N (The Journal of biological chemistry 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for MEX3D Gene

Sources for MEX3D Gene

Content
Loading form....