Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPRED3 Gene

Aliases for SPRED3 Gene

  • Sprouty Related EVH1 Domain Containing 3 2 3 5
  • Spred-3 3 4
  • Eve-3 3 4
  • Sprouty-Related, EVH1 Domain-Containing Protein 3 3

External Ids for SPRED3 Gene

Previous GeneCards Identifiers for SPRED3 Gene

  • GC19U900378
  • GC19P043574
  • GC19P038880
  • GC19P035328

Summaries for SPRED3 Gene

Entrez Gene Summary for SPRED3 Gene

  • This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SPRED3 Gene

SPRED3 (Sprouty Related EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include Legius Syndrome. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. An important paralog of this gene is SPRED2.

UniProtKB/Swiss-Prot for SPRED3 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Gene Wiki entry for SPRED3 Gene

Additional gene information for SPRED3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED3 Gene

Genomics for SPRED3 Gene

GeneHancer (GH) Regulatory Elements for SPRED3 Gene

Promoters and enhancers for SPRED3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I038386 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 339 4 HDGF ATF1 SIN3A ZNF2 TCF12 ZNF121 GLIS2 ZNF213 ZNF143 KLF7 GGN SPRED3 ZFP30 ZNF607 ZNF793 CATSPERG C19orf33 ZNF570 ZNF573 HNRNPL
GH19I038387 Enhancer 0.5 ENCODE 550.8 -1.9 -1925 0.2 ZNF202 ZBTB6 ZBTB33 EZH2 ENSG00000267090 SPRED3 ZNF573 HNRNPL RASGRP4 RYR1 ZNF571 PAK4 GGN GC19P038373
GH19I038361 Promoter/Enhancer 1.5 Ensembl ENCODE 11 -26.1 -26069 1.6 PKNOX1 ATF1 ZNF133 SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ELK1 KLF7 ENSG00000266963 C19orf33 CATSPERG GGN SPRED3 FAM98C DPF1 PSMD8 GC19M038854
GH19I038269 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.4 -117.7 -117717 1.7 ARNT SIN3A FEZF1 ZNF2 ZNF213 REST ZNF592 SMARCA4 ZSCAN16 GLIS1 C19orf33 CATSPERG HNRNPL HKR1 ZNF607 ZNF793 LOC100631378 KCNK6 DPF1 YIF1B
GH19I039125 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.7 +738.9 738932 4.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 SP3 NFYC PAK4 PIR35823 HNRNPL FBL ZNF780B ZNF780A ENSG00000269688 ENSG00000269172 EID2B RN7SL566P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPRED3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPRED3 gene promoter:

Genomic Locations for SPRED3 Gene

Genomic Locations for SPRED3 Gene
chr19:38,388,421-38,399,884
(GRCh38/hg38)
Size:
11,464 bases
Orientation:
Plus strand
chr19:38,879,061-38,886,881
(GRCh37/hg19)

Genomic View for SPRED3 Gene

Genes around SPRED3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRED3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRED3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED3 Gene

Proteins for SPRED3 Gene

  • Protein details for SPRED3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2MJR0-SPRE3_HUMAN
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Protein Accession:
    Q2MJR0
    Secondary Accessions:
    • Q2MJR1

    Protein attributes for SPRED3 Gene

    Size:
    410 amino acids
    Molecular mass:
    42670 Da
    Quaternary structure:
    • Interacts with Ras.

    Alternative splice isoforms for SPRED3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPRED3 Gene

Post-translational modifications for SPRED3 Gene

Other Protein References for SPRED3 Gene

No data available for DME Specific Peptides for SPRED3 Gene

Domains & Families for SPRED3 Gene

Gene Families for SPRED3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SPRED3 Gene

Suggested Antigen Peptide Sequences for SPRED3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRED3: view

No data available for UniProtKB/Swiss-Prot for SPRED3 Gene

Function for SPRED3 Gene

Molecular function for SPRED3 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Phenotypes From GWAS Catalog for SPRED3 Gene

genes like me logo Genes that share phenotypes with SPRED3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRED3 Gene

Localization for SPRED3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRED3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPRED3: view

Pathways & Interactions for SPRED3 Gene

SuperPathways for SPRED3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by PTK6
genes like me logo Genes that share pathways with SPRED3: view

Pathways by source for SPRED3 Gene

Gene Ontology (GO) - Biological Process for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SPRED3: view

No data available for SIGNOR curated interactions for SPRED3 Gene

Drugs & Compounds for SPRED3 Gene

No Compound Related Data Available

Transcripts for SPRED3 Gene

mRNA/cDNA for SPRED3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRED3 Gene

Sprouty-related, EVH1 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED3 Gene

No ASD Table

Relevant External Links for SPRED3 Gene

GeneLoc Exon Structure for
SPRED3
ECgene alternative splicing isoforms for
SPRED3

Expression for SPRED3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRED3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRED3 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRED3 Gene



Protein tissue co-expression partners for SPRED3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRED3 Gene:

SPRED3

SOURCE GeneReport for Unigene cluster for SPRED3 Gene:

Hs.196011

mRNA Expression by UniProt/SwissProt for SPRED3 Gene:

Q2MJR0-SPRE3_HUMAN
Tissue specificity: Expression is restricted to liver.

Evidence on tissue expression from TISSUES for SPRED3 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with SPRED3: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRED3 Gene

Orthologs for SPRED3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRED3 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia SPRED3 33 34
  • 92.6 (n)
cow
(Bos Taurus)
Mammalia SPRED3 33 34
  • 91.33 (n)
mouse
(Mus musculus)
Mammalia Spred3 33 16 34
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Spred3 33
  • 83.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SPRED3 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spred 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 34
  • 22 (a)
OneToMany
Species where no ortholog for SPRED3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRED3 Gene

ENSEMBL:
Gene Tree for SPRED3 (if available)
TreeFam:
Gene Tree for SPRED3 (if available)

Paralogs for SPRED3 Gene

Paralogs for SPRED3 Gene

(3) SIMAP similar genes for SPRED3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRED3: view

Variants for SPRED3 Gene

Sequence variations from dbSNP and Humsavar for SPRED3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000495198 -- 38,388,820(+) G/T upstream_transcript_variant
rs1000674996 -- 38,388,072(+) C/A upstream_transcript_variant
rs1001012869 -- 38,394,889(+) A/T intron_variant
rs1001576983 -- 38,390,190(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002456043 -- 38,396,454(+) A/G 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED3 Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for SPRED3 Gene

Gene Damage Index Score: 2.68; 46.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRED3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRED3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED3 Gene

Disorders for SPRED3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPRED3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • neurofibromatosis type 1-like syndrome; nfls
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPRED3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPRED3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED3 Gene

Publications for SPRED3 Gene

  1. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. (PMID: 16478641) King JA … Hovens CM (Journal of hepatology 2006) 3 4 58
  2. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y … Katoh M (International journal of molecular medicine 2006) 3 22 58
  3. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. (PMID: 14618415) Mizoguchi M … Louis DN (Neurogenetics 2004) 2 3 58
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 58
  5. SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PMID: 19443465) Spurlock G … Upadhyaya M (Journal of medical genetics 2009) 44 58

Products for SPRED3 Gene

Sources for SPRED3 Gene

Content
Loading form....