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Aliases for OR11L1 Gene

Aliases for OR11L1 Gene

  • Olfactory Receptor Family 11 Subfamily L Member 1 2 3 5
  • Olfactory Receptor, Family 11, Subfamily L, Member 1 2

External Ids for OR11L1 Gene

Previous GeneCards Identifiers for OR11L1 Gene

  • GC01U990419
  • GC01M244305
  • GC01M246070
  • GC01M248004

Summaries for OR11L1 Gene

Entrez Gene Summary for OR11L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11L1 Gene

OR11L1 (Olfactory Receptor Family 11 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR6B1.

UniProtKB/Swiss-Prot for OR11L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR11L1 Gene

Additional gene information for OR11L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11L1 Gene

Genomics for OR11L1 Gene

GeneHancer (GH) Regulatory Elements for OR11L1 Gene

Promoters and enhancers for OR11L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I247854 Enhancer 1.2 FANTOM5 ENCODE 0.4 -13.6 -13611 1.5 ATF1 ARNT TCF12 ZNF766 GATA2 ATF7 NCOA1 ZNF592 SMARCA4 MYNN TRIM58 OR2T8 OR13G1 OR2W3 OR11L1
GH01I247852 Enhancer 0.5 Ensembl 0.4 -10.8 -10805 0.6 MAFF ZNF316 MAFG HMBOX1 NFE2 MAFK EMSY TRIM58 OR2AJ1 OR11L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR11L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR11L1 gene promoter:

Genomic Locations for OR11L1 Gene

Genomic Locations for OR11L1 Gene
969 bases
Minus strand

Genomic View for OR11L1 Gene

Genes around OR11L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11L1 Gene

Proteins for OR11L1 Gene

  • Protein details for OR11L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 11L1
    Protein Accession:

    Protein attributes for OR11L1 Gene

    322 amino acids
    Molecular mass:
    36763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11L1 Gene

Post-translational modifications for OR11L1 Gene

Other Protein References for OR11L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11L1 Gene

Domains & Families for OR11L1 Gene

Gene Families for OR11L1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11L1 Gene

Suggested Antigen Peptide Sequences for OR11L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11L1: view

Function for OR11L1 Gene

Molecular function for OR11L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR11L1 Gene

Gene Ontology (GO) - Molecular Function for OR11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR11L1: view
genes like me logo Genes that share phenotypes with OR11L1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11L1 Gene

Localization for OR11L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11L1 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for OR11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with OR11L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11L1 Gene

Pathways & Interactions for OR11L1 Gene

genes like me logo Genes that share pathways with OR11L1: view

Pathways by source for OR11L1 Gene

Interacting Proteins for OR11L1 Gene

Gene Ontology (GO) - Biological Process for OR11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR11L1: view

No data available for SIGNOR curated interactions for OR11L1 Gene

Drugs & Compounds for OR11L1 Gene

No Compound Related Data Available

Transcripts for OR11L1 Gene

mRNA/cDNA for OR11L1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11L1 Gene

No ASD Table

Relevant External Links for OR11L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR11L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR11L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR11L1 Gene:


SOURCE GeneReport for Unigene cluster for OR11L1 Gene:

genes like me logo Genes that share expression patterns with OR11L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11L1 Gene

Orthologs for OR11L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR11L1 33 34
  • 82.53 (n)
(Mus musculus)
Mammalia Or11l3 51 Olfr323 33 16 34
  • 78.46 (n)
Or5bw2 51 Olfr1350
  • chr7:6,569,993-6,570,916
(Rattus norvegicus)
Mammalia Olr1432 33
  • 77.5 (n)
(Canis familiaris)
Mammalia OR11L1 34
  • 77 (a)
(Monodelphis domestica)
Mammalia OR11L1 34
  • 72 (a)
(Anolis carolinensis)
Reptilia OR11L1 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488665 33
  • 58.09 (n)
(Danio rerio)
Actinopterygii or103-5 34
  • 26 (a)
Species where no ortholog for OR11L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR11L1 Gene

Gene Tree for OR11L1 (if available)
Gene Tree for OR11L1 (if available)

Paralogs for OR11L1 Gene

Paralogs for OR11L1 Gene

(457) SIMAP similar genes for OR11L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR11L1: view

Variants for OR11L1 Gene

Sequence variations from dbSNP and Humsavar for OR11L1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000779934 -- 247,842,681(-) G/A upstream_transcript_variant
rs1002631395 -- 247,842,865(-) TGTGTGTGTGTGTTTGTGTGTGTGTGTGT/TGTGTGTGTGTGT upstream_transcript_variant
rs1005195301 -- 247,842,077(-) T/C upstream_transcript_variant
rs1005637744 -- 247,842,417(-) C/T upstream_transcript_variant
rs1006231240 -- 247,841,129(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for OR11L1 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
nsv1008024 CNV gain 25217958
nsv1010087 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781

Variation tolerance for OR11L1 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11L1 Gene

Disorders for OR11L1 Gene

Additional Disease Information for OR11L1

No disorders were found for OR11L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11L1 Gene

Publications for OR11L1 Gene

  1. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR11L1 Gene

Sources for OR11L1 Gene

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