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Aliases for HES3 Gene

Aliases for HES3 Gene

  • Hes Family BHLH Transcription Factor 3 2 3 5
  • Class B Basic Helix-Loop-Helix Protein 43 3 4
  • Hairy And Enhancer Of Split 3 3 4
  • BHLHb43 3 4
  • Hairy And Enhancer Of Split 3 (Drosophila) 2
  • Transcription Factor HES-3 3
  • BHLHB43 4

External Ids for HES3 Gene

Previous GeneCards Identifiers for HES3 Gene

  • GC01P006237
  • GC01P006304
  • GC01P005452

Summaries for HES3 Gene

GeneCards Summary for HES3 Gene

HES3 (Hes Family BHLH Transcription Factor 3) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protein dimerization activity.

UniProtKB/Swiss-Prot for HES3 Gene

  • Transcriptional repressor of genes that require a bHLH protein for their transcription.

Additional gene information for HES3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HES3 Gene

Genomics for HES3 Gene

GeneHancer (GH) Regulatory Elements for HES3 Gene

Promoters and enhancers for HES3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J006244 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 650.7 +1.6 1580 1.9 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF766 HES3 THAP3 NOL9 GPR153 ZBTB48
GH01J006246 Enhancer 0.6 ENCODE dbSUPER 650.7 0.0 -32 0.2 POLR2A EZH2 HES3 LINC00337
GH01J006245 Enhancer 0.5 ENCODE dbSUPER 650.7 +0.4 418 0.2 EZH2 HES3 GPR153
GH01J006598 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.6 +358.1 358054 6.9 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 KLHL21 PIR47122 THAP3 RPL22 NOL9 HES3 LOC102725193 ZBTB48 PHF13 PIR44711
GH01J006204 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.8 -38.4 -38440 2.9 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B RNF207 LOC102724450 THAP3 HES3 PHF13 ZBTB48 RPL22 NOL9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HES3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HES3 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • STAT3
  • Max1
  • c-Myc
  • ARP-1

Genomic Locations for HES3 Gene

Genomic Locations for HES3 Gene
chr1:6,244,158-6,245,578
(GRCh38/hg38)
Size:
1,421 bases
Orientation:
Plus strand
chr1:6,304,252-6,305,638
(GRCh37/hg19)
Size:
1,387 bases
Orientation:
Plus strand

Genomic View for HES3 Gene

Genes around HES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HES3 Gene

Proteins for HES3 Gene

  • Protein details for HES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGS1-HES3_HUMAN
    Recommended name:
    Transcription factor HES-3
    Protein Accession:
    Q5TGS1
    Secondary Accessions:
    • Q5TGS0

    Protein attributes for HES3 Gene

    Size:
    186 amino acids
    Molecular mass:
    19968 Da
    Quaternary structure:
    • Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
    SequenceCaution:
    • Sequence=CAI19439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for HES3 Gene

Post-translational modifications for HES3 Gene

No Post-translational modifications

Other Protein References for HES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HES3 Gene

Domains & Families for HES3 Gene

Gene Families for HES3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HES3 Gene

Suggested Antigen Peptide Sequences for HES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGS1

UniProtKB/Swiss-Prot:

HES3_HUMAN :
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
Domain:
  • Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  • The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
genes like me logo Genes that share domains with HES3: view

Function for HES3 Gene

Molecular function for HES3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of genes that require a bHLH protein for their transcription.

Phenotypes From GWAS Catalog for HES3 Gene

Gene Ontology (GO) - Molecular Function for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding NAS 17611704
genes like me logo Genes that share ontologies with HES3: view
genes like me logo Genes that share phenotypes with HES3: view

Animal Models for HES3 Gene

MGI Knock Outs for HES3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HES3 Gene

Localization for HES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HES3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HES3 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HES3: view

Pathways & Interactions for HES3 Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with HES3: view

Pathways by source for HES3 Gene

1 KEGG pathway for HES3 Gene

Interacting Proteins for HES3 Gene

Gene Ontology (GO) - Biological Process for HES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0021555 midbrain-hindbrain boundary morphogenesis IEA --
genes like me logo Genes that share ontologies with HES3: view

No data available for SIGNOR curated interactions for HES3 Gene

Drugs & Compounds for HES3 Gene

No Compound Related Data Available

Transcripts for HES3 Gene

mRNA/cDNA for HES3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HES3 Gene

Hairy and enhancer of split 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HES3 Gene

No ASD Table

Relevant External Links for HES3 Gene

GeneLoc Exon Structure for
HES3
ECgene alternative splicing isoforms for
HES3

Expression for HES3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HES3 Gene

This gene is overexpressed in Testis (x27.1), Brain - Spinal cord (cervical c-1) (x6.9), Brain - Amygdala (x5.6), Brain - Substantia nigra (x5.2), and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for HES3 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HES3 Gene



Protein tissue co-expression partners for HES3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HES3 Gene:

HES3

SOURCE GeneReport for Unigene cluster for HES3 Gene:

Hs.532677
genes like me logo Genes that share expression patterns with HES3: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HES3 Gene

Orthologs for HES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HES3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HES3 34 33
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HES3 34 33
  • 81.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HES3 34 33
  • 80.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hes3 16 34 33
  • 74.48 (n)
rat
(Rattus norvegicus)
Mammalia Hes3 33
  • 74.1 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hes3 33
  • 66.28 (n)
zebrafish
(Danio rerio)
Actinopterygii her3 34
  • 27 (a)
OneToOne
Species where no ortholog for HES3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HES3 Gene

ENSEMBL:
Gene Tree for HES3 (if available)
TreeFam:
Gene Tree for HES3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HES3: view image

Paralogs for HES3 Gene

(2) SIMAP similar genes for HES3 Gene using alignment to 1 proteins:

  • HES3_HUMAN
genes like me logo Genes that share paralogs with HES3: view

No data available for Paralogs for HES3 Gene

Variants for HES3 Gene

Sequence variations from dbSNP and Humsavar for HES3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000041902 -- 6,244,851(+) G/C intron_variant
rs1001336111 -- 6,242,577(+) C/T upstream_transcript_variant
rs1001826607 -- 6,245,892(+) C/A/T downstream_transcript_variant
rs1002664761 -- 6,243,055(+) T/G upstream_transcript_variant
rs1002686824 -- 6,242,861(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HES3 Gene

Variant ID Type Subtype PubMed ID
dgv8n67 CNV gain 20364138
nsv508825 CNV insertion 20534489
nsv545236 CNV loss 21841781
nsv545237 CNV loss 21841781
nsv831425 CNV loss 17160897

Variation tolerance for HES3 Gene

Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HES3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HES3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HES3 Gene

Disorders for HES3 Gene

Additional Disease Information for HES3

No disorders were found for HES3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HES3 Gene

Publications for HES3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. (PMID: 15254753) Katoh M … Katoh M (International journal of oncology 2004) 3 4 58
  3. STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System? (PMID: 26783739) Nikolakopoulou P … Androutsellis-Theotokis A (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2016) 3 58
  4. Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. (PMID: 24512568) Economopoulou M … Androutsellis-Theotokis A (International journal of radiation biology 2014) 3 58
  5. Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release. (PMID: 25371201) Masjkur J … Androutsellis-Theotokis A (The Journal of biological chemistry 2014) 3 58

Products for HES3 Gene

Sources for HES3 Gene

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