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Aliases for TMIGD1 Gene

Aliases for TMIGD1 Gene

  • Transmembrane And Immunoglobulin Domain Containing 1 2 3 5
  • TMIGD 3 4
  • Transmembrane And Immunoglobulin Domain-Containing Protein 1 3
  • AWKS9372 3
  • UNQ9372 3

External Ids for TMIGD1 Gene

Previous HGNC Symbols for TMIGD1 Gene


Previous GeneCards Identifiers for TMIGD1 Gene

  • GC17M025669
  • GC17M028643
  • GC17M024853

Summaries for TMIGD1 Gene

GeneCards Summary for TMIGD1 Gene

TMIGD1 (Transmembrane And Immunoglobulin Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMIGD1 Gene

  • May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.

Additional gene information for TMIGD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMIGD1 Gene

Genomics for TMIGD1 Gene

GeneHancer (GH) Regulatory Elements for TMIGD1 Gene

Promoters and enhancers for TMIGD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J030331 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.7 +0.9 878 3 PKNOX1 FOXA2 RAD21 RARA ETV6 ATF7 IKZF2 RUNX3 CREM MIXL1 TMIGD1 BLMH RNU6-1267P CORO6 LOC105371721
GH17J030376 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 10.7 -44.5 -44540 5.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CPD GOSR1 ATAD5 SMURF2P1 SH3GL1P2 ENSG00000265791 LRRC37BP1 CORO6 SUZ12P1 TMIGD1
GH17J030116 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +216.6 216633 2.6 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ENSG00000265394 ENSG00000266919 MIR3184 MIR423 GC17P030118 NSRP1 PIR49703 NUFIP2 CORO6 ENSG00000264456
GH17J030222 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 9.9 +111.0 110969 1.8 GATAD2A HMG20B SAP130 ARID4B DMAP1 RAD21 KAT8 TGIF2 XRCC5 POLR2A SLC6A4 CORO6 ENSG00000252112 RNU6-1267P BLMH TMIGD1 SUZ12P1 GC17P030227 ENSG00000264125
GH17J030395 Enhancer 0.8 ENCODE 11.2 -62.2 -62196 1.6 SOX13 FOXA2 FEZF1 ZNF384 ZNF366 PATZ1 NR2F6 CREM MIXL1 GATAD2A SUZ12P1 TMIGD1 CORO6 BLMH RNU6-1267P GC17P030389 CPD GC17P030463
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMIGD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMIGD1 gene promoter:
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • SRY
  • AML1a
  • TBP

Genomic Locations for TMIGD1 Gene

Genomic Locations for TMIGD1 Gene
17,748 bases
Minus strand
17,727 bases
Minus strand

Genomic View for TMIGD1 Gene

Genes around TMIGD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMIGD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMIGD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMIGD1 Gene

Proteins for TMIGD1 Gene

  • Protein details for TMIGD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and immunoglobulin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K2K1
    • Q6ZMC6

    Protein attributes for TMIGD1 Gene

    262 amino acids
    Molecular mass:
    29185 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for TMIGD1 Gene


neXtProt entry for TMIGD1 Gene

Post-translational modifications for TMIGD1 Gene

  • N-glycosylated.
  • Glycosylation at posLast=190190, posLast=158158, isoforms=2118, posLast=8383, and posLast=5858
  • Modification sites at PhosphoSitePlus

Other Protein References for TMIGD1 Gene

No data available for DME Specific Peptides for TMIGD1 Gene

Domains & Families for TMIGD1 Gene

Gene Families for TMIGD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TMIGD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMIGD1: view

No data available for UniProtKB/Swiss-Prot for TMIGD1 Gene

Function for TMIGD1 Gene

Molecular function for TMIGD1 Gene

UniProtKB/Swiss-Prot Function:
May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.
genes like me logo Genes that share phenotypes with TMIGD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMIGD1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMIGD1 Gene

Localization for TMIGD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD1 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMIGD1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 26342724
GO:0005886 plasma membrane IEA,IDA 26342724
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMIGD1: view

Pathways & Interactions for TMIGD1 Gene

SuperPathways for TMIGD1 Gene

No Data Available

Interacting Proteins for TMIGD1 Gene

Selected Interacting proteins: Q6UXZ0-TMIG1_HUMAN for TMIGD1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030334 regulation of cell migration IDA 26342724
GO:0042127 regulation of cell proliferation IDA 26342724
GO:0043066 negative regulation of apoptotic process IMP 26342724
GO:0090559 regulation of membrane permeability IMP 26342724
genes like me logo Genes that share ontologies with TMIGD1: view

No data available for Pathways by source and SIGNOR curated interactions for TMIGD1 Gene

Drugs & Compounds for TMIGD1 Gene

No Compound Related Data Available

Transcripts for TMIGD1 Gene

mRNA/cDNA for TMIGD1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMIGD1 Gene

Transmembrane and immunoglobulin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD1

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP2: -

Relevant External Links for TMIGD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMIGD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMIGD1 Gene

mRNA differential expression in normal tissues according to GTEx for TMIGD1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.2) and Colon - Transverse (x24.9).

Protein differential expression in normal tissues from HIPED for TMIGD1 Gene

This gene is overexpressed in Breast (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMIGD1 Gene

Protein tissue co-expression partners for TMIGD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMIGD1 Gene:


SOURCE GeneReport for Unigene cluster for TMIGD1 Gene:


Evidence on tissue expression from TISSUES for TMIGD1 Gene

  • Intestine(4.4)
genes like me logo Genes that share expression patterns with TMIGD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMIGD1 Gene

Orthologs for TMIGD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMIGD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMIGD1 34 33
  • 99.49 (n)
(Canis familiaris)
Mammalia TMIGD1 34 33
  • 86.85 (n)
(Bos Taurus)
Mammalia TMIGD1 34 33
  • 83.91 (n)
(Rattus norvegicus)
Mammalia Tmigd1 33
  • 81.32 (n)
(Mus musculus)
Mammalia Tmigd1 16 34 33
  • 78.54 (n)
(Monodelphis domestica)
Mammalia TMIGD1 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TMIGD1 34
  • 61 (a)
(Gallus gallus)
Aves TMIGD1 34 33
  • 60.82 (n)
(Anolis carolinensis)
Reptilia TMIGD1 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmigd1 33
  • 54.39 (n)
(Danio rerio)
Actinopterygii tmigd1 34 33
  • 50.24 (n)
Species where no ortholog for TMIGD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMIGD1 Gene

Gene Tree for TMIGD1 (if available)
Gene Tree for TMIGD1 (if available)
Evolutionary constrained regions (ECRs) for TMIGD1: view image

Paralogs for TMIGD1 Gene

No data available for Paralogs for TMIGD1 Gene

Variants for TMIGD1 Gene

Sequence variations from dbSNP and Humsavar for TMIGD1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000057764 -- 30,317,453(-) A/G intron_variant
rs1000108243 -- 30,317,709(-) GAG/ intron_variant
rs1000297573 -- 30,324,333(-) G/A intron_variant
rs1000595539 -- 30,335,073(-) C/T upstream_transcript_variant
rs1000615328 -- 30,322,452(-) A/C/G intron_variant

Variation tolerance for TMIGD1 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMIGD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMIGD1 Gene

Disorders for TMIGD1 Gene

Additional Disease Information for TMIGD1

No disorders were found for TMIGD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD1 Gene

Publications for TMIGD1 Gene

  1. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. (PMID: 26342724) Arafa E … Rahimi N (The American journal of pathology 2015) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TMIGD1 Gene

  • Biorbyt antibodies for TMIGD1

Sources for TMIGD1 Gene

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