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Aliases for KRT32 Gene

Aliases for KRT32 Gene

  • Keratin 32 2 3 5
  • Hair Keratin, Type I Ha2 3 4
  • Keratin, Hair, Acidic, 2 2 3
  • Keratin 32, Type I 2 3
  • KRTHA2 3 4
  • HKA2 3 4
  • K32 3 4
  • Keratin, Type I Cuticular Ha2 3
  • Type I Cuticular Hair Keratin 3
  • Hard Keratin, Type I, 2 3
  • Hard Keratin Type I 2
  • Keratin-32 4
  • HHa2 3
  • HHA2 4
  • HA2 3

External Ids for KRT32 Gene

Previous HGNC Symbols for KRT32 Gene

  • KRTHA2

Previous GeneCards Identifiers for KRT32 Gene

  • GC17M036870
  • GC17M039615
  • GC17M035379

Summaries for KRT32 Gene

Entrez Gene Summary for KRT32 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT32 Gene

KRT32 (Keratin 32) is a Protein Coding gene. Among its related pathways are Keratinization and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT35.

Gene Wiki entry for KRT32 Gene

Additional gene information for KRT32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT32 Gene

Genomics for KRT32 Gene

GeneHancer (GH) Regulatory Elements for KRT32 Gene

Promoters and enhancers for KRT32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041496 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -28.4 -28433 2.6 HDGF ARNT ZNF2 ZNF48 GLIS2 CBX5 ZNF213 ARID2 ZNF143 ATF7 KRT32 KRT31 LOC100505782 ENSG00000229732 KRT36
GH17J041414 Enhancer 1.1 Ensembl ENCODE 17.5 +50.8 50825 7 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 ZNF48 ETS1 ZNF143 FOS KRT34 KRT32 KRT38 KRT36 KRT31 KRT37 KRT41P LOC100505782
GH17J041377 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 13 +89.3 89283 5.5 JUN CEBPB EP300 RFX5 SREBF1 JUND STAT3 FOXP2 MAFK KRT34 KRT38 KRT32 KRT36 KRT33B
GH17J041464 Enhancer 0.6 ENCODE 17.4 +4.5 4469 1.5 GFI1B ZSCAN4 REST EP300 FOXA1 ZSCAN21 JUND GATA3 ZNF629 SCRT2 KRT32 LOC100505782 KRT34 GC17P041468 KRT43P
GH17J041338 Enhancer 1 Ensembl ENCODE dbSUPER 9.8 +128.2 128241 6 PKNOX1 YBX1 EBF1 MEF2B RELA GATA3 NBN ZNF24 KRT38 KRTAP16-1 KRTAP29-1 KRT31 LOC100505782 KRTAP17-1 KRTAP9-6 KRT37 ENSG00000234477 KRT32
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT32 gene promoter:
  • CHOP-10
  • CUTL1
  • ARP-1
  • Nkx2-5
  • C/EBPalpha
  • Tal-1beta
  • E47

Genomic Locations for KRT32 Gene

Genomic Locations for KRT32 Gene
9,740 bases
Minus strand
7,917 bases
Minus strand

Genomic View for KRT32 Gene

Genes around KRT32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT32 Gene

Proteins for KRT32 Gene

  • Protein details for KRT32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha2
    Protein Accession:

    Protein attributes for KRT32 Gene

    448 amino acids
    Molecular mass:
    50343 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
    • Sequence=CAA57179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KRT32 Gene

Post-translational modifications for KRT32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT32 Gene

Domains & Families for KRT32 Gene

Gene Families for KRT32 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT32: view

Function for KRT32 Gene

Gene Ontology (GO) - Molecular Function for KRT32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT32: view
genes like me logo Genes that share phenotypes with KRT32: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT32 Gene

Localization for KRT32 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT32 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT32 Gene

Pathways & Interactions for KRT32 Gene

genes like me logo Genes that share pathways with KRT32: view

Pathways by source for KRT32 Gene

2 Reactome pathways for KRT32 Gene
1 KEGG pathway for KRT32 Gene

Interacting Proteins for KRT32 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q14532-K1H2_HUMAN ENSP00000225899 for KRT32 Gene via IID STRING

Gene Ontology (GO) - Biological Process for KRT32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 7556444
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT32: view

No data available for SIGNOR curated interactions for KRT32 Gene

Drugs & Compounds for KRT32 Gene

No Compound Related Data Available

Transcripts for KRT32 Gene

mRNA/cDNA for KRT32 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT32 Gene

Keratin 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT32 Gene

No ASD Table

Relevant External Links for KRT32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT32 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x34.1), Skin - Sun Exposed (Lower leg) (x8.0), and Esophagus - Mucosa (x5.1).

Protein differential expression in normal tissues from HIPED for KRT32 Gene

This gene is overexpressed in Cervix (21.9), Skin (15.9), Saliva (11.1), and Bone marrow mesenchymal stem cell (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT32 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT32 Gene:


SOURCE GeneReport for Unigene cluster for KRT32 Gene:


mRNA Expression by UniProt/SwissProt for KRT32 Gene:

Tissue specificity: Restricted to the hair cuticle.

Evidence on tissue expression from TISSUES for KRT32 Gene

  • Skin(4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT32: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT32 Gene

Orthologs for KRT32 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT32 34 33
  • 99.4 (n)
(Canis familiaris)
Mammalia KRT32 34 33
  • 87.21 (n)
(Mus musculus)
Mammalia Krt32 16 34 33
  • 82.07 (n)
(Bos Taurus)
Mammalia KRT32 34 33
  • 81.58 (n)
(Rattus norvegicus)
Mammalia Krt32 33
  • 81.39 (n)
(Monodelphis domestica)
Mammalia KRT32 34
  • 78 (a)
Species where no ortholog for KRT32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT32 Gene

Gene Tree for KRT32 (if available)
Gene Tree for KRT32 (if available)
Evolutionary constrained regions (ECRs) for KRT32: view image

Paralogs for KRT32 Gene

(33) SIMAP similar genes for KRT32 Gene using alignment to 1 proteins:

  • K1H2_HUMAN
genes like me logo Genes that share paralogs with KRT32: view

Variants for KRT32 Gene

Sequence variations from dbSNP and Humsavar for KRT32 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000275820 -- 41,461,852(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000686036 -- 41,467,973(-) T/C genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000709323 -- 41,462,235(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000762442 -- 41,468,204(-) C/A genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000904388 -- 41,463,459(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT32 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789
nsv510711 CNV deletion 20534489

Variation tolerance for KRT32 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.40; 99.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT32 Gene

Disorders for KRT32 Gene

Additional Disease Information for KRT32

No disorders were found for KRT32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT32 Gene

Publications for KRT32 Gene

  1. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PMID: 8823373) Rogers MA … Schweizer J (The Journal of investigative dermatology 1996) 2 3 4 22 58
  2. Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PMID: 7556444) Rogers MA … Schweizer J (Experimental cell research 1995) 2 3 4 58
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  4. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L … Schweizer J (The Journal of biological chemistry 1999) 3 22 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for KRT32 Gene

Sources for KRT32 Gene

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