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Aliases for KIF5B Gene

Aliases for KIF5B Gene

  • Kinesin Family Member 5B 2 3 5
  • Conventional Kinesin Heavy Chain 3 4
  • Ubiquitous Kinesin Heavy Chain 3 4
  • KNS1 3 4
  • UKHC 3 4
  • KNS 3 4
  • Epididymis Secretory Protein Li 61 3
  • Kinesin 1 (110-120kD) 3
  • Kinesin-1 Heavy Chain 3
  • Kinesin Heavy Chain 3
  • HEL-S-61 3
  • KINH 3

External Ids for KIF5B Gene

Previous HGNC Symbols for KIF5B Gene

  • KNS1

Previous GeneCards Identifiers for KIF5B Gene

  • GC10M032448
  • GC10M032304
  • GC10M032340

Summaries for KIF5B Gene

GeneCards Summary for KIF5B Gene

KIF5B (Kinesin Family Member 5B) is a Protein Coding gene. Diseases associated with KIF5B include Adenosquamous Cell Lung Carcinoma and Blackwater Fever. Among its related pathways are Golgi-to-ER retrograde transport and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF5B Gene

  • Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).

Gene Wiki entry for KIF5B Gene

Additional gene information for KIF5B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF5B Gene

Genomics for KIF5B Gene

GeneHancer (GH) Regulatory Elements for KIF5B Gene

Promoters and enhancers for KIF5B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J032947 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650 -899.1 -899114 17.1 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 ZNF610 ITGB1 KIF5B EPC1 LOC105376486 AK3P5 ENSG00000226842 CCDC7 ITGB1-DT
GH10J032053 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 679.2 +1.0 1020 4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 KIF5B ENSG00000206660 GC10P032057 GC10P032002
GH10J031925 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.5 +128.0 127966 5.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ARHGAP12 KIF5B ENSG00000226842 EPC1 ZEB1-AS1 HMGB1P7
GH10J031938 Enhancer 1.4 Ensembl ENCODE dbSUPER 28.2 +114.4 114419 7.3 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 YY1 FOS KLF13 SP5 KIF5B ENSG00000206660 ARHGAP12 GC10P031934 GC10P031969
GH10J032138 Enhancer 1.4 Ensembl ENCODE dbSUPER 17.5 -83.6 -83581 3.4 PKNOX1 ARNT ARID4B SIN3A FOS SP3 REST ZNF592 SREBF1 ZNF610 KIF5B RNU7-22P ENSG00000206660 ENSG00000234811
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF5B gene promoter:
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • Evi-1
  • Elk-1
  • COMP1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for KIF5B Gene

Genomic Locations for KIF5B Gene
chr10:32,009,010-32,056,443
(GRCh38/hg38)
Size:
47,434 bases
Orientation:
Minus strand
chr10:32,297,938-32,345,371
(GRCh37/hg19)
Size:
47,434 bases
Orientation:
Minus strand

Genomic View for KIF5B Gene

Genes around KIF5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF5B Gene

Proteins for KIF5B Gene

  • Protein details for KIF5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33176-KINH_HUMAN
    Recommended name:
    Kinesin-1 heavy chain
    Protein Accession:
    P33176
    Secondary Accessions:
    • A0AVB2
    • Q5VZ85

    Protein attributes for KIF5B Gene

    Size:
    963 amino acids
    Molecular mass:
    109685 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (By similarity). Interacts with SYBU (PubMed:15459722). Interacts with JAKMIP1 (PubMed:17532644). Interacts with PLEKHM2 (PubMed:15905402). Interacts with ECPAS (PubMed:20682791). Interacts with ZFYVE27 (By similarity). Found in a complex with OGT, RHOT1, RHOT2 and TRAK1 (PubMed:24995978).

    Three dimensional structures from OCA and Proteopedia for KIF5B Gene

neXtProt entry for KIF5B Gene

Post-translational modifications for KIF5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KIF5B Gene

Domains & Families for KIF5B Gene

Gene Families for KIF5B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P33176

UniProtKB/Swiss-Prot:

KINH_HUMAN :
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
Domain:
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
genes like me logo Genes that share domains with KIF5B: view

Function for KIF5B Gene

Molecular function for KIF5B Gene

UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).
GENATLAS Biochemistry:
kinesin heavy chain member 5B

Phenotypes From GWAS Catalog for KIF5B Gene

Gene Ontology (GO) - Molecular Function for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity TAS,ISS --
GO:0005515 protein binding IPI 15161933
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding ISS --
genes like me logo Genes that share ontologies with KIF5B: view
genes like me logo Genes that share phenotypes with KIF5B: view

Animal Models for KIF5B Gene

MGI Knock Outs for KIF5B:

miRNA for KIF5B Gene

miRTarBase miRNAs that target KIF5B

Clone Products

  • Addgene plasmids for KIF5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF5B Gene

Localization for KIF5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF5B Gene

Cytoplasm, cytoskeleton. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250 UniProtKB:Q2PQA9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF5B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS 1607388
genes like me logo Genes that share ontologies with KIF5B: view

Pathways & Interactions for KIF5B Gene

genes like me logo Genes that share pathways with KIF5B: view

Pathways by source for KIF5B Gene

SIGNOR curated interactions for KIF5B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement TAS 7514426
GO:0007028 cytoplasm organization IEA --
GO:0007411 axon guidance IBA --
GO:0007420 brain development IEA --
GO:0008104 protein localization IBA --
genes like me logo Genes that share ontologies with KIF5B: view

Drugs & Compounds for KIF5B Gene

(4) Drugs for KIF5B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for KIF5B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KIF5B: view

Transcripts for KIF5B Gene

mRNA/cDNA for KIF5B Gene

(2) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(485) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF5B Gene

Kinesin family member 5B:
Representative Sequences:

Clone Products

  • Addgene plasmids for KIF5B

Alternative Splicing Database (ASD) splice patterns (SP) for KIF5B Gene

No ASD Table

Relevant External Links for KIF5B Gene

GeneLoc Exon Structure for
KIF5B
ECgene alternative splicing isoforms for
KIF5B

Expression for KIF5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF5B Gene



Protein tissue co-expression partners for KIF5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF5B Gene:

KIF5B

SOURCE GeneReport for Unigene cluster for KIF5B Gene:

Hs.327736

Evidence on tissue expression from TISSUES for KIF5B Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Intestine(3.1)
  • Lung(3.1)
  • Skin(2.9)
  • Heart(2.8)
  • Muscle(2.6)
  • Kidney(2.3)
  • Eye(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with KIF5B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF5B Gene

Orthologs for KIF5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF5B 34 33
  • 99.86 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF5B 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF5B 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF5B 34 33
  • 94.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIF5B 34 33
  • 94.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif5b 33
  • 90.69 (n)
mouse
(Mus musculus)
Mammalia Kif5b 16 34 33
  • 90.3 (n)
chicken
(Gallus gallus)
Aves KIF5B 34 33
  • 86.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF5B 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif5b 33
  • 81.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24459 33
zebrafish
(Danio rerio)
Actinopterygii kif5bb 34
  • 86 (a)
OneToMany
kif5ba 34 33
  • 76.17 (n)
OneToMany
wufi31h03 33
fruit fly
(Drosophila melanogaster)
Insecta Khc 34 35 33
  • 58.81 (n)
OneToMany
nod 35
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000561 33
  • 58.8 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-116 34 35 33
  • 58.69 (n)
OneToMany
klp-10 35
  • 28 (a)
klp-18 35
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 62 (a)
OneToMany
Cin.7717 33
bread mold
(Neurospora crassa)
Ascomycetes NCU09730 33
  • 41.51 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7717 33
Species where no ortholog for KIF5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF5B Gene

ENSEMBL:
Gene Tree for KIF5B (if available)
TreeFam:
Gene Tree for KIF5B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF5B: view image

Paralogs for KIF5B Gene

Variants for KIF5B Gene

Sequence variations from dbSNP and Humsavar for KIF5B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000078993 -- 32,027,467(-) G/C intron_variant
rs1000188233 -- 32,050,870(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000246887 -- 32,018,900(-) T/G intron_variant
rs1000256272 -- 32,056,682(-) T/C upstream_transcript_variant
rs1000288354 -- 32,012,987(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF5B Gene

Variant ID Type Subtype PubMed ID
dgv391n106 CNV deletion 24896259
esv1643179 CNV insertion 17803354
esv2572950 CNV insertion 19546169
esv2603542 CNV deletion 19546169
nsv1068683 CNV deletion 25765185
nsv1137893 CNV deletion 24896259
nsv951535 CNV duplication 24416366

Variation tolerance for KIF5B Gene

Residual Variation Intolerance Score: 6.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF5B Gene

Human Gene Mutation Database (HGMD)
KIF5B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF5B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF5B Gene

Disorders for KIF5B Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIF5B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
adenosquamous cell lung carcinoma
  • adenosquamous lung carcinoma
blackwater fever
  • black water fever
- elite association - COSMIC cancer census association via MalaCards
Search KIF5B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF5B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIF5B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF5B Gene

Publications for KIF5B Gene

  1. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. (PMID: 20386726) Splinter D … Akhmanova A (PLoS biology 2010) 3 4 22 58
  2. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. (PMID: 1607388) Navone F … Vale RD (The Journal of cell biology 1992) 2 3 4 58
  3. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C … Rechsteiner M (The Journal of biological chemistry 2010) 3 4 58
  4. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (PMID: 19773350) Trejo HE … Sznajder JI (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 22 58
  5. Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane. (PMID: 19913510) Morton AM … Diefenbach RJ (Biochemical and biophysical research communications 2010) 3 22 58

Products for KIF5B Gene

  • Addgene plasmids for KIF5B

Sources for KIF5B Gene