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Aliases for MIGA1 Gene

Aliases for MIGA1 Gene

  • Mitoguardin 1 2 3 3 5
  • Protein FAM73A 3 4
  • FAM73A 3 4
  • Family With Sequence Similarity 73, Member A 3
  • Family With Sequence Similarity 73 Member A 2

External Ids for MIGA1 Gene

Previous HGNC Symbols for MIGA1 Gene

  • FAM73A

Summaries for MIGA1 Gene

GeneCards Summary for MIGA1 Gene

MIGA1 (Mitoguardin 1) is a Protein Coding gene. An important paralog of this gene is MIGA2.

UniProtKB/Swiss-Prot for MIGA1 Gene

  • Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Additional gene information for MIGA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIGA1 Gene

Genomics for MIGA1 Gene

GeneHancer (GH) Regulatory Elements for MIGA1 Gene

Promoters and enhancers for MIGA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J077778 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 184 1.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 MIGA1 RNA5SP21 GIPC2
GH01J077829 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 +52.9 52919 6.5 FOXA2 PKNOX1 CLOCK BMI1 GATA3 POLR2A PRDM10 NFE2 TCF7L2 RFX1 MIGA1 RNA5SP21 ACTG1P21 USP33 IFI44 NEXN FUBP1 NSRP1P1 LOC653631
GH01J077823 Enhancer 1 Ensembl ENCODE dbSUPER 11.5 +45.4 45394 2.4 SCRT1 CTCF JUN HLF CEBPB CEBPG RAD21 JUND SCRT2 MYNN MIGA1 RNA5SP21 ACTG1P21 LOC653631 NSRP1P1
GH01J078070 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.4 +291.7 291726 2.1 PKNOX1 ARNT JUN FEZF1 YY1 POLR2A FOSL2 FOS RXRA JUNB GIPC2 ACTG1P21 MIGA1 RNA5SP21 IFI44 RNU6-1102P LOC100131495
GH01J077926 Promoter 0.9 Ensembl 10.8 +147.2 147179 0.4 ATF4 L3MBTL2 ZNF512 JUNB ZSCAN29 CEBPG RUNX3 PRDM1 GIPC2 RNA5SP21 MIGA1 ACTG1P21 NEXN-AS1 NEXN DNAJB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIGA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIGA1 Gene

Genomic Locations for MIGA1 Gene
chr1:77,779,622-77,879,540
(GRCh38/hg38)
Size:
99,919 bases
Orientation:
Plus strand
chr1:78,245,309-78,344,106
(GRCh37/hg19)
Size:
98,798 bases
Orientation:
Plus strand

Genomic View for MIGA1 Gene

Genes around MIGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIGA1 Gene

Proteins for MIGA1 Gene

  • Protein details for MIGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAN2-MIGA1_HUMAN
    Recommended name:
    Mitoguardin 1
    Protein Accession:
    Q8NAN2
    Secondary Accessions:
    • Q6MZG0

    Protein attributes for MIGA1 Gene

    Size:
    632 amino acids
    Molecular mass:
    71006 Da
    Quaternary structure:
    • Homodimer and heterodimer; forms heterodimers with MIGA2 (PubMed:26711011). Interacts with PLD6/MitoPLD (PubMed:26711011).

    Alternative splice isoforms for MIGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIGA1 Gene

Post-translational modifications for MIGA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIGA1 Gene

Domains & Families for MIGA1 Gene

Gene Families for MIGA1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MIGA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIGA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAN2

UniProtKB/Swiss-Prot:

MIGA1_HUMAN :
  • Belongs to the mitoguardin family.
Family:
  • Belongs to the mitoguardin family.
genes like me logo Genes that share domains with MIGA1: view

Function for MIGA1 Gene

Molecular function for MIGA1 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

Phenotypes From GWAS Catalog for MIGA1 Gene

Gene Ontology (GO) - Molecular Function for MIGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26711011
GO:0042803 protein homodimerization activity IDA 26711011
GO:0046982 protein heterodimerization activity IDA 26711011
genes like me logo Genes that share ontologies with MIGA1: view
genes like me logo Genes that share phenotypes with MIGA1: view

Animal Models for MIGA1 Gene

MGI Knock Outs for MIGA1:
  • Miga1 Miga1<tm1b(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIGA1 Gene

Localization for MIGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIGA1 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIGA1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005887 integral component of plasma membrane IDA 26711011
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIGA1: view

Pathways & Interactions for MIGA1 Gene

SuperPathways for MIGA1 Gene

No Data Available

Interacting Proteins for MIGA1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359827%0d%0a9606.ENSP00000368332%0d%0a
Selected Interacting proteins: Q8NAN2-MIGA1_HUMAN ENSP00000359827 for MIGA1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MIGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008053 mitochondrial fusion IEA,IDA 26711011
genes like me logo Genes that share ontologies with MIGA1: view

No data available for Pathways by source and SIGNOR curated interactions for MIGA1 Gene

Drugs & Compounds for MIGA1 Gene

No Compound Related Data Available

Transcripts for MIGA1 Gene

mRNA/cDNA for MIGA1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIGA1 Gene

No ASD Table

Relevant External Links for MIGA1 Gene

GeneLoc Exon Structure for
MIGA1
ECgene alternative splicing isoforms for
MIGA1

Expression for MIGA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIGA1 Gene:

MIGA1

Evidence on tissue expression from TISSUES for MIGA1 Gene

  • Nervous system(4.6)
  • Liver(4.1)
  • Kidney(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIGA1 Gene

Orthologs for MIGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM73A 34 33
  • 99.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM73A 34 33
  • 92.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM73A 34 33
  • 92.22 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM73A 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam73a 34 33
  • 84.06 (n)
OneToOne
Miga1 16
rat
(Rattus norvegicus)
Mammalia Fam73a 33
  • 81.13 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM73A 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM73A 34 33
  • 80.3 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM73A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam73a 33
  • 69.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fam73a 34 33
  • 63.32 (n)
OneToOne
Dr.18613 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1985 33
fruit fly
(Drosophila melanogaster)
Insecta CG12125 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K01D12.6 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for MIGA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIGA1 Gene

ENSEMBL:
Gene Tree for MIGA1 (if available)
TreeFam:
Gene Tree for MIGA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIGA1: view image

Paralogs for MIGA1 Gene

Paralogs for MIGA1 Gene

genes like me logo Genes that share paralogs with MIGA1: view

Variants for MIGA1 Gene

Sequence variations from dbSNP and Humsavar for MIGA1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000914 -- 77,867,608(+) G/T intron_variant
rs1000004897 -- 77,866,083(+) T/A intron_variant
rs1000005483 -- 77,778,691(+) TTTTTT/TTTTTTT upstream_transcript_variant
rs1000073221 -- 77,848,391(+) A/G intron_variant
rs1000080710 -- 77,874,217(+) G/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIGA1 Gene

Variant ID Type Subtype PubMed ID
esv2674622 CNV deletion 23128226
esv3586530 CNV loss 21293372
nsv470719 CNV gain 18288195
nsv546591 CNV gain 21841781
nsv830303 CNV loss 17160897
nsv946006 CNV duplication 23825009
nsv946007 CNV duplication 23825009
nsv947433 CNV duplication 23825009

Variation tolerance for MIGA1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIGA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIGA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIGA1 Gene

Disorders for MIGA1 Gene

No disorders were found for MIGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIGA1 Gene

Publications for MIGA1 Gene

  1. Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. (PMID: 26716412) Liu XM … Fan HY (Oncotarget 2016) 2 3 58
  2. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. (PMID: 26711011) Zhang Y … Tong C (Molecular cell 2016) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MIGA1 Gene

Sources for MIGA1 Gene

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