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Aliases for JUNB Gene

Aliases for JUNB Gene

  • JunB Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • Transcription Factor Jun-B 3
  • Jun B Proto-Oncogene 3
  • Activator Protein 1 3
  • AP-1 3

External Ids for JUNB Gene

Previous GeneCards Identifiers for JUNB Gene

  • GC19P013033
  • GC19P013125
  • GC19P012747
  • GC19P012763
  • GC19P012902
  • GC19P012474

Summaries for JUNB Gene

GeneCards Summary for JUNB Gene

JUNB (JunB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUNB include Anaplastic Large Cell Lymphoma and Fumarate Hydratase Deficiency. Among its related pathways are ERK Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot for JUNB Gene

  • Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5-TGA[CG]TCA-3.

Gene Wiki entry for JUNB Gene

Additional gene information for JUNB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUNB Gene

Genomics for JUNB Gene

GeneHancer (GH) Regulatory Elements for JUNB Gene

Promoters and enhancers for JUNB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012609 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 13.7 -179.1 -179135 4.8 ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 ZNF490 ZNF791 PIR37932 ZNF136 ZNF44 ZNF442 ZNF20 ZNF844 ZNF700 ZNF564
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 -2.2 -2198 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 IER2 ZNF136 CCDC130 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 ZNF700
GH19J013148 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 +362.2 362199 10.2 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX10 IER2 ENSG00000267598 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS ZNF791
GH19J012293 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 6.6 -497.0 -496979 2.9 PKNOX1 MLX ARID4B SIN3A YY1 POLR2B ZNF766 CBX5 ZNF143 FOS ZNF44 ZNF136 ZNF20 ZNF700 ZNF763 ZNF564 ZNF878 TRMT1 TRIR ZNF627
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JUNB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JUNB gene promoter:
  • SRF
  • SRF (504 AA)
  • Egr-1
  • AP-1

Genomic Locations for JUNB Gene

Genomic Locations for JUNB Gene
1,820 bases
Plus strand
1,816 bases
Plus strand

Genomic View for JUNB Gene

Genes around JUNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUNB Gene

Proteins for JUNB Gene

  • Protein details for JUNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor jun-B
    Protein Accession:
    Secondary Accessions:
    • Q96GH3

    Protein attributes for JUNB Gene

    347 amino acids
    Molecular mass:
    35879 Da
    Quaternary structure:
    • Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

neXtProt entry for JUNB Gene

Post-translational modifications for JUNB Gene

Other Protein References for JUNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JUNB Gene

Domains & Families for JUNB Gene

Gene Families for JUNB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for JUNB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bZIP family. Jun subfamily.
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUNB: view

Function for JUNB Gene

Molecular function for JUNB Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5-TGA[CG]TCA-3.
UniProtKB/Swiss-Prot Induction:
By growth factors.
GENATLAS Biochemistry:
jun protooncogene homolog B,ligand induced,immediate (primary) early response gene

Phenotypes From GWAS Catalog for JUNB Gene

Gene Ontology (GO) - Molecular Function for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA,IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA,NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding TAS 10764760
genes like me logo Genes that share ontologies with JUNB: view
genes like me logo Genes that share phenotypes with JUNB: view

Animal Model Products

Transcription Factor Targets for JUNB Gene

Selected GeneGlobe predicted Target genes for JUNB

Clone Products

  • Addgene plasmids for JUNB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for JUNB Gene

Localization for JUNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUNB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUNB gene
Compartment Confidence
nucleus 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 2513129
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with JUNB: view

Pathways & Interactions for JUNB Gene

genes like me logo Genes that share pathways with JUNB: view

SIGNOR curated interactions for JUNB Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0001570 vasculogenesis IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001829 trophectodermal cell differentiation IEA --
genes like me logo Genes that share ontologies with JUNB: view

Drugs & Compounds for JUNB Gene

(38) Drugs for JUNB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(19) Additional Compounds for JUNB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUNB: view

Transcripts for JUNB Gene

mRNA/cDNA for JUNB Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(667) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUNB Gene

Jun B proto-oncogene:
Representative Sequences:

Clone Products

  • Addgene plasmids for JUNB

Alternative Splicing Database (ASD) splice patterns (SP) for JUNB Gene

No ASD Table

Relevant External Links for JUNB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JUNB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JUNB Gene

mRNA differential expression in normal tissues according to GTEx for JUNB Gene

This gene is overexpressed in Fallopian Tube (x4.9).

Protein differential expression in normal tissues from HIPED for JUNB Gene

This gene is overexpressed in Placenta (19.9), Peripheral blood mononuclear cells (18.5), CD8 Tcells (13.7), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JUNB Gene

Protein tissue co-expression partners for JUNB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JUNB Gene:


SOURCE GeneReport for Unigene cluster for JUNB Gene:


Evidence on tissue expression from TISSUES for JUNB Gene

  • Pancreas(4.6)
  • Nervous system(3.8)
  • Lung(3.2)
  • Intestine(3.1)
  • Muscle(3.1)
  • Kidney(2.9)
  • Skin(2.8)
  • Blood(2.7)
  • Bone marrow(2.6)
  • Liver(2.6)
  • Heart(2.5)
  • Adrenal gland(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with JUNB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUNB Gene

Orthologs for JUNB Gene

This gene was present in the common ancestor of animals.

Orthologs for JUNB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia JUNB 34 33
  • 99.9 (n)
(Canis familiaris)
Mammalia JUNB 34 33
  • 92.89 (n)
(Bos Taurus)
Mammalia JUNB 34 33
  • 92.7 (n)
(Mus musculus)
Mammalia Junb 16 34 33
  • 88.95 (n)
(Rattus norvegicus)
Mammalia Junb 33
  • 88.47 (n)
(Ornithorhynchus anatinus)
Mammalia JUNB 34
  • 74 (a)
(Anolis carolinensis)
Reptilia JUNB 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia junb 33
  • 60 (n)
(Danio rerio)
Actinopterygii junba 34
  • 58 (a)
junbb 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jra 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for JUNB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUNB Gene

Gene Tree for JUNB (if available)
Gene Tree for JUNB (if available)
Evolutionary constrained regions (ECRs) for JUNB: view image

Paralogs for JUNB Gene

Paralogs for JUNB Gene

(3) SIMAP similar genes for JUNB Gene using alignment to 3 proteins:

  • Q5U079_HUMAN
genes like me logo Genes that share paralogs with JUNB: view

Variants for JUNB Gene

Sequence variations from dbSNP and Humsavar for JUNB Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000901426 -- 12,790,070(+) C/T upstream_transcript_variant
rs1001278645 -- 12,793,554(+) T/G downstream_transcript_variant
rs1001569409 -- 12,793,185(+) T/C 3_prime_UTR_variant
rs1002071250 -- 12,792,427(+) C/T coding_sequence_variant, missense_variant
rs1002097621 -- 12,792,999(+) T/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for JUNB Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for JUNB Gene

Gene Damage Index Score: 0.72; 15.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JUNB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUNB Gene

Disorders for JUNB Gene

MalaCards: The human disease database

(3) MalaCards diseases for JUNB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anaplastic large cell lymphoma
  • alcl
fumarate hydratase deficiency
  • fumarase deficiency
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search JUNB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JUNB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JUNB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUNB Gene

Publications for JUNB Gene

  1. jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. (PMID: 2513129) Schütte J … Minna J (Cell 1989) 2 3 4 58
  2. Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. (PMID: 20132737) Son YO … Lee JC (BMB reports 2010) 3 22 58
  3. Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PMID: 19666408) Guo C … Yang X (Hepatobiliary & pancreatic diseases international : HBPD INT 2009) 3 22 58
  4. [Methylation status of JunB and CDH13 gene promoter in CD34(+)CD38(-) chronic myelogenous leukemia cells]. (PMID: 20030915) Wang XJ … Huang SA (Zhongguo shi yan xue ye xue za zhi 2009) 3 22 58
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58

Products for JUNB Gene

Sources for JUNB Gene