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Aliases for JAK1 Gene

Aliases for JAK1 Gene

  • Janus Kinase 1 2 3 4 5
  • JAK1B 3 4
  • JAK1A 3 4
  • Tyrosine-Protein Kinase JAK1 3
  • EC 2.7.10.2 4
  • JAK-1 4
  • JTK3 3

External Ids for JAK1 Gene

Previous HGNC Symbols for JAK1 Gene

  • JAK1B

Previous GeneCards Identifiers for JAK1 Gene

  • GC01M065247
  • GC01M064219
  • GC01M064656
  • GC01M064670
  • GC01M064668
  • GC01M065010
  • GC01M063407

Summaries for JAK1 Gene

Entrez Gene Summary for JAK1 Gene

  • This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

CIViC summary for JAK1 Gene

GeneCards Summary for JAK1 Gene

JAK1 (Janus Kinase 1) is a Protein Coding gene. Diseases associated with JAK1 include Leukemia, Acute, X-Linked and Polycythemia Vera. Among its related pathways are Akt Signaling and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TYK2.

UniProtKB/Swiss-Prot for JAK1 Gene

  • Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).

Gene Wiki entry for JAK1 Gene

Additional gene information for JAK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAK1 Gene

Genomics for JAK1 Gene

GeneHancer (GH) Regulatory Elements for JAK1 Gene

Promoters and enhancers for JAK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J064914 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.1 +50.0 50046 3.9 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 FOS ATF7 RXRA GC01P064919 LOC100130270 JAK1 RAVER2 GC01P064910
GH01J064919 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24.6 +45.2 45223 3.9 FOXA2 BMI1 ZBTB40 TCF12 ATF7 RCOR1 FOS RUNX3 CEBPB NFIL3 JAK1 AK4 RAVER2 GC01P064919 GC01M064928
GH01J064896 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +68.8 68778 3.1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YY1 FOS REST JAK1 RNU6-1176P AK4 RAVER2 GC01M064894 GC01P064883
GH01J064932 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 22 +33.1 33075 2.8 FOXA2 SIN3A ZBTB40 YY1 ZSCAN5C ATF7 FOS KLF13 RXRA CEBPB JAK1 MIR101-1 AK4 LEPROT LEPR GC01M064928 GC01P064919
GH01J064863 Enhancer 1.4 Ensembl ENCODE dbSUPER 23 +102.1 102092 2.4 PKNOX1 SMAD1 ARNT IRF4 ZNF766 CBX5 E2F8 ZNF207 ZNF143 JUNB JAK1 RAVER2 GC01P064868 GC01M064851
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around JAK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JAK1 gene promoter:
  • POU2F1
  • POU2F2C
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • ZID

Genomic Locations for JAK1 Gene

Genomic Locations for JAK1 Gene
chr1:64,833,223-64,966,910
(GRCh38/hg38)
Size:
133,688 bases
Orientation:
Minus strand
chr1:65,298,906-65,432,187
(GRCh37/hg19)
Size:
133,282 bases
Orientation:
Minus strand

Genomic View for JAK1 Gene

Genes around JAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAK1 Gene

Proteins for JAK1 Gene

  • Protein details for JAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23458-JAK1_HUMAN
    Recommended name:
    Tyrosine-protein kinase JAK1
    Protein Accession:
    P23458
    Secondary Accessions:
    • Q59GQ2
    • Q9UD26

    Protein attributes for JAK1 Gene

    Size:
    1154 amino acids
    Molecular mass:
    133277 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with IL31RA (PubMed:15194700). Interacts with IFNAR2 (PubMed:7759950). Interacts with IFNGR1 (PubMed:7615558). Interacts with JAKMIP1 (PubMed:15277531). Interacts with SHB (PubMed:12200137). Interacts with FER (By similarity).
    SequenceCaution:
    • Sequence=AAA36527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA36527.1; Type=Frameshift; Positions=858, 862; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JAK1 Gene

neXtProt entry for JAK1 Gene

Post-translational modifications for JAK1 Gene

  • Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).
  • Ubiquitinated by RNF125; leading to its degradation by the proteasome.
  • Ubiquitination at isoforms=269, Lys249, isoforms=245, Lys227, and isoforms=213
  • Modification sites at PhosphoSitePlus

Other Protein References for JAK1 Gene

No data available for DME Specific Peptides for JAK1 Gene

Domains & Families for JAK1 Gene

Gene Families for JAK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for JAK1 Gene

Graphical View of Domain Structure for InterPro Entry

P23458

UniProtKB/Swiss-Prot:

JAK1_HUMAN :
  • Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Domain:
  • Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.
  • The FERM domain mediates interaction with JAKMIP1.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
genes like me logo Genes that share domains with JAK1: view

Function for JAK1 Gene

Molecular function for JAK1 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
GENATLAS Biochemistry:
Janus tyrosine kinase 1A,non receptor type,class III,murine FD-22 homolog,widely expressed,involved in signal transduction of several hematopoietic cytokine receptors,mediating the activation of STAT proteins

Enzyme Numbers (IUBMB) for JAK1 Gene

Phenotypes From GWAS Catalog for JAK1 Gene

Gene Ontology (GO) - Molecular Function for JAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA,TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with JAK1: view
genes like me logo Genes that share phenotypes with JAK1: view

Animal Models for JAK1 Gene

MGI Knock Outs for JAK1:

Animal Model Products

Clone Products

  • Addgene plasmids for JAK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JAK1 Gene

Localization for JAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAK1 Gene

Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAK1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endosome 4
cytoskeleton 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for JAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10502458
GO:0005737 cytoplasm IDA 10502458
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with JAK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for JAK1 Gene

Pathways & Interactions for JAK1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
3 Th17 cell differentiation
4 Influenza A
.33
5 Th1 Differentiation Pathway
genes like me logo Genes that share pathways with JAK1: view

Pathways by source for JAK1 Gene

SIGNOR curated interactions for JAK1 Gene

Gene Ontology (GO) - Biological Process for JAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation TAS 1848670
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration IBA --
genes like me logo Genes that share ontologies with JAK1: view

Drugs & Compounds for JAK1 Gene

(54) Drugs for JAK1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Baricitinib Approved, Investigational Pharma Target, inhibitor 0
ruxolitinib Approved Pharma inhibitor, Target Kinase Inhibitors 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Tofacitinib Approved, Investigational Pharma Target, inhibitor 112
2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Experimental Pharma Target 0

(17) Additional Compounds for JAK1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with JAK1: view

Transcripts for JAK1 Gene

Unigene Clusters for JAK1 Gene

Janus kinase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for JAK1

Alternative Splicing Database (ASD) splice patterns (SP) for JAK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: - - - -
SP2:
SP3: - - -
SP4: -
SP5: -
SP6: - -
SP7:
SP8:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for JAK1 Gene

GeneLoc Exon Structure for
JAK1
ECgene alternative splicing isoforms for
JAK1

Expression for JAK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JAK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JAK1 Gene

This gene is overexpressed in Lymph node (15.9), Peripheral blood mononuclear cells (15.6), and Adrenal (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for JAK1 Gene



Protein tissue co-expression partners for JAK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JAK1 Gene:

JAK1

SOURCE GeneReport for Unigene cluster for JAK1 Gene:

Hs.207538

mRNA Expression by UniProt/SwissProt for JAK1 Gene:

P23458-JAK1_HUMAN
Tissue specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

Evidence on tissue expression from TISSUES for JAK1 Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Blood(3.3)
  • Spleen(3.3)
  • Heart(2.9)
  • Lung(2.9)
  • Kidney(2.7)
  • Muscle(2.7)
  • Bone marrow(2.6)
  • Intestine(2.5)
  • Lymph node(2.5)
  • Skin(2.5)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with JAK1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAK1 Gene

Orthologs for JAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for JAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JAK1 34 33
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia JAK1 34 33
  • 92.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia JAK1 34 33
  • 91.85 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Jak1 16 34 33
  • 89.5 (n)
rat
(Rattus norvegicus)
Mammalia Jak1 33
  • 89.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia JAK1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves JAK1 34 33
  • 75.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia jak1 33
  • 71.83 (n)
Str.19081 33
zebrafish
(Danio rerio)
Actinopterygii jak1 34 33 33
  • 64.52 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9095 33
worm
(Caenorhabditis elegans)
Secernentea T14E8.1b 35
  • 32 (a)
T14E8.1a 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for JAK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JAK1 Gene

ENSEMBL:
Gene Tree for JAK1 (if available)
TreeFam:
Gene Tree for JAK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for JAK1: view image

Paralogs for JAK1 Gene

Paralogs for JAK1 Gene

(13) SIMAP similar genes for JAK1 Gene using alignment to 5 proteins:

  • JAK1_HUMAN
  • Q0VGA4_HUMAN
  • Q4LDX3_HUMAN
  • Q6P669_HUMAN
  • Q8IV82_HUMAN
genes like me logo Genes that share paralogs with JAK1: view

Variants for JAK1 Gene

Sequence variations from dbSNP and Humsavar for JAK1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1057519753 likely-pathogenic, Leukemia, acute, ?X-linked, Polycythemia vera, Acute myeloid leukemia, Lymphoblastic leukemia, acute, with lymphomatous features 64,846,664(-) C/A coding_sequence_variant, missense_variant
rs151047872 likely-pathogenic, Lymphoblastic leukemia, acute, with lymphomatous features 64,846,699(-) G/A coding_sequence_variant, missense_variant
rs869312953 likely-pathogenic, Inborn genetic diseases, Lymphoblastic leukemia, acute, with lymphomatous features 64,846,735(-) G/T coding_sequence_variant, missense_variant
rs149968614 not-provided, not specified 64,846,685(-) C/T coding_sequence_variant, missense_variant
rs187043211 not-provided, not specified 64,841,507(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for JAK1 Gene

Variant ID Type Subtype PubMed ID
dgv172n100 CNV gain 25217958
esv2421783 CNV deletion 20811451
esv2671749 CNV deletion 23128226
esv275588 CNV loss 21479260
esv2763311 CNV gain 21179565
esv3577904 CNV loss 25503493
esv3578582 CNV gain 25503493
esv3586273 CNV loss 21293372
nsv1005169 CNV gain 25217958
nsv1006347 CNV gain+loss 25217958
nsv1126199 CNV deletion 24896259
nsv525227 CNV loss 19592680
nsv823098 CNV loss 20364138
nsv830059 CNV loss 17160897
nsv945979 CNV duplication 23825009

Variation tolerance for JAK1 Gene

Residual Variation Intolerance Score: 4.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JAK1 Gene

Human Gene Mutation Database (HGMD)
JAK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JAK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAK1 Gene

Disorders for JAK1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for JAK1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute, x-linked
polycythemia vera
  • pv
polycythemia
  • polycythemia vera
hepatitis c
  • chronic hepatitis c
jak3-deficient severe combined immunodeficiency
  • autosomal recessive t cell-negative, b cell-positive, nk cell-negative severe combined immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search JAK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JAK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JAK1 Gene

Publications for JAK1 Gene

  1. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. (PMID: 1848670) Wilks AF … Ziemiecki A (Molecular and cellular biology 1991) 2 3 4 22 58
  2. Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. (PMID: 19361440) Williams NK … Lucet IS (Journal of molecular biology 2009) 3 4 22 58
  3. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. (PMID: 18362173) Flex E … Tartaglia M (The Journal of experimental medicine 2008) 3 22 44 58
  4. The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. (PMID: 7615558) Sakatsume M … Finbloom DS (The Journal of biological chemistry 1995) 3 4 22 58
  5. Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. (PMID: 26027934) Kim H … Ronai ZA (Cell reports 2015) 3 4 58

Products for JAK1 Gene

Sources for JAK1 Gene