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Aliases for INHBC Gene

Aliases for INHBC Gene

  • Inhibin Subunit Beta C 2 3
  • Inhibin Beta C Subunit 3 5
  • Activin Beta-C Chain 3 4
  • Inhibin Beta C Chain 3
  • Inhibin, Beta C 2
  • IHBC 3

External Ids for INHBC Gene

Previous GeneCards Identifiers for INHBC Gene

  • GC12P059241
  • GC12P057971
  • GC12P057545
  • GC12P056114
  • GC12P057828
  • GC12P054866

Summaries for INHBC Gene

Entrez Gene Summary for INHBC Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHBC Gene

INHBC (Inhibin Subunit Beta C) is a Protein Coding gene. Among its related pathways are TGF-beta signaling pathway (KEGG) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is INHBE.

UniProtKB/Swiss-Prot for INHBC Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHBC Gene

Additional gene information for INHBC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBC Gene

Genomics for INHBC Gene

GeneHancer (GH) Regulatory Elements for INHBC Gene

Promoters and enhancers for INHBC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057435 Promoter/Enhancer 1.3 EPDnew ENCODE 650.7 +0.6 616 1.1 ELF3 ZFP64 ARID4B RAD21 YY1 EGR1 RUNX3 RXRA CEBPB ELF1 INHBC R3HDM2 ATP23 GC12P057451 PIR49376
GH12J057434 Promoter 1 EPDnew 650.7 0.0 -19 0.1 DRAP1 TFAP4 TAF1 SAP130 ZFP64 ARID4B MAX RAD21 YY1 EGR1 INHBC ENSG00000258001
GH12J057450 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.4 +17.4 17376 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 ZNF207 INHBE ENSG00000224713 PIR49376 GC12P057451 INHBC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INHBC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INHBC gene promoter:
  • Nkx2-5
  • C/EBPbeta
  • c-Jun
  • c-Fos
  • AP-1
  • STAT5A
  • GR
  • GR-alpha

Genomic Locations for INHBC Gene

Genomic Locations for INHBC Gene
chr12:57,434,685-57,452,062
(GRCh38/hg38)
Size:
17,378 bases
Orientation:
Plus strand
chr12:57,828,543-57,844,611
(GRCh37/hg19)
Size:
16,069 bases
Orientation:
Plus strand

Genomic View for INHBC Gene

Genes around INHBC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBC Gene

Proteins for INHBC Gene

  • Protein details for INHBC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55103-INHBC_HUMAN
    Recommended name:
    Inhibin beta C chain
    Protein Accession:
    P55103
    Secondary Accessions:
    • A1L3Y2

    Protein attributes for INHBC Gene

    Size:
    352 amino acids
    Molecular mass:
    38238 Da
    Quaternary structure:
    • Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).

neXtProt entry for INHBC Gene

Post-translational modifications for INHBC Gene

  • Glycosylation at Asn161, Asn143, and Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBC Gene

Domains & Families for INHBC Gene

Gene Families for INHBC Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for INHBC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55103

UniProtKB/Swiss-Prot:

INHBC_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBC: view

Function for INHBC Gene

Molecular function for INHBC Gene

UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GENATLAS Biochemistry:
inhibitin,beta C,murine homolog,TGFB superfamily member

Phenotypes From GWAS Catalog for INHBC Gene

Gene Ontology (GO) - Molecular Function for INHBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding TAS 7826378
GO:0005179 hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with INHBC: view
genes like me logo Genes that share phenotypes with INHBC: view

Animal Models for INHBC Gene

MGI Knock Outs for INHBC:

Animal Model Products

  • Taconic Biosciences Mouse Models for INHBC

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for INHBC Gene

Localization for INHBC Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for INHBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7826378
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with INHBC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INHBC Gene

Pathways & Interactions for INHBC Gene

genes like me logo Genes that share pathways with INHBC: view

Gene Ontology (GO) - Biological Process for INHBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0042981 regulation of apoptotic process IBA --
GO:0043408 regulation of MAPK cascade IBA --
GO:0048468 cell development IBA --
genes like me logo Genes that share ontologies with INHBC: view

No data available for SIGNOR curated interactions for INHBC Gene

Drugs & Compounds for INHBC Gene

No Compound Related Data Available

Transcripts for INHBC Gene

mRNA/cDNA for INHBC Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INHBC Gene

Inhibin, beta C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBC

Alternative Splicing Database (ASD) splice patterns (SP) for INHBC Gene

No ASD Table

Relevant External Links for INHBC Gene

GeneLoc Exon Structure for
INHBC
ECgene alternative splicing isoforms for
INHBC

Expression for INHBC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INHBC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBC Gene

This gene is overexpressed in Liver (x49.6).

Protein differential expression in normal tissues from HIPED for INHBC Gene

This gene is overexpressed in Serum (44.8) and Plasma (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INHBC Gene



Protein tissue co-expression partners for INHBC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INHBC Gene:

INHBC

SOURCE GeneReport for Unigene cluster for INHBC Gene:

Hs.632722

mRNA Expression by UniProt/SwissProt for INHBC Gene:

P55103-INHBC_HUMAN
Tissue specificity: Expressed in benign prostatic hyperplasia.

Evidence on tissue expression from TISSUES for INHBC Gene

  • Liver(4.6)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with INHBC: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBC Gene

Orthologs for INHBC Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBC 34 33
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia INHBC 34 33
  • 86.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia INHBC 34 33
  • 83.81 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhbc 33
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Inhbc 16 34 33
  • 81.1 (n)
oppossum
(Monodelphis domestica)
Mammalia INHBC 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493888 33
  • 51.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia actd-A-prov 33
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 34
  • 10 (a)
OneToMany
Species where no ortholog for INHBC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INHBC Gene

ENSEMBL:
Gene Tree for INHBC (if available)
TreeFam:
Gene Tree for INHBC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INHBC: view image

Paralogs for INHBC Gene

(3) SIMAP similar genes for INHBC Gene using alignment to 1 proteins:

  • INHBC_HUMAN
genes like me logo Genes that share paralogs with INHBC: view

Variants for INHBC Gene

Sequence variations from dbSNP and Humsavar for INHBC Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000015848 -- 57,442,281(+) C/T intron_variant
rs1000044471 -- 57,434,450(+) C/T upstream_transcript_variant
rs1000089016 -- 57,442,628(+) A/G intron_variant
rs1000123473 -- 57,435,066(+) C/T coding_sequence_variant, synonymous_variant
rs1000189606 -- 57,433,545(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for INHBC Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789

Variation tolerance for INHBC Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INHBC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHBC Gene

Disorders for INHBC Gene

Additional Disease Information for INHBC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for INHBC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INHBC Gene

Publications for INHBC Gene

  1. Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. (PMID: 7826378) H tten G … Pohl J (Biochemical and biophysical research communications 1995) 2 3 4 22 58
  2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 22 44 58
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  4. Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. (PMID: 19095948) Gold E … Risbridger G (The American journal of pathology 2009) 3 22 58
  5. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PMID: 19064572) Palmieri RT … Australian Ovarian Cancer Study Group (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 44 58

Products for INHBC Gene

Sources for INHBC Gene

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