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Aliases for ING2 Gene

Aliases for ING2 Gene

  • Inhibitor Of Growth Family Member 2 2 3 5
  • Inhibitor Of Growth 1-Like Protein 3 4
  • P33ING2 3 4
  • ING1Lp 3 4
  • ING1L 3 4
  • P32 3 4
  • Inhibitor Of Growth Family, Member 1-Like 2
  • Inhibitor Of Growth Protein 2 3

External Ids for ING2 Gene

Previous HGNC Symbols for ING2 Gene

  • ING1L

Previous GeneCards Identifiers for ING2 Gene

  • GC00U990666
  • GC0XM068188
  • GC0XM068944
  • GC0XM069578
  • GC0XM070494
  • GC04P184802
  • GC04P184663
  • GC04P184426
  • GC04P180185

Summaries for ING2 Gene

Entrez Gene Summary for ING2 Gene

  • This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for ING2 Gene

ING2 (Inhibitor Of Growth Family Member 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include chromatin binding and phosphatidylinositol binding. An important paralog of this gene is ING1.

UniProtKB/Swiss-Prot for ING2 Gene

  • Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Gene Wiki entry for ING2 Gene

Additional gene information for ING2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ING2 Gene

Genomics for ING2 Gene

GeneHancer (GH) Regulatory Elements for ING2 Gene

Promoters and enhancers for ING2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J183502 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 656.8 +1.1 1119 6.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ING2 LOC389247 TRAPPC11 CDKN2AIP RNU6-1053P STOX2 ENSG00000272744
GH04J183571 Enhancer 1 Ensembl ENCODE dbSUPER 11.8 +66.8 66847 1.3 PKNOX1 RFX1 ZEB2 ELF1 BMI1 E4F1 RFX5 CTBP1 RFX3 POLR2A LOC389247 ING2 LOC105377580 RNU6-479P
GH04J183587 Enhancer 0.8 ENCODE 11.3 +83.4 83392 1.5 PKNOX1 INSM2 FEZF1 YY1 ZNF335 ZNF213 ZNF366 CEBPB ZEB2 TSHZ1 ING2 LOC389247 TRAPPC11 RNU6-1053P LOC105377580 RNU6-479P
GH04J183468 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.9 -35.3 -35281 3 SOX13 ZNF211 FOXA2 SAP130 MAX CEBPG RAD21 YY1 ZNF316 NFE2 CDKN2AIP TRAPPC11 RWDD4 ING2 VTI1BP2
GH04J183602 Enhancer 0.5 dbSUPER 11.7 +97.7 97711 0.4 CTCF ATF1 ZNF547 SMC3 REST RAD21 CREM ING2 LOC389247 RWDD4 TRAPPC11 RNU6-1053P LOC105377580 RNU6-479P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ING2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ING2 gene promoter:
  • p300
  • Spz1
  • STAT5B
  • HSF2
  • Sp1
  • ARP-1
  • FAC1
  • Nkx6-1
  • TBP

Genomic Locations for ING2 Gene

Genomic Locations for ING2 Gene
7,435 bases
Plus strand
6,103 bases
Plus strand

Genomic View for ING2 Gene

Genes around ING2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING2 Gene

Proteins for ING2 Gene

  • Protein details for ING2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inhibitor of growth protein 2
    Protein Accession:
    Secondary Accessions:
    • B6ZDS1
    • O95698

    Protein attributes for ING2 Gene

    280 amino acids
    Molecular mass:
    32808 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2.

    Alternative splice isoforms for ING2 Gene


neXtProt entry for ING2 Gene

Post-translational modifications for ING2 Gene

  • Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ING2 Gene

No data available for DME Specific Peptides for ING2 Gene

Domains & Families for ING2 Gene

Gene Families for ING2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ING2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING2: view

Function for ING2 Gene

Molecular function for ING2 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
UniProtKB/Swiss-Prot Induction:
Induced by the DNA-damaging agents etoposide and neocarzinostatin.

Gene Ontology (GO) - Molecular Function for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15243141
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18334480
GO:0035064 methylated histone binding IDA 16728974
GO:0035091 phosphatidylinositol binding IDA 16893883
genes like me logo Genes that share ontologies with ING2: view
genes like me logo Genes that share phenotypes with ING2: view

Animal Models for ING2 Gene

MGI Knock Outs for ING2:
  • Ing2 Ing2<tm1.1Ccha>

Animal Model Products

miRNA for ING2 Gene

miRTarBase miRNAs that target ING2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ING2 Gene

Localization for ING2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING2 Gene

Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP,IEA 25578879
GO:0005654 nucleoplasm IDA,TAS --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IMP 25578879
genes like me logo Genes that share ontologies with ING2: view

Pathways & Interactions for ING2 Gene

genes like me logo Genes that share pathways with ING2: view

Gene Ontology (GO) - Biological Process for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 15243141
GO:0007141 male meiosis I ISS 21124965
GO:0007165 signal transduction TAS 10072587
genes like me logo Genes that share ontologies with ING2: view

No data available for SIGNOR curated interactions for ING2 Gene

Drugs & Compounds for ING2 Gene

No Compound Related Data Available

Transcripts for ING2 Gene

mRNA/cDNA for ING2 Gene

Unigene Clusters for ING2 Gene

Inhibitor of growth family, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ING2 Gene

No ASD Table

Relevant External Links for ING2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ING2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ING2 Gene

Protein differential expression in normal tissues from HIPED for ING2 Gene

This gene is overexpressed in Cervix (51.5) and Plasma (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ING2 Gene

Protein tissue co-expression partners for ING2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ING2 Gene:


SOURCE GeneReport for Unigene cluster for ING2 Gene:


mRNA Expression by UniProt/SwissProt for ING2 Gene:

Tissue specificity: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.

Evidence on tissue expression from TISSUES for ING2 Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with ING2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING2 Gene

Orthologs for ING2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ING2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ING2 34 33
  • 99.88 (n)
(Canis familiaris)
Mammalia ING2 34 33
  • 94.88 (n)
(Bos Taurus)
Mammalia ING2 34 33
  • 91.55 (n)
(Rattus norvegicus)
Mammalia Ing2 33
  • 91.4 (n)
(Mus musculus)
Mammalia Ing2 16 34 33
  • 90.6 (n)
(Monodelphis domestica)
Mammalia ING2 34
  • 86 (a)
(Gallus gallus)
Aves ING2 34 33
  • 75.55 (n)
(Anolis carolinensis)
Reptilia ING2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ing2 33
  • 71.68 (n)
Str.6306 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398266 33
(Danio rerio)
Actinopterygii ing2 34 33
  • 67.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7379 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10422 34
  • 30 (a)
Species where no ortholog for ING2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING2 Gene

Gene Tree for ING2 (if available)
Gene Tree for ING2 (if available)
Evolutionary constrained regions (ECRs) for ING2: view image

Paralogs for ING2 Gene

Paralogs for ING2 Gene

(4) SIMAP similar genes for ING2 Gene using alignment to 3 proteins:

  • C9J4X5_HUMAN
genes like me logo Genes that share paralogs with ING2: view

Variants for ING2 Gene

Sequence variations from dbSNP and Humsavar for ING2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000190736 -- 183,512,641(+) T/A/G downstream_transcript_variant
rs1000251885 -- 183,505,941(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001017642 -- 183,506,923(+) C/G 5_prime_UTR_variant, intron_variant
rs10013043 -- 183,510,140(+) A/C intron_variant
rs1001470999 -- 183,507,598(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ING2 Gene

Variant ID Type Subtype PubMed ID
nsv1030766 CNV gain 25217958
nsv822873 CNV gain 20364138
nsv830165 CNV loss 17160897

Variation tolerance for ING2 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ING2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING2 Gene

Disorders for ING2 Gene

Additional Disease Information for ING2

No disorders were found for ING2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ING2 Gene

Publications for ING2 Gene

  1. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. (PMID: 10072587) Shimada Y … Horie M (Cytogenetics and cell genetics 1998) 2 3 4 22 58
  2. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. (PMID: 12859901) Gozani O … Yuan J (Cell 2003) 3 4 22 58
  3. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PMID: 11481424) Nagashima M … Harris CC (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 58
  4. Sumoylation of ING2 regulates the transcription mediated by Sin3A. (PMID: 20676127) Ythier D … Pedeux R (Oncogene 2010) 3 4 58
  5. ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. (PMID: 19437536) Kumamoto K … Harris CC (International journal of cancer 2009) 3 22 58

Products for ING2 Gene

Sources for ING2 Gene

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