Aliases for CDKL4 Gene

Aliases for CDKL4 Gene

  • Cyclin Dependent Kinase Like 4 2 3 5
  • Cyclin-Dependent Kinase-Like 4 2 3 4
  • EC 4 52
  • EC 2.7.11 52

External Ids for CDKL4 Gene

Previous GeneCards Identifiers for CDKL4 Gene

  • GC02M039381
  • GC02M039317
  • GC02M039260
  • GC02M039402
  • GC02M039145

Summaries for CDKL4 Gene

GeneCards Summary for CDKL4 Gene

CDKL4 (Cyclin Dependent Kinase Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL1.

Additional gene information for CDKL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CDKL4 Gene

Genomics for CDKL4 Gene

GeneHancer (GH) Regulatory Elements for CDKL4 Gene

Promoters and enhancers for CDKL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J039243 Promoter 0.6 EPDnew 500.7 +2.7 2745 0.1 MXI1 POLR2G ZBTB33 AGO2 RBM22 SIN3A CDKL4 piR-33422-219 piR-31470-275 piR-58297-250 RF00017-3168
GH02J039244 Enhancer 0.4 ENCODE 500.7 +1.5 1528 0.7 POLR2A RBM22 ZBTB33 SCRT2 CDKL4 piR-33422-219 piR-31470-275 lnc-MAP4K3-1 piR-58297-250
GH02J038664 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +580.0 580027 3.6 FOXK2 ZNF217 SIN3A POLR2G NCOR1 GTF2E2 SIX5 KDM6A ZBTB11 TRIM28 GALM SRSF7 ENSG00000273035 MAP4K3 CDKL4 HNRNPLL ATL2 ENSG00000232518
GH02J039093 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +144.3 144309 19.4 EP300 ATF2 MXI1 OSR2 TCF12 NFIC ZBTB17 GATA3 CEBPG IRF1 SOS1 CDKL4 SRSF7 ENSG00000202309 THUMPD2 DHX57 MORN2 ARHGEF33 MAP4K3-DT HSPE1P13
GH02J039114 Enhancer 0.6 dbSUPER 11.3 +130.9 130897 2 ZNF316 NFIC NFE2 FOXA1 ZNF146 MAFG ATF2 ZMYM3 HSF1 ZNF770 CDKL4 DHX57 SOS1 L13714-265
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDKL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CDKL4

Top Transcription factor binding sites by QIAGEN in the CDKL4 gene promoter:
  • FOXD3
  • FOXI1
  • HFH-3
  • HSF1 (long)
  • HSF1short
  • IRF-7A
  • Nkx6-1
  • RORalpha1
  • STAT1

Genomic Locations for CDKL4 Gene

Genomic Locations for CDKL4 Gene
71,874 bases
Minus strand
53,943 bases
Minus strand

Genomic View for CDKL4 Gene

Genes around CDKL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDKL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDKL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL4 Gene

Proteins for CDKL4 Gene

  • Protein details for CDKL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase-like 4
    Protein Accession:
    Secondary Accessions:
    • Q2NME9

    Protein attributes for CDKL4 Gene

    379 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDKL4 Gene


neXtProt entry for CDKL4 Gene

Selected DME Specific Peptides for CDKL4 Gene


Post-translational modifications for CDKL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDKL4 Gene

Gene Families for CDKL4 Gene

Protein Domains for CDKL4 Gene

Suggested Antigen Peptide Sequences for CDKL4 Gene

GenScript: Design optimal peptide antigens:
  • Cyclin-dependent kinase-like 4 (CDKL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL4: view

Function for CDKL4 Gene

Molecular function for CDKL4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;.

Enzyme Numbers (IUBMB) for CDKL4 Gene

Phenotypes From GWAS Catalog for CDKL4 Gene

Gene Ontology (GO) - Molecular Function for CDKL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CDKL4: view
genes like me logo Genes that share phenotypes with CDKL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDKL4

Clone Products

  • Addgene plasmids for CDKL4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDKL4 Gene

Localization for CDKL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDKL4 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
mitochondrion 1
cytosol 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for CDKL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDKL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CDKL4 Gene

Pathways & Interactions for CDKL4 Gene

PathCards logo

SuperPathways for CDKL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDKL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA,IEA 21873635
GO:0016310 phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDKL4: view

No data available for Pathways by source and SIGNOR curated interactions for CDKL4 Gene

Drugs & Compounds for CDKL4 Gene

(1) Drugs for CDKL4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for CDKL4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CDKL4: view

Transcripts for CDKL4 Gene

mRNA/cDNA for CDKL4 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for CDKL4

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL4 Gene

No ASD Table

Relevant External Links for CDKL4 Gene

GeneLoc Exon Structure for

Expression for CDKL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDKL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDKL4 Gene

This gene is overexpressed in Testis (x14.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CDKL4

SOURCE GeneReport for Unigene cluster for CDKL4 Gene:

genes like me logo Genes that share expression patterns with CDKL4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDKL4 Gene

Orthologs for CDKL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDKL4 31 30
  • 98.4 (n)
(Bos Taurus)
Mammalia CDKL4 31 30
  • 92.7 (n)
(Canis familiaris)
Mammalia CDKL4 31 30
  • 92.12 (n)
(Rattus norvegicus)
Mammalia Cdkl4 30
  • 83.08 (n)
(Mus musculus)
Mammalia Cdkl4 17 31 30
  • 83.07 (n)
(Monodelphis domestica)
Mammalia CDKL4 31
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CDKL4 31
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7236 31
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y42A5A.4 31
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 65 (a)
Species where no ortholog for CDKL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDKL4 Gene

Gene Tree for CDKL4 (if available)
Gene Tree for CDKL4 (if available)
Evolutionary constrained regions (ECRs) for CDKL4: view image

Paralogs for CDKL4 Gene

genes like me logo Genes that share paralogs with CDKL4: view

Variants for CDKL4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CDKL4 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs34819676 - p.Ser288Tyr
rs35454041 - p.Arg53His
rs35947084 - p.Ser38Pro
rs56330730 - p.Arg307Cys
rs56353587 - p.Phe228Cys

Additional dbSNP identifiers (rs#s) for CDKL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for CDKL4 Gene

Variant ID Type Subtype PubMed ID
dgv6792n54 CNV gain 21841781
esv1085195 CNV deletion 17803354
esv2666347 CNV deletion 23128226
esv2677029 CNV deletion 23128226
esv2719953 CNV deletion 23290073
esv3590428 CNV loss 21293372
esv3590429 CNV loss 21293372
esv3590430 CNV loss 21293372
nsv1000658 CNV gain 25217958
nsv1127722 CNV deletion 24896259
nsv581495 CNV gain 21841781
nsv833847 CNV loss 17160897

Variation tolerance for CDKL4 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDKL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL4 Gene

Disorders for CDKL4 Gene

Additional Disease Information for CDKL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CDKL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDKL4 Gene

Publications for CDKL4 Gene

  1. Novel mutations in the CDKL5 gene, predicted effects and associated phenotypes. (PMID: 19241098) Russo S … Larizza L (Neurogenetics 2009) 3 41 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for CDKL4 Gene

  • Boster Bio Antibodies for CDKL4
  • Boster Bio ELISA Kits for CDKL4

Sources for CDKL4 Gene