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Aliases for IFNA5 Gene

Aliases for IFNA5 Gene

  • Interferon Alpha 5 2 3 5
  • Interferon Alpha-61 3 4
  • Interferon Alpha-G 3 4
  • IFN-Alpha-5 3 4
  • LeIF G 3 4
  • Interferon, Alpha 5 2
  • Interferon Alpha-5 3
  • IFN-AlphaG 3
  • INFA5 3
  • INA5 3

External Ids for IFNA5 Gene

Previous GeneCards Identifiers for IFNA5 Gene

  • GC09M021632
  • GC09M021505
  • GC09M021294

Summaries for IFNA5 Gene

GeneCards Summary for IFNA5 Gene

IFNA5 (Interferon Alpha 5) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway and Kaposi's sarcoma-associated herpesvirus infection. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA6.

UniProtKB/Swiss-Prot for IFNA5 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA5 Gene

Additional gene information for IFNA5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA5 Gene

Genomics for IFNA5 Gene

GeneHancer (GH) Regulatory Elements for IFNA5 Gene

Promoters and enhancers for IFNA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021305 Promoter 0.5 EPDnew 650.7 0.0 -28 0.1 IFNA5 IFNA20P
GH09J021334 Promoter/Enhancer 1.5 Ensembl ENCODE 11.1 -29.8 -29775 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 ELK1 KLHL9 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 IFNA20P
GH09J021268 Enhancer 0.5 Ensembl 11.5 +37.1 37112 0.4 IKZF1 EBF1 BMI1 MEF2B DPF2 IKZF2 SPI1 IFNA5 IFNA12P IFNA8 IFNWP2 IFNA13 MIR31 IFNA22P IFNA14
GH09J021239 Promoter 0.5 EPDnew 11.3 +65.3 65288 0.1 IFNA14 IFNA5 IFNA13 IFNA22P
GH09J021228 Promoter 0.5 EPDnew 10.3 +77.1 77052 0.1 GC09P021226 IFNA17 IFNA12P IFNA8 IFNWP2 IFNA5 IFNA13 IFNA20P IFNWP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA5 gene promoter:
  • AML1a
  • SRY
  • C/EBPalpha

Genomic Locations for IFNA5 Gene

Genomic Locations for IFNA5 Gene
988 bases
Minus strand
700 bases
Minus strand

Genomic View for IFNA5 Gene

Genes around IFNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA5 Gene

Proteins for IFNA5 Gene

  • Protein details for IFNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-5
    Protein Accession:
    Secondary Accessions:
    • Q52LX3

    Protein attributes for IFNA5 Gene

    189 amino acids
    Molecular mass:
    21942 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA5 Gene

Post-translational modifications for IFNA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA5 Gene

Domains & Families for IFNA5 Gene

Gene Families for IFNA5 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA5: view

Function for IFNA5 Gene

Molecular function for IFNA5 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 5,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA5: view
genes like me logo Genes that share phenotypes with IFNA5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA5 Gene

Localization for IFNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA5 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA5 Gene

Pathways & Interactions for IFNA5 Gene

genes like me logo Genes that share pathways with IFNA5: view

Interacting Proteins for IFNA5 Gene

Gene Ontology (GO) - Biological Process for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA5: view

No data available for SIGNOR curated interactions for IFNA5 Gene

Drugs & Compounds for IFNA5 Gene

(1) Drugs for IFNA5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IFNA5: view

Transcripts for IFNA5 Gene

mRNA/cDNA for IFNA5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA5 Gene

Interferon, alpha 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA5 Gene

No ASD Table

Relevant External Links for IFNA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA5 Gene

Protein differential expression in normal tissues from HIPED for IFNA5 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNA5 Gene

Protein tissue co-expression partners for IFNA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA5 Gene:


SOURCE GeneReport for Unigene cluster for IFNA5 Gene:


Evidence on tissue expression from TISSUES for IFNA5 Gene

  • Spleen(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with IFNA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA5 Gene

Orthologs for IFNA5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA5 34 33
  • 98.94 (n)
(Bos Taurus)
Mammalia -- 34
  • 64 (a)
IFNAG 34 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
  • 62 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
  • 61 (a)
  • 61 (a)
(Mus musculus)
Mammalia Ifna13 34
  • 62 (a)
Ifna6 34
  • 61 (a)
Ifna5 34
  • 60 (a)
Ifna9 34
  • 60 (a)
Ifna1 34
  • 60 (a)
Ifna12 34
  • 60 (a)
Gm12597 34
  • 59 (a)
Gm13280 34
  • 59 (a)
Ifna14 34
  • 58 (a)
Ifna11 34
  • 58 (a)
Ifnab 34
  • 58 (a)
Ifna7 34
  • 57 (a)
Ifna2 34
  • 57 (a)
Ifna4 34
  • 56 (a)
Species where no ortholog for IFNA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA5 Gene

Gene Tree for IFNA5 (if available)
Gene Tree for IFNA5 (if available)
Evolutionary constrained regions (ECRs) for IFNA5: view image

Paralogs for IFNA5 Gene

(18) SIMAP similar genes for IFNA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA5: view

Variants for IFNA5 Gene

Sequence variations from dbSNP and Humsavar for IFNA5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000359945 -- 21,306,843(-) A/G upstream_transcript_variant
rs1000372993 -- 21,306,675(-) C/T upstream_transcript_variant
rs1000719546 -- 21,304,317(-) T/A downstream_transcript_variant
rs1001910319 -- 21,306,145(-) G/A/T upstream_transcript_variant
rs1001920143 -- 21,305,906(-) ATTAAAATT/ATT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA5 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
esv3619961 CNV loss 21293372
nsv438097 CNV loss 16468122
nsv613757 CNV loss 21841781
nsv968601 CNV duplication 23825009

Variation tolerance for IFNA5 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA5 Gene

Disorders for IFNA5 Gene

Additional Disease Information for IFNA5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFNA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA5 Gene

Publications for IFNA5 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  2. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  3. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 44 58

Products for IFNA5 Gene

Sources for IFNA5 Gene

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