Aliases for IDH3G Gene
- Isocitrate Dehydrogenase 3 (NAD(+)) Gamma 2 3 5
- Isocitrate Dehydrogenase 3 (NAD+) Gamma 2 3
- Isocitric Dehydrogenase Subunit Gamma 3 4
- NAD(+)-Specific ICDH Subunit Gamma 3 4
- Isocitrate Dehydrogenase, NAD(+)-Specific, Mitochondrial, Gamma Subunit 3
- Isocitrate Dehydrogenase [NAD] Subunit Gamma, Mitochondrial 3
External Ids for IDH3G Gene
Previous GeneCards Identifiers for IDH3G Gene
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for IDH3G Gene
IDH3G (Isocitrate Dehydrogenase 3 (NAD(+)) Gamma) is a Protein Coding gene. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). Gene Ontology (GO) annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3B.
UniProtKB/Swiss-Prot for IDH3G Gene
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.