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Aliases for IDH3G Gene

Aliases for IDH3G Gene

  • Isocitrate Dehydrogenase 3 (NAD(+)) Gamma 2 3 5
  • Isocitrate Dehydrogenase 3 (NAD+) Gamma 2 3
  • Isocitric Dehydrogenase Subunit Gamma 3 4
  • NAD(+)-Specific ICDH Subunit Gamma 3 4
  • Isocitrate Dehydrogenase, NAD(+)-Specific, Mitochondrial, Gamma Subunit 3
  • Isocitrate Dehydrogenase [NAD] Subunit Gamma, Mitochondrial 3
  • NAD (H)-Specific Isocitrate Dehydrogenase Gamma Subunit 3
  • Isocitrate Dehydrogenase 3 Gamma 3
  • NAD+-Specific ICDH 3
  • IDH-Gamma 3
  • H-IDHG 3

External Ids for IDH3G Gene

Previous GeneCards Identifiers for IDH3G Gene

  • GC0XM147188
  • GC0XM149506
  • GC0XM150636
  • GC0XM151519
  • GC0XM152572
  • GC0XM152704
  • GC0XM153051
  • GC0XM141708

Summaries for IDH3G Gene

Entrez Gene Summary for IDH3G Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3G Gene

IDH3G (Isocitrate Dehydrogenase 3 (NAD(+)) Gamma) is a Protein Coding gene. Among its related pathways are Metabolism and Citrate cycle (TCA cycle). Gene Ontology (GO) annotations related to this gene include magnesium ion binding and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is IDH3B.

UniProtKB/Swiss-Prot for IDH3G Gene

  • Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.

Gene Wiki entry for IDH3G Gene

Additional gene information for IDH3G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3G Gene

Genomics for IDH3G Gene

GeneHancer (GH) Regulatory Elements for IDH3G Gene

Promoters and enhancers for IDH3G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ153792 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.1 144 3.3 PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF143 FOS SP3 SSR4 IDH3G PLXNB3 SRPK3
GH0XJ153884 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 13.3 -91.6 -91582 3 CTCF KLF1 MAX KLF17 ZIC2 RAD21 HIC1 ZFHX2 GATA3 GLIS2 L1CAM RENBP TMEM187 HCFC1 SNORA70 PDZD4 SSR4 IDH3G SRPK3 PLXNB3
GH0XJ153844 Enhancer 0.6 ENCODE 13.7 -51.2 -51156 1.8 MEIS2 NANOG BACH1 MAFG SP1 ZNF316 ZNF143 MAFK EMSY IDH3G SSR4 SRPK3 PLXNB3 L1CAM ABCD1 BCAP31 FAM3A CYCSP45 GC0XM153869
GH0XJ153854 Enhancer 0.4 ENCODE 13.5 -60.3 -60338 0.2 CTCF HLF L1CAM PDZD4 AVPR2 IDH3G SSR4 SRPK3 PLXNB3 ABCD1 BCAP31 CYCSP45
GH0XJ153802 Enhancer 0.5 dbSUPER 5.6 -7.9 -7860 0.5 ZFHX2 CREB1 ZNF398 WT1 EGR2 IDH3G PDZD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IDH3G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IDH3G gene promoter:
  • FOXO1
  • FOXO1a
  • AP-1
  • NF-1
  • NF-1/L
  • ZIC2
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1

Genomic Locations for IDH3G Gene

Genomic Locations for IDH3G Gene
chrX:153,785,766-153,794,523
(GRCh38/hg38)
Size:
8,758 bases
Orientation:
Minus strand
chrX:153,051,221-153,059,978
(GRCh37/hg19)
Size:
8,758 bases
Orientation:
Minus strand

Genomic View for IDH3G Gene

Genes around IDH3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IDH3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IDH3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3G Gene

Proteins for IDH3G Gene

  • Protein details for IDH3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51553-IDH3G_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Protein Accession:
    P51553
    Secondary Accessions:
    • E9PDD5
    • Q9BUU5

    Protein attributes for IDH3G Gene

    Size:
    393 amino acids
    Molecular mass:
    42794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.

    Three dimensional structures from OCA and Proteopedia for IDH3G Gene

    Alternative splice isoforms for IDH3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3G Gene

Post-translational modifications for IDH3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IDH3G Gene

Domains & Families for IDH3G Gene

Gene Families for IDH3G Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IDH3G Gene

Graphical View of Domain Structure for InterPro Entry

P51553

UniProtKB/Swiss-Prot:

IDH3G_HUMAN :
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3G: view

Function for IDH3G Gene

Molecular function for IDH3G Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
UniProtKB/Swiss-Prot EnzymeRegulation:
The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.
GENATLAS Biochemistry:
isocitrate dehydrogenase 3,gamma subunit,NADH dependent,mitochondrial matrix,expressed in many tissues,catalyzing the third step of citric acid cycle,catalyzing the oxidative decarboxylation of isocitrate into alpha-ketoglutarate

Gene Ontology (GO) - Molecular Function for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA,IEA 28098230
GO:0004449 isocitrate dehydrogenase (NAD+) activity ISS,IEA --
GO:0005524 ATP binding IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IDH3G: view
genes like me logo Genes that share phenotypes with IDH3G: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IDH3G

CRISPR Products

miRNA for IDH3G Gene

miRTarBase miRNAs that target IDH3G

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3G

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IDH3G Gene

Localization for IDH3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3G Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IDH3G gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion ISS,IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with IDH3G: view

Pathways & Interactions for IDH3G Gene

genes like me logo Genes that share pathways with IDH3G: view

Gene Ontology (GO) - Biological Process for IDH3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 9286695
GO:0006099 tricarboxylic acid cycle TAS,IEA --
GO:0006102 isocitrate metabolic process ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with IDH3G: view

No data available for SIGNOR curated interactions for IDH3G Gene

Drugs & Compounds for IDH3G Gene

(7) Drugs for IDH3G Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra Target 37
NADH Approved Nutra Target 0
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Magnesium Approved Nutra 0
Isocitric acid Experimental Pharma 0

(1) Additional Compounds for IDH3G Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with IDH3G: view

Transcripts for IDH3G Gene

mRNA/cDNA for IDH3G Gene

Unigene Clusters for IDH3G Gene

Isocitrate dehydrogenase 3 (NAD+) gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IDH3G

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3G Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for IDH3G Gene

GeneLoc Exon Structure for
IDH3G
ECgene alternative splicing isoforms for
IDH3G

Expression for IDH3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IDH3G Gene

Protein differential expression in normal tissues from HIPED for IDH3G Gene

This gene is overexpressed in Brain (10.4), Heart (7.6), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IDH3G Gene



Protein tissue co-expression partners for IDH3G Gene

NURSA nuclear receptor signaling pathways regulating expression of IDH3G Gene:

IDH3G

SOURCE GeneReport for Unigene cluster for IDH3G Gene:

Hs.410197

Evidence on tissue expression from TISSUES for IDH3G Gene

  • Nervous system(4.8)
  • Heart(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with IDH3G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IDH3G Gene

Orthologs for IDH3G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDH3G 34 33
  • 91.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IDH3G 34 33
  • 90.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IDH3G 34 33
  • 90.73 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDH3G 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idh3g 16 34 33
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia Idh3g 33
  • 87.62 (n)
oppossum
(Monodelphis domestica)
Mammalia IDH3G 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves IDH3G 34
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IDH3G 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idh3g 33
  • 71.69 (n)
zebrafish
(Danio rerio)
Actinopterygii idh3g 34
  • 70 (a)
OneToOne
zgc:113076 33
  • 69.18 (n)
wufa01b02 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002192 33
  • 60.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5028 34 35 33
  • 58.88 (n)
OneToMany
CG6439 35
  • 51 (a)
CG7755 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F35G12.2 35
  • 57 (a)
idhg-1 34 33
  • 56.89 (n)
OneToMany
C30F12.7 35
  • 56 (a)
idhg-2 34
  • 53 (a)
OneToMany
C37E2.1 35
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH1 36 34
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons IDH-III 33
  • 49.56 (n)
soybean
(Glycine max)
eudicotyledons Gma.7096 33
barley
(Hordeum vulgare)
Liliopsida Hv.2555 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8404 34
  • 55 (a)
OneToOne
Species where no ortholog for IDH3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IDH3G Gene

ENSEMBL:
Gene Tree for IDH3G (if available)
TreeFam:
Gene Tree for IDH3G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IDH3G: view image

Paralogs for IDH3G Gene

Paralogs for IDH3G Gene

(3) SIMAP similar genes for IDH3G Gene using alignment to 8 proteins:

  • IDH3G_HUMAN
  • E7EQB8_HUMAN
  • E9PF84_HUMAN
  • G5E9Q7_HUMAN
  • H0Y5Q7_HUMAN
  • H7C1W2_HUMAN
  • Q2Q9C5_HUMAN
  • Q2Q9S4_HUMAN

Pseudogenes.org Pseudogenes for IDH3G Gene

genes like me logo Genes that share paralogs with IDH3G: view

Variants for IDH3G Gene

Sequence variations from dbSNP and Humsavar for IDH3G Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs139415367 likely-benign, not specified 153,796,486(-) C/T upstream_transcript_variant
rs374141854 likely-benign, not specified 153,794,653(-) G/A/T upstream_transcript_variant
rs782739266 uncertain-significance, not specified 153,796,508(-) G/A upstream_transcript_variant
rs1000061564 -- 153,786,012(-) G/A 3_prime_UTR_variant, intron_variant
rs1000114958 -- 153,785,760(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IDH3G Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407

Variation tolerance for IDH3G Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IDH3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IDH3G

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IDH3G Gene

Disorders for IDH3G Gene

Additional Disease Information for IDH3G

No disorders were found for IDH3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IDH3G Gene

Publications for IDH3G Gene

  1. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PMID: 9286695) Brenner V … Platzer M (Genomics 1997) 2 3 4 58
  2. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. (PMID: 28098230) Ma T … Ding J (Scientific reports 2017) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson JC … Wiemann S (EMBO reports 2000) 3 4 58
  5. Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform. (PMID: 10601238) Kim YO … Huh TL (The Journal of biological chemistry 1999) 3 4 58

Products for IDH3G Gene

Sources for IDH3G Gene

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