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Aliases for MYLK4 Gene

Aliases for MYLK4 Gene

  • Myosin Light Chain Kinase Family Member 4 2 3 3 5
  • Sugen Kinase 85 3 4
  • CaMLCK Like 2 3
  • SgK085 3 4
  • Myosin Light Chain Kinase Family, Member 4 2
  • EC 2.7.11.1 4
  • SGK085 4

External Ids for MYLK4 Gene

Previous GeneCards Identifiers for MYLK4 Gene

  • GC06M002613

Summaries for MYLK4 Gene

GeneCards Summary for MYLK4 Gene

MYLK4 (Myosin Light Chain Kinase Family Member 4) is a Protein Coding gene. Among its related pathways are Apelin signaling pathway and Salivary secretion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYLK3.

Tocris Summary for MYLK4 Gene

  • Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that are currently divided into two subtypes. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19. MLCK2 is located in the striated muscle.

Additional gene information for MYLK4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYLK4 Gene

Genomics for MYLK4 Gene

GeneHancer (GH) Regulatory Elements for MYLK4 Gene

Promoters and enhancers for MYLK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J002769 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.2 -183 0.7 HDGF HDAC1 SMAD1 NFIB KLF17 KLF14 NCOA2 SCRT2 ZBTB2 ZNF491 GC06P002769 MYLK4 LINC01011 SERPINB9 ENSG00000232999 WRNIP1 GC06P002811
GH06J002750 Promoter/Enhancer 0.9 EPDnew dbSUPER 650.4 +19.2 19183 0.1 BCOR ZMYM3 KDM1A MYLK4 GC06M002701 GC06P002738
GH06J002770 Enhancer 0.6 ENCODE dbSUPER 650.7 -1.2 -1163 0.6 ZBTB6 FEZF1 ZNF600 GC06P002769 MYLK4 SERPINB9 ENSG00000232999 WRNIP1 GC06P002811
GH06J002732 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +36.6 36608 1.8 HDAC1 ATF1 NFRKB SIN3A ZNF766 ATF7 IKZF2 RUNX3 CREM CBFB GC06P002732 MYLK4 SERPINB9 WRNIP1 PSMG4 SERPINB1 NQO2 RIPK1 GC06P002738 GC06M002701
GH06J002725 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +43.5 43528 1.7 YBX3 ARNT NFRKB ZNF766 ZNF366 SIRT6 ETV6 RUNX3 SMARCA5 GATAD2B MYLK4 WRNIP1 SERPINB9 SERPINB1 RIPK1 NQO2 GC06P002732 GC06P002711 GC06M002701
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYLK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYLK4 gene promoter:
  • aMEF-2
  • ATF
  • MEF-2A
  • HNF-4alpha1
  • HNF-4alpha2
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1

Genomic Locations for MYLK4 Gene

Genomic Locations for MYLK4 Gene
chr6:2,663,629-2,770,123
(GRCh38/hg38)
Size:
106,495 bases
Orientation:
Minus strand
chr6:2,663,863-2,751,200
(GRCh37/hg19)
Size:
87,338 bases
Orientation:
Minus strand

Genomic View for MYLK4 Gene

Genes around MYLK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYLK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYLK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYLK4 Gene

Proteins for MYLK4 Gene

  • Protein details for MYLK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YV6-MYLK4_HUMAN
    Recommended name:
    Myosin light chain kinase family member 4
    Protein Accession:
    Q86YV6
    Secondary Accessions:
    • A2RUC0
    • Q5TAW2

    Protein attributes for MYLK4 Gene

    Size:
    388 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYLK4 Gene

    Alternative splice isoforms for MYLK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYLK4 Gene

Post-translational modifications for MYLK4 Gene

No Post-translational modifications

Other Protein References for MYLK4 Gene

No data available for DME Specific Peptides for MYLK4 Gene

Domains & Families for MYLK4 Gene

Gene Families for MYLK4 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for MYLK4 Gene

Suggested Antigen Peptide Sequences for MYLK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YV6

UniProtKB/Swiss-Prot:

MYLK4_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MYLK4: view

Function for MYLK4 Gene

Molecular function for MYLK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MYLK4 Gene

Phenotypes From GWAS Catalog for MYLK4 Gene

Gene Ontology (GO) - Molecular Function for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004687 myosin light chain kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with MYLK4: view
genes like me logo Genes that share phenotypes with MYLK4: view

Animal Model Products

Clone Products

  • Addgene plasmids for MYLK4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYLK4 Gene

Localization for MYLK4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYLK4 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with MYLK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MYLK4 Gene

Pathways & Interactions for MYLK4 Gene

genes like me logo Genes that share pathways with MYLK4: view

Gene Ontology (GO) - Biological Process for MYLK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with MYLK4: view

No data available for SIGNOR curated interactions for MYLK4 Gene

Drugs & Compounds for MYLK4 Gene

(4) Drugs for MYLK4 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
ML 9 hydrochloride Pharma Myosin light chain kinase inhibitor 0
MLCK inhibitor peptide 18 Pharma Selective inhibitor of myosin light chain kinase 0

(1) Additional Compounds for MYLK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(2) Tocris Compounds for MYLK4 Gene

Compound Action Cas Number
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
MLCK inhibitor peptide 18 Selective inhibitor of myosin light chain kinase 224579-74-2
genes like me logo Genes that share compounds with MYLK4: view

Transcripts for MYLK4 Gene

mRNA/cDNA for MYLK4 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYLK4 Gene

Myosin light chain kinase family, member 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for MYLK4

Alternative Splicing Database (ASD) splice patterns (SP) for MYLK4 Gene

No ASD Table

Relevant External Links for MYLK4 Gene

GeneLoc Exon Structure for
MYLK4
ECgene alternative splicing isoforms for
MYLK4

Expression for MYLK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYLK4 Gene

mRNA differential expression in normal tissues according to GTEx for MYLK4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.5).

Protein differential expression in normal tissues from HIPED for MYLK4 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYLK4 Gene



Protein tissue co-expression partners for MYLK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYLK4 Gene:

MYLK4

SOURCE GeneReport for Unigene cluster for MYLK4 Gene:

Hs.127830

Evidence on tissue expression from TISSUES for MYLK4 Gene

  • Spleen(4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MYLK4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYLK4 Gene

Orthologs for MYLK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYLK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYLK4 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYLK4 34 33
  • 88.54 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYLK4 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mylk4 33
  • 84.89 (n)
cow
(Bos Taurus)
Mammalia MYLK4 34 33
  • 84.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mylk4 16 34 33
  • 84.08 (n)
oppossum
(Monodelphis domestica)
Mammalia MYLK4 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYLK4 34 33
  • 77.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYLK4 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497991 33
  • 70.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2372 33
zebrafish
(Danio rerio)
Actinopterygii LOC566845 33
  • 70.92 (n)
mylk4b 34
  • 32 (a)
OneToMany
mylk4a 34
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sqa 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC373.4 34
  • 12 (a)
OneToMany
Species where no ortholog for MYLK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYLK4 Gene

ENSEMBL:
Gene Tree for MYLK4 (if available)
TreeFam:
Gene Tree for MYLK4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYLK4: view image

Paralogs for MYLK4 Gene

Paralogs for MYLK4 Gene

genes like me logo Genes that share paralogs with MYLK4: view

Variants for MYLK4 Gene

Sequence variations from dbSNP and Humsavar for MYLK4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs762093504 A breast infiltrating ductal carcinoma sample 2,692,787(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs796052168 likely-benign, Long QT syndrome 2,685,390(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_040864 A breast infiltrating ductal carcinoma sample p.Glu30Gln
VAR_040868 A lung squamous cell carcinoma sample p.His217Leu
rs1000002472 -- 2,753,577(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYLK4 Gene

Variant ID Type Subtype PubMed ID
esv1778065 CNV insertion 17803354
esv2434989 CNV insertion 19546169
esv2731465 CNV deletion 23290073
esv2731466 CNV deletion 23290073
esv274995 CNV loss 21479260
esv3570726 CNV loss 25503493
esv3570727 CNV loss 25503493
esv3570728 CNV loss 25503493
esv3570729 CNV loss 25503493
esv3607900 CNV gain 21293372
esv3607912 CNV gain 21293372
nsv1131934 CNV deletion 24896259
nsv474757 CNV novel sequence insertion 20440878
nsv521426 CNV loss 19592680
nsv830574 CNV gain 17160897

Variation tolerance for MYLK4 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYLK4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYLK4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYLK4 Gene

Disorders for MYLK4 Gene

Additional Disease Information for MYLK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MYLK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYLK4 Gene

Publications for MYLK4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MYLK4 Gene

Sources for MYLK4 Gene

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