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Aliases for ST8SIA6 Gene

Aliases for ST8SIA6 Gene

  • ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6 2 3 5
  • SIAT8F 2 3 4
  • Sialyltransferase St8Sia VI 3 4
  • ST8SiaVI 3 4
  • SIAT8-F 3 4
  • ST8 Alpha-N-Acetylneuraminate Alpha-2,8-Sialyltransferase 6 3
  • Sialyltransferase 8F (Alpha-2, 8-Sialyltransferase) 3
  • Alpha-2,8-Sialyltransferase 8F 3
  • Sialyltransferase 8F 4
  • EC 2.4.99.- 4
  • ST8SIA-VI 3
  • ST8Sia VI 2
  • SIA8F 3

External Ids for ST8SIA6 Gene

Previous HGNC Symbols for ST8SIA6 Gene

  • SIAT8F

Previous GeneCards Identifiers for ST8SIA6 Gene

  • GC10M017403
  • GC10M017276

Summaries for ST8SIA6 Gene

Entrez Gene Summary for ST8SIA6 Gene

  • This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for ST8SIA6 Gene

ST8SIA6 (ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6) is a Protein Coding gene. Diseases associated with ST8SIA6 include Lice Infestation. Among its related pathways are N-glycan antennae elongation in the medial/trans-Golgi and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sialyltransferase activity. An important paralog of this gene is ST8SIA5.

UniProtKB/Swiss-Prot for ST8SIA6 Gene

  • Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).

Additional gene information for ST8SIA6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ST8SIA6 Gene

Genomics for ST8SIA6 Gene

GeneHancer (GH) Regulatory Elements for ST8SIA6 Gene

Promoters and enhancers for ST8SIA6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J017451 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 658.6 +2.0 1995 4.7 HDGF PKNOX1 SMAD1 ATF1 ARNT SIN3A ZNF2 POLR2B GLIS2 ARID2 ST8SIA6 HACD1 LOC105376436
GH10J017456 Enhancer 0.7 dbSUPER 650.7 -1.8 -1776 1 MEIS2 LEF1 ARNT TEAD4 TAL1 TCF12 CC2D1A ZNF766 NCOR1 STAT2 ST8SIA6 HACD1 LOC105376437
GH10J017423 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +28.8 28802 6.2 HDGF PKNOX1 SMAD1 ARNT YBX1 POLR2B ZNF766 E2F8 ZNF592 MEF2D LOC105376438 ST8SIA6 TMEM236 ST8SIA6-AS1 STAM TRDMT1 LOC105376436 ENSG00000251803
GH10J017504 Enhancer 1 FANTOM5 ENCODE 18.3 -50.8 -50821 3.9 HDGF GTF2F1 IRF2 E4F1 ZNF316 SCRT2 MAFK KDM4B GATAD2A SCRT1 ST8SIA6 HACD1 STAM LOC105376438 GC10M017482 PRPF38AP2
GH10J017508 Enhancer 1.2 Ensembl ENCODE 11.8 -55.9 -55909 5.2 HDGF PKNOX1 SMAD1 ARNT IRF4 GTF3C2 TCF12 ZNF121 GATA2 FOS ST8SIA6 HACD1 LOC105376438 GC10M017482 PRPF38AP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ST8SIA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ST8SIA6 gene promoter:
  • RFX1
  • CUTL1
  • FOXO1a
  • FOXO1
  • CBF(2)
  • NF-Y
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • Pax-5

Genomic Locations for ST8SIA6 Gene

Genomic Locations for ST8SIA6 Gene
140,097 bases
Minus strand
135,948 bases
Minus strand

Genomic View for ST8SIA6 Gene

Genes around ST8SIA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ST8SIA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ST8SIA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ST8SIA6 Gene

Proteins for ST8SIA6 Gene

  • Protein details for ST8SIA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-2,8-sialyltransferase 8F
    Protein Accession:
    Secondary Accessions:
    • B0YJ97
    • B9EH72
    • Q5VZH4

    Protein attributes for ST8SIA6 Gene

    398 amino acids
    Molecular mass:
    44836 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ST8SIA6 Gene

Post-translational modifications for ST8SIA6 Gene

  • Glycosylation at posLast=196196, posLast=151151, posLast=9393, and isoforms=66
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for ST8SIA6

No data available for DME Specific Peptides for ST8SIA6 Gene

Domains & Families for ST8SIA6 Gene

Gene Families for ST8SIA6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ST8SIA6 Gene

Suggested Antigen Peptide Sequences for ST8SIA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 29 family.
  • Belongs to the glycosyltransferase 29 family.
genes like me logo Genes that share domains with ST8SIA6: view

Function for ST8SIA6 Gene

Molecular function for ST8SIA6 Gene

UniProtKB/Swiss-Prot Function:
Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).

Enzyme Numbers (IUBMB) for ST8SIA6 Gene

Phenotypes From GWAS Catalog for ST8SIA6 Gene

Gene Ontology (GO) - Molecular Function for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS --
GO:0008373 sialyltransferase activity ISS 11980897
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ST8SIA6: view
genes like me logo Genes that share phenotypes with ST8SIA6: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ST8SIA6 Gene

Localization for ST8SIA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ST8SIA6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ST8SIA6 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ST8SIA6: view

Pathways & Interactions for ST8SIA6 Gene

genes like me logo Genes that share pathways with ST8SIA6: view

UniProtKB/Swiss-Prot P61647-SIA8F_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for ST8SIA6 Gene

Gene Ontology (GO) - Biological Process for ST8SIA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001574 ganglioside biosynthetic process ISS,IEA 11980897
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation ISS 11980897
GO:0009100 glycoprotein metabolic process IEA,ISS 11980897
GO:0009247 glycolipid biosynthetic process ISS 11980897
genes like me logo Genes that share ontologies with ST8SIA6: view

No data available for SIGNOR curated interactions for ST8SIA6 Gene

Drugs & Compounds for ST8SIA6 Gene

No Compound Related Data Available

Transcripts for ST8SIA6 Gene

mRNA/cDNA for ST8SIA6 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ST8SIA6 Gene

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ST8SIA6 Gene

No ASD Table

Relevant External Links for ST8SIA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ST8SIA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ST8SIA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ST8SIA6 Gene:


SOURCE GeneReport for Unigene cluster for ST8SIA6 Gene:

genes like me logo Genes that share expression patterns with ST8SIA6: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ST8SIA6 Gene

Orthologs for ST8SIA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ST8SIA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ST8SIA6 34 33
  • 99.41 (n)
(Canis familiaris)
Mammalia ST8SIA6 34 33
  • 85.34 (n)
(Mus musculus)
Mammalia St8sia6 16 34 33
  • 82.33 (n)
(Rattus norvegicus)
Mammalia St8sia6 33
  • 81.32 (n)
(Bos Taurus)
Mammalia ST8SIA6 34
  • 78 (a)
(Monodelphis domestica)
Mammalia ST8SIA6 34
  • 59 (a)
(Gallus gallus)
Aves ST8SIA6 34 33
  • 68.9 (n)
(Anolis carolinensis)
Reptilia ST8SIA6 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia st8sia6 33
  • 64.13 (n)
(Danio rerio)
Actinopterygii st8sia6 34 33
  • 53.99 (n)
Species where no ortholog for ST8SIA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ST8SIA6 Gene

Gene Tree for ST8SIA6 (if available)
Gene Tree for ST8SIA6 (if available)
Evolutionary constrained regions (ECRs) for ST8SIA6: view image

Paralogs for ST8SIA6 Gene

Paralogs for ST8SIA6 Gene

(7) SIMAP similar genes for ST8SIA6 Gene using alignment to 2 proteins:

  • H0Y405_HUMAN
genes like me logo Genes that share paralogs with ST8SIA6: view

Variants for ST8SIA6 Gene

Sequence variations from dbSNP and Humsavar for ST8SIA6 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs193920832 uncertain-significance, Malignant tumor of prostate 17,359,547(-) C/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000023944 -- 17,434,666(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000035308 -- 17,341,590(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000038980 -- 17,358,819(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000069208 -- 17,357,365(-) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ST8SIA6 Gene

Variant ID Type Subtype PubMed ID
esv2027380 CNV deletion 18987734
esv2658114 CNV deletion 23128226
esv2733639 CNV deletion 23290073
esv2733650 CNV deletion 23290073
esv3407759 CNV insertion 20981092
esv3576094 CNV gain 25503493
esv3578664 CNV loss 25503493
esv3622484 CNV gain 21293372
esv3622485 CNV loss 21293372
esv3891766 CNV loss 25118596
nsv1039697 CNV loss 25217958
nsv1046522 CNV loss 25217958
nsv1068286 CNV deletion 25765185
nsv1069028 CNV deletion 25765185
nsv1116633 CNV tandem duplication 24896259
nsv1127090 CNV deletion 24896259
nsv24310 CNV deletion 16902084
nsv474853 CNV novel sequence insertion 20440878
nsv5954 CNV deletion 18451855
nsv5966 CNV insertion 18451855

Variation tolerance for ST8SIA6 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ST8SIA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ST8SIA6 Gene

Disorders for ST8SIA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ST8SIA6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lice infestation
  • infestation by pediculus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ST8SIA6

genes like me logo Genes that share disorders with ST8SIA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ST8SIA6 Gene

Publications for ST8SIA6 Gene

  1. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PMID: 19176441) Yang JJ … Relling MV (JAMA 2009) 3 44 58
  2. Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression. (PMID: 16857734) Avril T … Crocker PR (Journal of leukocyte biology 2006) 3 22 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. Molecular cloning and expression of a sixth type of alpha 2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans. (PMID: 11980897) Takashima S … Tsujimoto M (The Journal of biological chemistry 2002) 2 3 58
  5. Upregulation of Human ST8Sia VI (α2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells. (PMID: 27490539) Yoon HK … Lee YC (International journal of molecular sciences 2016) 3 58

Products for ST8SIA6 Gene

Sources for ST8SIA6 Gene

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