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Aliases for RAB7B Gene

Aliases for RAB7B Gene

  • RAB7B, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-7b 3
  • Ras-Related Protein Rab-7 3
  • RAB7 3

External Ids for RAB7B Gene

Previous GeneCards Identifiers for RAB7B Gene

  • GC01U901021
  • GC00P1O0000

Summaries for RAB7B Gene

GeneCards Summary for RAB7B Gene

RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Phagosome and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB7A.

UniProtKB/Swiss-Prot for RAB7B Gene

  • Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Gene Wiki entry for RAB7B Gene

Additional gene information for RAB7B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB7B Gene

Genomics for RAB7B Gene

GeneHancer (GH) Regulatory Elements for RAB7B Gene

Promoters and enhancers for RAB7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206003 Promoter 0.5 Ensembl 650.7 +0.2 194 0.2 RAB7B LOC103021295
GH01J206020 Promoter/Enhancer 1.1 EPDnew ENCODE 0.4 -19.0 -18952 4.1 RXRA JUN TEAD4 TAL1 CBFA2T3 ZNF395 TCF12 HNF4G CBFA2T2 HNF4A CTSE PM20D1 RAB7B
GH01J206011 Enhancer 1 Ensembl ENCODE 0.4 -8.9 -8875 1.4 HDGF HDAC1 PKNOX1 RB1 BMI1 IRF4 ZNF143 ATF7 IKZF2 EGR2 RAB7B CTSE
GH01J205999 Enhancer 0.2 Ensembl 0.7 +3.7 3694 0.4 RAB7B LOC103021295
GH01J206013 Enhancer 0.2 ENCODE 0.4 -10.1 -10098 0.2 CTSE RAB7B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB7B on UCSC Golden Path with GeneCards custom track

Genomic Locations for RAB7B Gene

Genomic Locations for RAB7B Gene
chr1:205,976,740-206,003,495
(GRCh38/hg38)
Size:
26,756 bases
Orientation:
Minus strand

Genomic View for RAB7B Gene

Genes around RAB7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB7B Gene

Proteins for RAB7B Gene

  • Protein details for RAB7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AH8-RAB7B_HUMAN
    Recommended name:
    Ras-related protein Rab-7b
    Protein Accession:
    Q96AH8

    Protein attributes for RAB7B Gene

    Size:
    199 amino acids
    Molecular mass:
    22511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB7B Gene

Post-translational modifications for RAB7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB7B Gene

Domains & Families for RAB7B Gene

Gene Families for RAB7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB7B Gene

Suggested Antigen Peptide Sequences for RAB7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AH8

UniProtKB/Swiss-Prot:

RAB7B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB7B: view

Function for RAB7B Gene

Molecular function for RAB7B Gene

UniProtKB/Swiss-Prot Function:
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Gene Ontology (GO) - Molecular Function for RAB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB7B: view
genes like me logo Genes that share phenotypes with RAB7B: view

Animal Model Products

miRNA for RAB7B Gene

miRTarBase miRNAs that target RAB7B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB7B Gene

Localization for RAB7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB7B Gene

Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269 PubMed:21255211}.

Gene Ontology (GO) - Cellular Components for RAB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA,IEA 20375062
GO:0005768 endosome IEA --
GO:0005770 late endosome IEA,IDA 20375062
GO:0005774 vacuolar membrane IBA --
GO:0005794 Golgi apparatus IDA,IEA 20375062
genes like me logo Genes that share ontologies with RAB7B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for RAB7B Gene

Pathways & Interactions for RAB7B Gene

genes like me logo Genes that share pathways with RAB7B: view

Interacting Proteins for RAB7B Gene

Gene Ontology (GO) - Biological Process for RAB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0008333 endosome to lysosome transport IBA --
GO:0015031 protein transport IEA --
GO:0032482 Rab protein signal transduction IBA --
GO:0032755 positive regulation of interleukin-6 production IMP 20953574
genes like me logo Genes that share ontologies with RAB7B: view

No data available for SIGNOR curated interactions for RAB7B Gene

Drugs & Compounds for RAB7B Gene

No Compound Related Data Available

Transcripts for RAB7B Gene

mRNA/cDNA for RAB7B Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB7B Gene

RAB7B, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB7B Gene

No ASD Table

Relevant External Links for RAB7B Gene

GeneLoc Exon Structure for
RAB7B
ECgene alternative splicing isoforms for
RAB7B

Expression for RAB7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB7B Gene

Protein differential expression in normal tissues from HIPED for RAB7B Gene

This gene is overexpressed in Monocytes (46.5), Pancreas (7.6), and Oral epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAB7B Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB7B Gene:

RAB7B

SOURCE GeneReport for Unigene cluster for RAB7B Gene:

Hs.534612

mRNA Expression by UniProt/SwissProt for RAB7B Gene:

Q96AH8-RAB7B_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
genes like me logo Genes that share expression patterns with RAB7B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB7B Gene

Orthologs for RAB7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAB7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB7B 33
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC488576 33
  • 88.78 (n)
cow
(Bos Taurus)
Mammalia RAB7B 33
  • 86.6 (n)
mouse
(Mus musculus)
Mammalia 5430435G22Rik 33
  • 85.43 (n)
Rab7b 16
rat
(Rattus norvegicus)
Mammalia Rab7b 33
  • 85.09 (n)
chicken
(Gallus gallus)
Aves LOC771782 33
  • 73.53 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab7b 33
  • 62.98 (n)
Species where no ortholog for RAB7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB7B Gene

ENSEMBL:
Gene Tree for RAB7B (if available)
TreeFam:
Gene Tree for RAB7B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB7B: view image

Paralogs for RAB7B Gene

Variants for RAB7B Gene

Sequence variations from dbSNP and Humsavar for RAB7B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000046651 -- 205,987,562(-) C/A intron_variant
rs1000077648 -- 205,987,360(-) T/C intron_variant
rs1000208746 -- 205,982,700(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000244978 -- 205,992,566(-) C/A coding_sequence_variant, missense_variant
rs1000404032 -- 205,976,981(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Additional Variant Information for RAB7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB7B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RAB7B Gene

Disorders for RAB7B Gene

Additional Disease Information for RAB7B

No disorders were found for RAB7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB7B Gene

Publications for RAB7B Gene

  1. Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. (PMID: 15144907) Yang M … Cao X (Biochemical and biophysical research communications 2004) 2 3 4 22 58
  2. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. (PMID: 20953574) He D … Cai Z (Journal of molecular medicine (Berlin, Germany) 2011) 3 4 58
  3. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  4. Rab7b controls trafficking from endosomes to the TGN. (PMID: 20375062) Progida C … Bucci C (Journal of cell science 2010) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RAB7B Gene

Sources for RAB7B Gene

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