Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IBSP Gene

Aliases for IBSP Gene

  • Integrin Binding Sialoprotein 2 3 5
  • Bone Sialoprotein II 2 3 4
  • Cell-Binding Sialoprotein 3 4
  • BSP II 3 4
  • BNSP 3 4
  • Integrin-Binding Sialoprotein 4
  • Bone Sialoprotein 2 3
  • Bone Sialoprotein 2
  • BSP-II 3
  • SP-II 3
  • BSP 3

External Ids for IBSP Gene

Previous GeneCards Identifiers for IBSP Gene

  • GC04P088878
  • GC04P089022
  • GC04P089179
  • GC04P089077
  • GC04P088939
  • GC04P088720
  • GC04P084466

Summaries for IBSP Gene

Entrez Gene Summary for IBSP Gene

  • The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IBSP Gene

IBSP (Integrin Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include Chondromalacia and Fibrous Dysplasia. Among its related pathways are ECM proteoglycans and PI3K-Akt signaling pathway.

UniProtKB/Swiss-Prot for IBSP Gene

  • Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Gene Wiki entry for IBSP Gene

Additional gene information for IBSP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IBSP Gene

Genomics for IBSP Gene

GeneHancer (GH) Regulatory Elements for IBSP Gene

Promoters and enhancers for IBSP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I087799 Promoter 0.5 EPDnew 550.8 0.0 -15 0.1 IBSP CHCHD2P7
GH04I087657 Enhancer 0.9 ENCODE 10.6 -140.4 -140437 3.2 INSM2 MZF1 FEZF1 ZNF335 ZNF213 ZNF366 ZSCAN5C SCRT2 ATF7 ZNF391 ENSG00000249001 ENSG00000200024 DSPP IBSP DMP1 LOC105377323
GH04I087832 Promoter 0.5 EPDnew 10.6 +33.4 33400 0.1 MEPE IBSP SPARCL1 HSP90AB3P
GH04I087823 Promoter 0.5 EPDnew 10.3 +24.0 24007 0.1 MEPE IBSP HSP90AB3P
GH04I087806 Enhancer 0.8 Ensembl ENCODE 5.3 +7.4 7366 1.8 HLF CEBPB CEBPG FOXA1 GATA3 CREB1 FOS FOSL2 IBSP MEPE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IBSP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IBSP gene promoter:

Genomic Locations for IBSP Gene

Genomic Locations for IBSP Gene
12,900 bases
Plus strand

Genomic View for IBSP Gene

Genes around IBSP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IBSP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IBSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IBSP Gene

Proteins for IBSP Gene

  • Protein details for IBSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone sialoprotein 2
    Protein Accession:

    Protein attributes for IBSP Gene

    317 amino acids
    Molecular mass:
    35148 Da
    Quaternary structure:
    No Data Available
    • It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.

neXtProt entry for IBSP Gene

Post-translational modifications for IBSP Gene

  • N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
  • O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.
  • Sulfated on either Tyr-313 or Tyr-314.
  • Glycosylation at posLast=104104, isoforms=119, isoforms=122, isoforms=177, posLast=182182, posLast=190190, isoforms=227, isoforms=228, posLast=229229, isoforms=238, and isoforms=239
  • Modification sites at PhosphoSitePlus

Other Protein References for IBSP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IBSP Gene

Domains & Families for IBSP Gene

Gene Families for IBSP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for IBSP Gene


Suggested Antigen Peptide Sequences for IBSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IBSP: view

No data available for UniProtKB/Swiss-Prot for IBSP Gene

Function for IBSP Gene

Molecular function for IBSP Gene

GENATLAS Biochemistry:
sialoprotein,bone (cell adhesion molecule,RGD containing)
UniProtKB/Swiss-Prot Function:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Phenotypes From GWAS Catalog for IBSP Gene

Gene Ontology (GO) - Molecular Function for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005178 integrin binding IMP 24103036
genes like me logo Genes that share ontologies with IBSP: view
genes like me logo Genes that share phenotypes with IBSP: view

Animal Models for IBSP Gene

MGI Knock Outs for IBSP:

Animal Model Products

CRISPR Products

miRNA for IBSP Gene

miRTarBase miRNAs that target IBSP

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IBSP Gene

Localization for IBSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IBSP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IBSP gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0016020 membrane HDA,IDA 16210410
GO:0031012 extracellular matrix IBA --
GO:0031982 vesicle ISS --
genes like me logo Genes that share ontologies with IBSP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IBSP Gene

Pathways & Interactions for IBSP Gene

genes like me logo Genes that share pathways with IBSP: view

Pathways by source for IBSP Gene

Gene Ontology (GO) - Biological Process for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA,IDA 16210410
GO:0007155 cell adhesion ISS --
GO:0030198 extracellular matrix organization IEA,TAS --
GO:0030282 bone mineralization IEA --
GO:0031214 biomineral tissue development IEA --
genes like me logo Genes that share ontologies with IBSP: view

No data available for SIGNOR curated interactions for IBSP Gene

Drugs & Compounds for IBSP Gene

(29) Drugs for IBSP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(38) Additional Compounds for IBSP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IBSP: view

Transcripts for IBSP Gene

mRNA/cDNA for IBSP Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IBSP Gene

Integrin-binding sialoprotein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IBSP Gene

No ASD Table

Relevant External Links for IBSP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IBSP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IBSP Gene

mRNA differential expression in normal tissues according to GTEx for IBSP Gene

This gene is overexpressed in Artery - Coronary (x10.7), Pituitary (x7.2), and Brain - Amygdala (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of IBSP Gene:


SOURCE GeneReport for Unigene cluster for IBSP Gene:


Evidence on tissue expression from TISSUES for IBSP Gene

  • Bone(3.7)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with IBSP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IBSP Gene

Orthologs for IBSP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IBSP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IBSP 33 34
  • 98.53 (n)
(Canis familiaris)
Mammalia IBSP 33 34
  • 81.73 (n)
(Bos Taurus)
Mammalia IBSP 33 34
  • 80.68 (n)
(Mus musculus)
Mammalia Ibsp 33 16 34
  • 71.96 (n)
(Rattus norvegicus)
Mammalia Ibsp 33
  • 70.58 (n)
(Monodelphis domestica)
Mammalia IBSP 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia IBSP 34
  • 58 (a)
(Gallus gallus)
Aves IBSP 34
  • 41 (a)
(Anolis carolinensis)
Reptilia IBSP 34
  • 41 (a)
Species where no ortholog for IBSP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IBSP Gene

Gene Tree for IBSP (if available)
Gene Tree for IBSP (if available)

Paralogs for IBSP Gene

No data available for Paralogs for IBSP Gene

Variants for IBSP Gene

Sequence variations from dbSNP and Humsavar for IBSP Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000688658 -- 87,807,287(+) T/C intron_variant
rs1000931867 -- 87,808,851(+) T/G intron_variant
rs1000949301 -- 87,802,163(+) C/A/T intron_variant
rs1001010785 -- 87,799,551(+) A/G 5_prime_UTR_variant
rs1001319346 -- 87,803,850(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IBSP Gene

Variant ID Type Subtype PubMed ID
dgv322n21 CNV loss 19592680
nsv515943 CNV gain+loss 19592680

Variation tolerance for IBSP Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.86; 97.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IBSP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IBSP Gene

Disorders for IBSP Gene

MalaCards: The human disease database

(23) MalaCards diseases for IBSP Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fibrous dysplasia
  • fibrous dysplasia of bone
dentin dysplasia, type ii
  • dtdp2
osteogenic sarcoma
  • osteosarcoma; osrc
spastic paraplegia 25, autosomal recessive
  • spg25
- elite association - COSMIC cancer census association via MalaCards
Search IBSP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IBSP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IBSP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IBSP Gene

Publications for IBSP Gene

  1. Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding. (PMID: 11459848) Wuttke M … Maurer P (The Journal of biological chemistry 2001) 3 4 22 58
  2. Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. (PMID: 8061918) Kim RH … Sodek J (Matrix biology : journal of the International Society for Matrix Biology 1994) 3 4 22 58
  3. The human bone sialoprotein gene (IBSP): genomic localization and characterization. (PMID: 8406493) Kerr JM … Young MF (Genomics 1993) 2 3 4 58
  4. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. (PMID: 21533022) Duncan EL … Brown MA (PLoS genetics 2011) 3 44 58
  5. Predictive significance of bone sialoprotein and osteopontin for bone metastases in resected Chinese non-small-cell lung cancer patients: a large cohort retrospective study. (PMID: 19376608) Zhang L … Wang X (Lung cancer (Amsterdam, Netherlands) 2010) 3 22 58

Products for IBSP Gene

Sources for IBSP Gene

Loading form....