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Aliases for APOA2 Gene

Aliases for APOA2 Gene

  • Apolipoprotein A2 2 3 4 5
  • Apolipoprotein A-II 2 3
  • Apo-AII 3 4
  • ApoA-II 3 4
  • ApoAII 3

External Ids for APOA2 Gene

Previous GeneCards Identifiers for APOA2 Gene

  • GC01M158903
  • GC01M156924
  • GC01M157969
  • GC01M158408
  • GC01M158005
  • GC01M159458
  • GC01M132549

Summaries for APOA2 Gene

Entrez Gene Summary for APOA2 Gene

  • This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA2 Gene

APOA2 (Apolipoprotein A2) is a Protein Coding gene. Diseases associated with APOA2 include Hypercholesterolemia, Familial and Aapoaii Amyloidosis. Among its related pathways are PPAR Alpha Pathway and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and lipid binding.

UniProtKB/Swiss-Prot for APOA2 Gene

  • May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Gene Wiki entry for APOA2 Gene

Additional gene information for APOA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA2 Gene

Genomics for APOA2 Gene

GeneHancer (GH) Regulatory Elements for APOA2 Gene

Promoters and enhancers for APOA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J161222 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -2.7 -2668 6.6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TOMM40L APOA2 MIR5187 B4GALT3 ENSG00000228606 DEDD NDUFS2 FCER1G
GH01J161388 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -166.3 -166304 2.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 SDHC USP21 DUSP12 PPOX ATF6 CFAP126 NR1I3 APOA2 TOMM40L LOC148430
GH01J161304 Promoter/Enhancer 1.4 Ensembl ENCODE 11.4 -82.8 -82821 3 HDGF PKNOX1 ATF1 SIN3A YY1 POLR2B ZNF143 ZFP91 ATF7 SP5 FCER1G NDUFS2 NR1I3 TOMM40L APOA2 PCP4L1 SDHC FCGR2C MPZ LOC105371472
GH01J161381 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -159.2 -159193 2.1 CTCF ZNF654 REST RAD21 ATF2 RFX5 ZNF335 ZBTB48 ZNF143 HMBOX1 SDHC NR1I3 APOA2 TOMM40L ADAMTS4 NDUFS2 MPZ RRM2P2 ENSG00000283696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around APOA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the APOA2 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-4
  • E2F-3a
  • E2F-5
  • CREB
  • LCR-F1

Genomic Locations for APOA2 Gene

Genomic Locations for APOA2 Gene
1,340 bases
Minus strand
1,340 bases
Minus strand

Genomic View for APOA2 Gene

Genes around APOA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA2 Gene

Proteins for APOA2 Gene

  • Protein details for APOA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein A-II
    Protein Accession:
    Secondary Accessions:
    • B2R524

    Protein attributes for APOA2 Gene

    100 amino acids
    Molecular mass:
    11175 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1.

    Three dimensional structures from OCA and Proteopedia for APOA2 Gene

neXtProt entry for APOA2 Gene

Post-translational modifications for APOA2 Gene

No data available for DME Specific Peptides for APOA2 Gene

Domains & Families for APOA2 Gene

Gene Families for APOA2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for APOA2 Gene

Suggested Antigen Peptide Sequences for APOA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the apolipoprotein A2 family.
  • Belongs to the apolipoprotein A2 family.
genes like me logo Genes that share domains with APOA2: view

Function for APOA2 Gene

Molecular function for APOA2 Gene

UniProtKB/Swiss-Prot Function:
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
GENATLAS Biochemistry:
apolipoprotein A-II,associated with HDL (see TSG1M)

Phenotypes From GWAS Catalog for APOA2 Gene

Gene Ontology (GO) - Molecular Function for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity IDA 1606170
GO:0005515 protein binding IPI 11991719
GO:0005543 phospholipid binding IDA 218942
GO:0008035 high-density lipoprotein particle binding IEA,IBA --
GO:0008289 lipid binding IDA,IEA 14967812
genes like me logo Genes that share ontologies with APOA2: view
genes like me logo Genes that share phenotypes with APOA2: view

Animal Models for APOA2 Gene

MGI Knock Outs for APOA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOA2 Gene

Localization for APOA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOA2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 4
endosome 4
peroxisome 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space IEA --
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with APOA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for APOA2 Gene

Pathways & Interactions for APOA2 Gene

genes like me logo Genes that share pathways with APOA2: view

Gene Ontology (GO) - Biological Process for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002526 acute inflammatory response IEA --
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 12458630
GO:0006641 triglyceride metabolic process TAS 11551871
GO:0006656 phosphatidylcholine biosynthetic process IDA 14967812
genes like me logo Genes that share ontologies with APOA2: view

No data available for SIGNOR curated interactions for APOA2 Gene

Drugs & Compounds for APOA2 Gene

(16) Drugs for APOA2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Zinc Approved, Investigational Pharma Target 2430

(16) Additional Compounds for APOA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOA2: view

Transcripts for APOA2 Gene

mRNA/cDNA for APOA2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(591) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOA2 Gene

Apolipoprotein A-II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for APOA2

Alternative Splicing Database (ASD) splice patterns (SP) for APOA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP6: - - -

Relevant External Links for APOA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOA2 Gene

mRNA differential expression in normal tissues according to GTEx for APOA2 Gene

This gene is overexpressed in Liver (x52.5).

Protein differential expression in normal tissues from HIPED for APOA2 Gene

This gene is overexpressed in Plasma (25.6) and Serum (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOA2 Gene

Protein tissue co-expression partners for APOA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of APOA2 Gene:


SOURCE GeneReport for Unigene cluster for APOA2 Gene:


mRNA Expression by UniProt/SwissProt for APOA2 Gene:

Tissue specificity: Plasma; synthesized in the liver and intestine.

Evidence on tissue expression from TISSUES for APOA2 Gene

  • Liver(5)
  • Muscle(4.3)
  • Bone marrow(4)
  • Spleen(3.6)
  • Blood(3.1)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with APOA2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APOA2 Gene

Orthologs for APOA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APOA2 34 33
  • 98.67 (n)
(Canis familiaris)
Mammalia APOA2 34 33
  • 85.67 (n)
(Bos Taurus)
Mammalia APOA2 34 33
  • 79.33 (n)
(Mus musculus)
Mammalia Apoa2 16 34 33
  • 74.15 (n)
(Rattus norvegicus)
Mammalia Apoa2 33
  • 70.75 (n)
(Monodelphis domestica)
Mammalia APOA2 34
  • 56 (a)
Species where no ortholog for APOA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOA2 Gene

Gene Tree for APOA2 (if available)
Gene Tree for APOA2 (if available)
Evolutionary constrained regions (ECRs) for APOA2: view image

Paralogs for APOA2 Gene

No data available for Paralogs for APOA2 Gene

Variants for APOA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOA2 Gene

A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIM:107670].

Sequence variations from dbSNP and Humsavar for APOA2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs138452270 uncertain-significance, Apolipoprotein A-II deficiency 161,222,465(-) C/T coding_sequence_variant, synonymous_variant
rs201433891 uncertain-significance, Apolipoprotein A-II deficiency 161,223,422(-) C/A/G/T 5_prime_UTR_variant
rs3813625 uncertain-significance, Apolipoprotein A-II deficiency 161,223,617(-) G/A 5_prime_UTR_variant
rs6413453 likely-benign, Apolipoprotein A-II deficiency 161,222,526(-) G/A intron_variant

Variation tolerance for APOA2 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for APOA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Structural Variations from Database of Genomic Variants (DGV) for APOA2 Gene

Disorders for APOA2 Gene

MalaCards: The human disease database

(22) MalaCards diseases for APOA2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search APOA2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for APOA2 Gene

apolipoprotein A-II deficiency

Additional Disease Information for APOA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with APOA2: view

No data available for UniProtKB/Swiss-Prot for APOA2 Gene

Publications for APOA2 Gene

  1. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. (PMID: 19901143) Corella D … Ordovas JM (Archives of internal medicine 2009) 3 22 44 58
  2. Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. (PMID: 12576517) Pankhurst G … Stocker R (Journal of lipid research 2003) 3 4 22 58
  3. Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sample. (PMID: 12136239) Fullerton SM … Nickerson DA (Human genetics 2002) 3 4 44 58
  4. A splice-junction mutation responsible for familial apolipoprotein A-II deficiency. (PMID: 2107739) Deeb SS … Albers JJ (American journal of human genetics 1990) 3 4 22 58
  5. Expression and purification of recombinant human apolipoprotein A-II in Pichia pastoris. (PMID: 24116940) Su M … Wang D (Assay and drug development technologies 2013) 3 4 58

Products for APOA2 Gene

Sources for APOA2 Gene

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