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Aliases for HSPA6 Gene

Aliases for HSPA6 Gene

  • Heat Shock Protein Family A (Hsp70) Member 6 2 3 5
  • Heat Shock 70kDa Protein 6 (HSP70B) 2 3
  • Heat Shock 70kD Protein 6 (HSP70B) 2 3
  • Heat Shock 70 KDa Protein B 3 4
  • HSP70B 3 4
  • Heat Shock 70 KDa Protein 6 3

External Ids for HSPA6 Gene

Previous GeneCards Identifiers for HSPA6 Gene

  • GC01P159211
  • GC01P157225
  • GC01P158271
  • GC01P158764
  • GC01P158765
  • GC01P158308
  • GC01P159760
  • GC01P161495
  • GC01P132819

Summaries for HSPA6 Gene

GeneCards Summary for HSPA6 Gene

HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) is a Protein Coding gene. Diseases associated with HSPA6 include Hepatocellular Carcinoma. Among its related pathways are mRNA Splicing - Major Pathway and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include enzyme binding and heat shock protein binding. An important paralog of this gene is HSPA1A.

UniProtKB/Swiss-Prot for HSPA6 Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).

Gene Wiki entry for HSPA6 Gene

Additional gene information for HSPA6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA6 Gene

Genomics for HSPA6 Gene

GeneHancer (GH) Regulatory Elements for HSPA6 Gene

Promoters and enhancers for HSPA6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J161523 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 650.7 -0.3 -254 1.8 ATF1 ARNT SIN3A ZNF2 IRF4 BRCA1 ZNF48 YY1 NCOA2 GTF3C2 HSPA6 PIR56644 TRD-GTC10-1 TRG-GCC2-1 USP21 DUSP12 B4GALT3 DEDD RPS23P10 FCGR2C
GH01J161528 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +6.6 6620 4.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 TRG-TCC2-6 TRL-CAG1-6 USP21 DUSP12 PPOX FCGR2C DEDD FCGR2A B4GALT3 FCRLA
GH01J161113 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5.8 -406.3 -406275 8.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 NIT1 PIR38070 PFDN2 RPSAP18 DUSP12 LOC148430 B4GALT3 USP21 OLFML2B F11R
GH01J161611 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +87.8 87761 2.6 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 GC01P161612 GC01P161613 TRL-CAA6-1 USP21 DEDD FCGR2B DUSP12 B4GALT3 ATF6 FCGR2C
GH01J161421 Enhancer 1.2 Ensembl ENCODE 5.9 -102.5 -102465 1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 TRE-TTC4-2 USP21 DUSP12 DEDD B4GALT3 ATF6 PPOX HSPA6 HSPA7 LOC102724602
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA6 gene promoter:
  • STAT3
  • NRSF form 2
  • NRSF form 1
  • E47
  • Hand1
  • AML1a
  • p53
  • CUTL1
  • FOXD1

Genomic Locations for HSPA6 Gene

Genomic Locations for HSPA6 Gene
chr1:161,524,540-161,526,910
(GRCh38/hg38)
Size:
2,371 bases
Orientation:
Plus strand
chr1:161,494,036-161,496,687
(GRCh37/hg19)
Size:
2,652 bases
Orientation:
Plus strand

Genomic View for HSPA6 Gene

Genes around HSPA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA6 Gene

Proteins for HSPA6 Gene

  • Protein details for HSPA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17066-HSP76_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 6
    Protein Accession:
    P17066
    Secondary Accessions:
    • Q1HBA8
    • Q8IYK7
    • Q9BT95

    Protein attributes for HSPA6 Gene

    Size:
    643 amino acids
    Molecular mass:
    71028 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HSPA6 Gene

neXtProt entry for HSPA6 Gene

Post-translational modifications for HSPA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA6 Gene

Domains & Families for HSPA6 Gene

Gene Families for HSPA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA6 Gene

Suggested Antigen Peptide Sequences for HSPA6 Gene

Graphical View of Domain Structure for InterPro Entry

P17066

UniProtKB/Swiss-Prot:

HSP76_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA6: view

Function for HSPA6 Gene

Molecular function for HSPA6 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).
UniProtKB/Swiss-Prot Induction:
Only at higher temperatures, and no basal expression.
GENATLAS Biochemistry:
heat shock 70kDa protein A6,structurally related to aconitase

Phenotypes From GWAS Catalog for HSPA6 Gene

Gene Ontology (GO) - Molecular Function for HSPA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
GO:0019899 enzyme binding IPI 23921388
GO:0031072 heat shock protein binding IPI 21231916
genes like me logo Genes that share ontologies with HSPA6: view
genes like me logo Genes that share phenotypes with HSPA6: view

Animal Model Products

miRNA for HSPA6 Gene

miRTarBase miRNAs that target HSPA6

Clone Products

  • Addgene plasmids for HSPA6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA6 Gene

Localization for HSPA6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA6 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 4
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 24061851
GO:0005814 centriole IDA 24061851
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with HSPA6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA6 Gene

Pathways & Interactions for HSPA6 Gene

genes like me logo Genes that share pathways with HSPA6: view

Gene Ontology (GO) - Biological Process for HSPA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 2327978
GO:0034605 cellular response to heat IMP 21597468
GO:0034620 cellular response to unfolded protein IBA --
GO:0042026 protein refolding IDA 21231916
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with HSPA6: view

No data available for SIGNOR curated interactions for HSPA6 Gene

Drugs & Compounds for HSPA6 Gene

(1) Drugs for HSPA6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for HSPA6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA6: view

Transcripts for HSPA6 Gene

mRNA/cDNA for HSPA6 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(509) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA6 Gene

Heat shock 70kDa protein 6 (HSP70B):
Representative Sequences:

Clone Products

  • Addgene plasmids for HSPA6

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA6 Gene

No ASD Table

Relevant External Links for HSPA6 Gene

GeneLoc Exon Structure for
HSPA6
ECgene alternative splicing isoforms for
HSPA6

Expression for HSPA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA6 Gene

This gene is overexpressed in Whole Blood (x26.5).

Protein differential expression in normal tissues from HIPED for HSPA6 Gene

This gene is overexpressed in Saliva (24.1), Adipocyte (24.0), and Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA6 Gene



Protein tissue co-expression partners for HSPA6 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA6 Gene:

HSPA6

SOURCE GeneReport for Unigene cluster for HSPA6 Gene:

Hs.654614

Evidence on tissue expression from TISSUES for HSPA6 Gene

  • Lung(4.4)
  • Skin(4.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with HSPA6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA6 Gene

Orthologs for HSPA6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA6 34 33
  • 90.41 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA6 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 78 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 76 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mcm5 34
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-4 34 35
  • 77 (a)
ManyToMany
Hsc70-1 34 35
  • 76 (a)
ManyToMany
Hsp70Bc 35
  • 73 (a)
Hsp70Bb 35
  • 73 (a)
Hsp70Ba 35
  • 73 (a)
Hsp70Ab 35
  • 72 (a)
Hsp70Aa 35
  • 72 (a)
Hsc70-2 35
  • 71 (a)
Hsp68 35
  • 69 (a)
Hsc70-3 35
  • 61 (a)
CG7182 35
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 34 35
  • 78 (a)
OneToMany
hsp-2 35
  • 74 (a)
F44E5.5 35
  • 68 (a)
F44E5.4 35
  • 68 (a)
hsp-70 35
  • 66 (a)
hsp-3 35
  • 60 (a)
hsp-4 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 34
  • 71 (a)
OneToMany
SSZ1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 34
  • 75 (a)
ManyToMany
CSA.971 34
  • 72 (a)
ManyToMany
Species where no ortholog for HSPA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA6 Gene

ENSEMBL:
Gene Tree for HSPA6 (if available)
TreeFam:
Gene Tree for HSPA6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSPA6: view image

Paralogs for HSPA6 Gene

Paralogs for HSPA6 Gene

(16) SIMAP similar genes for HSPA6 Gene using alignment to 1 proteins:

  • HSP76_HUMAN

Pseudogenes.org Pseudogenes for HSPA6 Gene

genes like me logo Genes that share paralogs with HSPA6: view

Variants for HSPA6 Gene

Sequence variations from dbSNP and Humsavar for HSPA6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000837579 -- 161,523,429(+) T/G upstream_transcript_variant
rs1002108704 -- 161,523,889(+) C/A/T upstream_transcript_variant
rs1003814009 -- 161,524,128(+) C/T upstream_transcript_variant
rs1006012126 -- 161,523,811(+) G/A upstream_transcript_variant
rs1006686826 -- 161,524,603(+) A/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA6 Gene

Variant ID Type Subtype PubMed ID
dgv17n21 CNV loss 19592680
dgv22n16 CNV deletion 17901297
dgv447n100 CNV gain 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv74e199 CNV deletion 23128226
dgv85n67 CNV loss 20364138
dgv8e55 CNV gain 17911159
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv33393 CNV gain+loss 17666407
esv3587729 CNV loss 21293372
esv3587730 CNV gain 21293372
esv3890693 CNV loss 25118596
esv997087 CNV loss 20482838
nsv1161730 CNV duplication 26073780
nsv428257 CNV loss 18775914
nsv464173 CNV gain 19166990
nsv517640 CNV gain+loss 19592680
nsv519779 CNV loss 19592680
nsv548061 CNV loss 21841781
nsv818489 CNV gain 17921354
nsv819523 CNV loss 19587683
nsv820341 CNV duplication 20802225
nsv825176 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946464 CNV duplication 23825009

Variation tolerance for HSPA6 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.72; 89.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA6 Gene

Disorders for HSPA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPA6 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search HSPA6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSPA6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA6 Gene

Publications for HSPA6 Gene

  1. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PMID: 1346391) Leung TK … Lim L (Genomics 1992) 2 3 4 58
  2. The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. (PMID: 2327978) Leung TK … Lim L (The Biochemical journal 1990) 3 4 22 58
  3. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson ME … Falnes PØ (The Journal of biological chemistry 2013) 3 4 58
  4. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 44 58
  5. Heat shock protein 70B' (HSP70B') expression and release in response to human oxidized low density lipoprotein immune complexes in macrophages. (PMID: 20348092) Smith KJ … Hammad SM (The Journal of biological chemistry 2010) 3 22 58

Products for HSPA6 Gene

Sources for HSPA6 Gene

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