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Aliases for HSPA4 Gene

Aliases for HSPA4 Gene

  • Heat Shock Protein Family A (Hsp70) Member 4 2 3 5
  • Heat Shock 70-Related Protein APG-2 3 4
  • Heat Shock 70kDa Protein 4 2 3
  • Heat Shock 70kD Protein 4 2 3
  • Hsp70 RY 2 3
  • Epididymis Secretory Sperm Binding Protein Li 5a 3
  • Heat Shock 70 KDa Protein 4 3
  • Heat Shock Protein, 110 KDa 3
  • HEL-S-5a 3
  • HS24/P52 3
  • Hsp70RY 3
  • HSP70RY 4
  • APG-2 3
  • HSPH2 3
  • Hsp70 3
  • APG2 4
  • RY 3

External Ids for HSPA4 Gene

Previous GeneCards Identifiers for HSPA4 Gene

  • GC05P131909
  • GC05P132834
  • GC05P132418
  • GC05P132463
  • GC05P132415
  • GC05P127579

Summaries for HSPA4 Gene

GeneCards Summary for HSPA4 Gene

HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Ischemia and Leishmaniasis. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Validated targets of C-MYC transcriptional activation. An important paralog of this gene is HSPA4L.

Gene Wiki entry for HSPA4 Gene

Additional gene information for HSPA4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA4 Gene

Genomics for HSPA4 Gene

GeneHancer (GH) Regulatory Elements for HSPA4 Gene

Promoters and enhancers for HSPA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J133048 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 669.6 -0.9 -861 5.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 HSPA4 ENSG00000279691 GC05M133050 GC05M133049 ENSG00000202533 LOC105379175 IL4 ENSG00000224431 AFF4 MIR3936
GH05J132224 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -825.7 -825669 4.5 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF766 P4HA2 IL4 HSPA4 FNIP1 MIR3936HG PDLIM4 CSF2 IL3 MIR6830
GH05J132961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -89.0 -88994 3.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 SP3 ZNF610 AFF4 GC05M132963 LOC105379177 ENSG00000272023 ENSG00000231585 IL4 P4HA2-AS1 RAD50 CTB-3M24.3 ENSG00000224015
GH05J133025 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.2 -25.4 -25377 2.5 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZCCHC10 HSPA4 ENSG00000248648
GH05J133032 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -18.5 -18549 2 HDAC1 CLOCK FOXA2 ARID4B DMAP1 GATA2 CREM ZEB2 ZNF592 SMARCA4 HSPA4 ZCCHC10 AFF4 GC05M133049
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSPA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA4 gene promoter:
  • AP-1
  • CREB
  • deltaCREB
  • ATF-2
  • c-Jun

Genomic Locations for HSPA4 Gene

Genomic Locations for HSPA4 Gene
54,488 bases
Plus strand
54,488 bases
Plus strand

Genomic View for HSPA4 Gene

Genes around HSPA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA4 Gene

Proteins for HSPA4 Gene

  • Protein details for HSPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock 70 kDa protein 4
    Protein Accession:
    Secondary Accessions:
    • O95756
    • Q2TAL4
    • Q9BUK9

    Protein attributes for HSPA4 Gene

    840 amino acids
    Molecular mass:
    94331 Da
    Quaternary structure:
    • Interacts with TJP1/ZO-1.
    • Sequence=AAA02807.1; Type=Frameshift; Positions=567, 586, 697, 715, 722; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPA4 Gene


neXtProt entry for HSPA4 Gene

Post-translational modifications for HSPA4 Gene

  • Ubiquitination at Lys773, Lys754, Lys748, isoforms=736, Lys719, isoforms=711, isoforms=704, isoforms=697, Lys686, isoforms=679, isoforms=638, isoforms=573, Lys430, isoforms=422, isoforms=305, Lys221, Lys194, Lys124, Lys61, Lys53, and Lys44
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA4 Gene

Domains & Families for HSPA4 Gene

Gene Families for HSPA4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA4 Gene

Suggested Antigen Peptide Sequences for HSPA4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA4: view

Function for HSPA4 Gene

Molecular function for HSPA4 Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A4,structurally related to aconitase

Phenotypes From GWAS Catalog for HSPA4 Gene

Gene Ontology (GO) - Molecular Function for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding NAS,IEA 8335910
GO:0016887 ATPase activity IBA --
GO:0031072 heat shock protein binding IBA --
GO:0042623 ATPase activity, coupled IBA --
genes like me logo Genes that share ontologies with HSPA4: view
genes like me logo Genes that share phenotypes with HSPA4: view

Animal Models for HSPA4 Gene

MGI Knock Outs for HSPA4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA4

Clone Products

  • Addgene plasmids for HSPA4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA4 Gene

Localization for HSPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA4 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
plasma membrane 2
peroxisome 2
lysosome 2
golgi apparatus 2
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol IDA 21231916
GO:0070062 extracellular exosome IDA 21276792
genes like me logo Genes that share ontologies with HSPA4: view

Pathways & Interactions for HSPA4 Gene

genes like me logo Genes that share pathways with HSPA4: view

Gene Ontology (GO) - Biological Process for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein NAS 8335910
GO:0034605 cellular response to heat IBA --
GO:0034620 cellular response to unfolded protein IBA --
GO:0042026 protein refolding IBA --
GO:0045040 protein import into mitochondrial outer membrane IDA 15644312
genes like me logo Genes that share ontologies with HSPA4: view

No data available for SIGNOR curated interactions for HSPA4 Gene

Drugs & Compounds for HSPA4 Gene

(80) Drugs for HSPA4 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 12
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(71) Additional Compounds for HSPA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA4: view

Transcripts for HSPA4 Gene

mRNA/cDNA for HSPA4 Gene

Unigene Clusters for HSPA4 Gene

Heat shock 70kDa protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSPA4

Clone Products

  • Addgene plasmids for HSPA4

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4 Gene

No ASD Table

Relevant External Links for HSPA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA4 Gene

Protein differential expression in normal tissues from HIPED for HSPA4 Gene

This gene is overexpressed in Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSPA4 Gene

Protein tissue co-expression partners for HSPA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA4 Gene:


SOURCE GeneReport for Unigene cluster for HSPA4 Gene:


Evidence on tissue expression from TISSUES for HSPA4 Gene

  • Nervous system(4.9)
  • Blood(4.7)
  • Liver(4.7)
  • Skin(4.7)
  • Muscle(3.6)
  • Stomach(3.6)
  • Heart(3.5)
  • Kidney(3.5)
  • Spleen(3.3)
  • Eye(3.2)
  • Lung(3.2)
  • Intestine(3.1)
  • Adrenal gland(2.8)
  • Lymph node(2.8)
  • Pancreas(2.5)
  • Bone marrow(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with HSPA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA4 Gene

Orthologs for HSPA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPA4 34 33
  • 99.84 (n)
(Bos Taurus)
Mammalia HSPA4 34 33
  • 94.8 (n)
(Canis familiaris)
Mammalia HSPA4 34 33
  • 94.4 (n)
(Mus musculus)
Mammalia Hspa4 16 34 33
  • 90.6 (n)
(Rattus norvegicus)
Mammalia Hspa4 33
  • 90.36 (n)
(Ornithorhynchus anatinus)
Mammalia HSPA4 34
  • 90 (a)
(Monodelphis domestica)
Mammalia HSPA4 34
  • 79 (a)
(Gallus gallus)
Aves HSPA4 34 33
  • 79.94 (n)
(Anolis carolinensis)
Reptilia HSPA4 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa4 33
  • 76.69 (n)
MGC76295 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5799 33
(Danio rerio)
Actinopterygii hspa4b 34
  • 73 (a)
hspa4a 34 33
  • 68.11 (n)
wufc41d05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10287 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010331 33
  • 53.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70Cb 34 33
  • 51.89 (n)
(Caenorhabditis elegans)
Secernentea C30C11.4 35 33
  • 51.41 (n)
hsp-110 34
  • 45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24597g 33
  • 50 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 34 33
  • 49.53 (n)
SSE2 34
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR212W 33
  • 48.15 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP91 33
  • 50.85 (n)
(Oryza sativa)
Liliopsida Os01g0180800 33
  • 51.8 (n)
Os.26495 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pss1 33
  • 51.49 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05269 33
  • 49.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9760 34
  • 44 (a)
Species where no ortholog for HSPA4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA4 Gene

Gene Tree for HSPA4 (if available)
Gene Tree for HSPA4 (if available)
Evolutionary constrained regions (ECRs) for HSPA4: view image

Paralogs for HSPA4 Gene

Paralogs for HSPA4 Gene

(15) SIMAP similar genes for HSPA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPA4: view

Variants for HSPA4 Gene

Sequence variations from dbSNP and Humsavar for HSPA4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000004298 -- 133,089,719(+) A/G intron_variant
rs1000120054 -- 133,089,881(+) T/C intron_variant
rs1000130387 -- 133,050,225(+) G/C upstream_transcript_variant
rs1000175691 -- 133,085,592(+) GGAGG/GGAGGAGG intron_variant
rs1000207425 -- 133,076,401(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA4 Gene

Variant ID Type Subtype PubMed ID
nsv1128190 CNV deletion 24896259
nsv830490 CNV gain 17160897

Variation tolerance for HSPA4 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA4 Gene

Disorders for HSPA4 Gene

MalaCards: The human disease database

(25) MalaCards diseases for HSPA4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute coronary syndrome
  • cutaneous leishmaniasis
transient cerebral ischemia
  • tia
visceral leishmaniasis
  • infection by visceral leishmaniasis
salpingitis isthmica nodosa
- elite association - COSMIC cancer census association via MalaCards
Search HSPA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSPA4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA4 Gene

Publications for HSPA4 Gene

  1. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. (PMID: 8335910) Fathallah DM … Arnaout MA (Journal of immunology (Baltimore, Md. : 1950) 1993) 2 3 4 58
  2. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts. (PMID: 20069064) Ayub H … Qamar R (Molecular vision 2010) 3 22 58
  3. Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. (PMID: 20053985) Hwang CY … Song B (The Journal of biological chemistry 2010) 3 22 58
  4. [The significance of the changes in expressions of heat shock protein 70 and heme oxygenase-1 in the myocardium in patients died suddenly due to acute myocardial infarction]. (PMID: 20170613) Zuo LP … Ma ZF (Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 2010) 3 22 58
  5. Geldanamycin inhibits TGF-beta signaling through induction of Hsp70. (PMID: 19995547) Yun CH … Lee HJ (Archives of biochemistry and biophysics 2010) 3 22 58

Products for HSPA4 Gene

  • Addgene plasmids for HSPA4

Sources for HSPA4 Gene

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