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Aliases for HOXC8 Gene

Aliases for HOXC8 Gene

  • Homeobox C8 2 3 5
  • Homeobox Protein Hox-3A 3 4
  • Homeo Box C8 2 3
  • HOX3A 3 4
  • Hox-3.1, Mouse, Homolog Of 3
  • Homeobox Protein Hox-C8 3
  • Homeo Box 3A 3
  • HOX3 3

External Ids for HOXC8 Gene

Previous HGNC Symbols for HOXC8 Gene

  • HOX3
  • HOX3A

Previous GeneCards Identifiers for HOXC8 Gene

  • GC12M054416
  • GC12P054515
  • GC12P054119
  • GC12P052689
  • GC12P054402
  • GC12P051440

Summaries for HOXC8 Gene

Entrez Gene Summary for HOXC8 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC8 Gene

HOXC8 (Homeobox C8) is a Protein Coding gene. Among its related pathways are Differentiation of white and brown adipocyte. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD8.

UniProtKB/Swiss-Prot for HOXC8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXC8 Gene

Additional gene information for HOXC8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC8 Gene

Genomics for HOXC8 Gene

GeneHancer (GH) Regulatory Elements for HOXC8 Gene

Promoters and enhancers for HOXC8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J054009 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 665.2 +13.0 12990 25.8 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B CBX5 HOXC8 HOXC4 HOXC6 HOXC5 GC12P054078 GC12P054102 PIR46464 PIR59725 PIR59985 PIR53546
GH12J053971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 667.5 -18.9 -18863 36.8 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC HOXC8 HOXC5 HOXC11 HOXC9 HOXC6 HOXC10 GC12P054010 GC12P054063 MIR196A2 HNRNPA1
GH12J054008 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 650.7 -0.2 -164 0.2 ZBTB26 EZH2 HOXC8 GC12P054104 PIR54488 GC12P054109 HOXC6 ENSG00000273049
GH12J054323 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 19.3 +318.8 318781 8.3 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 COPZ1 ENSG00000258344 SP1 PCBP2 ATF7 HOXC8 HOXC9 HNRNPA1 ENSG00000258086 TARBP2
GH12J053378 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.3 -628.2 -628179 5.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 SP1 PIR43704 PRR13 AAAS HOXC8 HOXC9 ENSG00000258086 AMHR2 SP7 HOXC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HOXC8 gene promoter:
  • Sp1
  • ATF

Genomic Locations for HOXC8 Gene

Genomic Locations for HOXC8 Gene
chr12:54,009,106-54,012,763
(GRCh38/hg38)
Size:
3,658 bases
Orientation:
Plus strand
chr12:54,402,832-54,407,570
(GRCh37/hg19)
Size:
4,739 bases
Orientation:
Plus strand

Genomic View for HOXC8 Gene

Genes around HOXC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC8 Gene

Proteins for HOXC8 Gene

  • Protein details for HOXC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31273-HXC8_HUMAN
    Recommended name:
    Homeobox protein Hox-C8
    Protein Accession:
    P31273
    Secondary Accessions:
    • A8K4J4
    • O15221
    • O15362

    Protein attributes for HOXC8 Gene

    Size:
    242 amino acids
    Molecular mass:
    27755 Da
    Quaternary structure:
    • Interacts with SMAD1 and HOMEZ.

neXtProt entry for HOXC8 Gene

Post-translational modifications for HOXC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC8 Gene

Domains & Families for HOXC8 Gene

Gene Families for HOXC8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HOXC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31273

UniProtKB/Swiss-Prot:

HXC8_HUMAN :
  • Belongs to the Antp homeobox family.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXC8: view

Function for HOXC8 Gene

Molecular function for HOXC8 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation of the limb

Phenotypes From GWAS Catalog for HOXC8 Gene

Gene Ontology (GO) - Molecular Function for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC8: view
genes like me logo Genes that share phenotypes with HOXC8: view

Animal Models for HOXC8 Gene

MGI Knock Outs for HOXC8:

Animal Model Products

CRISPR Products

miRNA for HOXC8 Gene

miRTarBase miRNAs that target HOXC8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC8 Gene

Localization for HOXC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXC8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with HOXC8: view

Pathways & Interactions for HOXC8 Gene

genes like me logo Genes that share pathways with HOXC8: view

Pathways by source for HOXC8 Gene

1 BioSystems pathway for HOXC8 Gene

SIGNOR curated interactions for HOXC8 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXC8: view

Drugs & Compounds for HOXC8 Gene

No Compound Related Data Available

Transcripts for HOXC8 Gene

mRNA/cDNA for HOXC8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC8 Gene

Homeobox C8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC8

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC8 Gene

No ASD Table

Relevant External Links for HOXC8 Gene

GeneLoc Exon Structure for
HOXC8
ECgene alternative splicing isoforms for
HOXC8

Expression for HOXC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOXC8 Gene



NURSA nuclear receptor signaling pathways regulating expression of HOXC8 Gene:

HOXC8

SOURCE GeneReport for Unigene cluster for HOXC8 Gene:

Hs.664500

Evidence on tissue expression from TISSUES for HOXC8 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with HOXC8: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC8 Gene

Orthologs for HOXC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC8 34 33
  • 99.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOXC8 34 33
  • 97.38 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc8 33
  • 95.87 (n)
mouse
(Mus musculus)
Mammalia Hoxc8 16 34 33
  • 95.59 (n)
dog
(Canis familiaris)
Mammalia LOC607625 33
  • 95.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC8 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC8 33
  • 82.72 (n)
lizard
(Anolis carolinensis)
Reptilia HOXC8 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc8 33
  • 83.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia xhoxc8 33
zebrafish
(Danio rerio)
Actinopterygii hoxc8a 34 33 33
  • 75.12 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ubx 34
  • 20 (a)
ManyToMany
abd-A 34
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mab-5 34
  • 33 (a)
ManyToMany
lin-39 34
  • 26 (a)
ManyToMany
Species where no ortholog for HOXC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXC8 Gene

ENSEMBL:
Gene Tree for HOXC8 (if available)
TreeFam:
Gene Tree for HOXC8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXC8: view image

Paralogs for HOXC8 Gene

(7) SIMAP similar genes for HOXC8 Gene using alignment to 1 proteins:

  • HXC8_HUMAN
genes like me logo Genes that share paralogs with HOXC8: view

Variants for HOXC8 Gene

Sequence variations from dbSNP and Humsavar for HOXC8 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000190438 -- 54,009,210(+) G/C 5_prime_UTR_variant
rs1001415308 -- 54,012,543(+) C/T 3_prime_UTR_variant
rs1001904470 -- 54,010,305(+) A/C intron_variant
rs1002318335 -- 54,010,732(+) C/T intron_variant
rs1002568484 -- 54,013,187(+) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HOXC8 Gene

Variant ID Type Subtype PubMed ID
esv2672088 CNV deletion 23128226
esv2759900 CNV gain+loss 17122850
nsv1070530 CNV deletion 25765185
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Variation tolerance for HOXC8 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXC8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC8 Gene

Disorders for HOXC8 Gene

Additional Disease Information for HOXC8

No disorders were found for HOXC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC8 Gene

Publications for HOXC8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D … Ruddle FH (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  3. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4 58
  4. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PMID: 11139569) Wan M … Cao X (The Journal of biological chemistry 2001) 3 22 58
  5. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PMID: 9357979) Flagiello D … Malfoy B (FEBS letters 1997) 3 4 58

Products for HOXC8 Gene

Sources for HOXC8 Gene

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