Aliases for TLX1 Gene
External Ids for TLX1 Gene
Previous HGNC Symbols for TLX1 Gene
Previous GeneCards Identifiers for TLX1 Gene
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
GeneCards Summary for TLX1 Gene
TLX1 (T Cell Leukemia Homeobox 1) is a Protein Coding gene. Diseases associated with TLX1 include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Cell Differentiation - Index and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is TLX3.
UniProtKB/Swiss-Prot for TLX1 Gene
Controls the genesis of the spleen. Binds to the DNA sequence 5-GGCGGTAAGTGG-3.