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Aliases for ANXA3 Gene

Aliases for ANXA3 Gene

  • Annexin A3 2 3 5
  • Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase 3 4
  • Placental Anticoagulant Protein III 3 4
  • 35-Alpha Calcimedin 3 4
  • Lipocortin III 3 4
  • Annexin-3 3 4
  • PAP-III 3 4
  • ANX3 3 4
  • Annexin III (Lipocortin III, 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase, Placental Anticoagulant Protein III, Calcimedin 35-Alpha) 3
  • Annexin III (Lipocortin III) 3
  • Calcimedin 35-Alpha 3
  • Annexin III 4

External Ids for ANXA3 Gene

Previous HGNC Symbols for ANXA3 Gene

  • ANX3

Previous GeneCards Identifiers for ANXA3 Gene

  • GC04P079403
  • GC04P079746
  • GC04P079865
  • GC04P079933
  • GC04P079925
  • GC04P079830
  • GC04P075219
  • GC04P079472

Summaries for ANXA3 Gene

Entrez Gene Summary for ANXA3 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA3 Gene

ANXA3 (Annexin A3) is a Protein Coding gene. Among its related pathways are Prostaglandin Synthesis and Regulation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA3 Gene

  • Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Gene Wiki entry for ANXA3 Gene

Additional gene information for ANXA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA3 Gene

Genomics for ANXA3 Gene

GeneHancer (GH) Regulatory Elements for ANXA3 Gene

Promoters and enhancers for ANXA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I078550 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 582.2 +1.2 1231 3.8 NEUROD1 SIN3A FEZF1 ZNF48 GLIS2 ELK1 KLF7 FOS ATF7 SP3 ANXA3 FRAS1 GC04P078478 ENSG00000200998 GC04M078633
GH04I078555 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.6 +7.3 7280 7.5 PKNOX1 TEAD4 JUN MAX CEBPG FEZF1 FOSL1 CTBP1 GATA3 POLR2A ANXA3 ENSG00000200998 GC04M078633 GC04P078478
GH04I078563 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 +15.7 15707 7 PKNOX1 SIN3A FEZF1 BATF RAD21 BRCA1 RARA ATF7 FOS IKZF2 ANXA3 ENSG00000200998 GC04M078633
GH04I078542 Enhancer 0.7 ENCODE dbSUPER 20.2 -8.3 -8328 2.3 SP1 JUND ZNF316 CEBPB FOSL2 FOS TCF7L2 ANXA3 GC04M078509 GC04P078478 FRAS1
GH04I078529 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 14.6 -21.7 -21732 1.3 JUND FOSL2 FOS FRAS1 ANXA3 GC04M078509 GC04P078478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ANXA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ANXA3 gene promoter:

Genomic Locations for ANXA3 Gene

Genomic Locations for ANXA3 Gene
chr4:78,551,519-78,610,451
(GRCh38/hg38)
Size:
58,933 bases
Orientation:
Plus strand
chr4:79,472,673-79,531,605
(GRCh37/hg19)

Genomic View for ANXA3 Gene

Genes around ANXA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA3 Gene

Proteins for ANXA3 Gene

  • Protein details for ANXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12429-ANXA3_HUMAN
    Recommended name:
    Annexin A3
    Protein Accession:
    P12429
    Secondary Accessions:
    • B2R9W6
    • Q6LET2

    Protein attributes for ANXA3 Gene

    Size:
    323 amino acids
    Molecular mass:
    36375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA3 Gene

neXtProt entry for ANXA3 Gene

Post-translational modifications for ANXA3 Gene

  • Ubiquitination at Lys210
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA3 Gene

No data available for DME Specific Peptides for ANXA3 Gene

Domains & Families for ANXA3 Gene

Gene Families for ANXA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ANXA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12429

UniProtKB/Swiss-Prot:

ANXA3_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA3: view

Function for ANXA3 Gene

Molecular function for ANXA3 Gene

GENATLAS Biochemistry:
annexin A3,calelectrin 32.5
UniProtKB/Swiss-Prot Function:
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Phenotypes From GWAS Catalog for ANXA3 Gene

Gene Ontology (GO) - Molecular Function for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA,IDA 2138016
GO:0019834 phospholipase A2 inhibitor activity IEA --
GO:0048306 calcium-dependent protein binding IPI 15226301
genes like me logo Genes that share ontologies with ANXA3: view
genes like me logo Genes that share phenotypes with ANXA3: view

Animal Models for ANXA3 Gene

MGI Knock Outs for ANXA3:

miRNA for ANXA3 Gene

miRTarBase miRNAs that target ANXA3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA3 Gene

Localization for ANXA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 2
nucleus 2
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17205602
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA 7526843
GO:0016020 membrane IDA 17205602
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with ANXA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA3 Gene

Pathways & Interactions for ANXA3 Gene

genes like me logo Genes that share pathways with ANXA3: view

Pathways by source for ANXA3 Gene

1 BioSystems pathway for ANXA3 Gene

Gene Ontology (GO) - Biological Process for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IDA 9497492
GO:0010595 positive regulation of endothelial cell migration IDA 16236264
GO:0021766 hippocampus development IEA --
GO:0031100 animal organ regeneration IEA --
GO:0042742 defense response to bacterium IDA 9497492
genes like me logo Genes that share ontologies with ANXA3: view

No data available for SIGNOR curated interactions for ANXA3 Gene

Drugs & Compounds for ANXA3 Gene

(6) Drugs for ANXA3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Glycerol Approved, Investigational Pharma 175
Water Approved Pharma 0
Ethanolamine Experimental Pharma Target 0

(9) Additional Compounds for ANXA3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inositol cyclic phosphate
  • 1D-Myo-Inositol 1,2-cyclic phosphate
  • D-Myo-Inositol 1,2-cyclic phosphate
  • Inositol 1,2-cyclic phosphate
  • Inositol cyclic phosphate
  • Inositol cyclic-1,2-monophosphate
43119-57-9
Inositol phosphate
  • 1D-Myo-Inositol 1-monophosphate
  • 1D-Myo-Inositol 1-phosphate
  • D-Myo-Inositol-1-Phosphate
  • Inositol 1-monophosphate
15421-51-9
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
573-35-3
genes like me logo Genes that share compounds with ANXA3: view

Transcripts for ANXA3 Gene

Unigene Clusters for ANXA3 Gene

Annexin A3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for ANXA3 Gene

GeneLoc Exon Structure for
ANXA3
ECgene alternative splicing isoforms for
ANXA3

Expression for ANXA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA3 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA3 Gene

This gene is overexpressed in Whole Blood (x16.5).

Protein differential expression in normal tissues from HIPED for ANXA3 Gene

This gene is overexpressed in Neutrophil (12.0) and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANXA3 Gene



Protein tissue co-expression partners for ANXA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANXA3 Gene:

ANXA3

SOURCE GeneReport for Unigene cluster for ANXA3 Gene:

Hs.480042

Evidence on tissue expression from TISSUES for ANXA3 Gene

  • Blood(4.5)
  • Muscle(4.2)
  • Lung(2.9)
  • Liver(2.5)
  • Kidney(2.4)
  • Heart(2.2)
  • Bone marrow(2.1)
  • Pancreas(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ANXA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA3 Gene

Orthologs for ANXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA3 34 33
  • 98.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA3 33 34
  • 89.16 (n)
cow
(Bos Taurus)
Mammalia ANXA3 33 34
  • 88.03 (n)
mouse
(Mus musculus)
Mammalia Anxa3 16 34 33
  • 84.73 (n)
rat
(Rattus norvegicus)
Mammalia Anxa3 33
  • 83.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ANXA3 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA3 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5303 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3863 33
zebrafish
(Danio rerio)
Actinopterygii anxa3b 33 34
  • 60.08 (n)
anxa3a 34
  • 49 (a)
OneToMany
wufb60b03 33
fruit fly
(Drosophila melanogaster)
Insecta AnnX 35
  • 44 (a)
Anxb11 35
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-2 35 34
  • 44 (a)
nex-3 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for ANXA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA3 Gene

ENSEMBL:
Gene Tree for ANXA3 (if available)
TreeFam:
Gene Tree for ANXA3 (if available)

Paralogs for ANXA3 Gene

Paralogs for ANXA3 Gene

genes like me logo Genes that share paralogs with ANXA3: view

Variants for ANXA3 Gene

Sequence variations from dbSNP and Humsavar for ANXA3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000038790 -- 78,567,940(+) C/T intron_variant
rs1000082964 -- 78,555,073(+) C/G intron_variant
rs10001246 -- 78,606,118(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000175938 -- 78,593,283(+) A/G intron_variant
rs1000195541 -- 78,587,078(+) G/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA3 Gene

Variant ID Type Subtype PubMed ID
esv3351562 CNV insertion 20981092
esv3352391 CNV insertion 20981092
esv3601108 CNV loss 21293372
nsv1006026 CNV loss 25217958
nsv1009633 CNV gain 25217958
nsv7363 OTHER inversion 18451855

Variation tolerance for ANXA3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ANXA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANXA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA3 Gene

Disorders for ANXA3 Gene

Additional Disease Information for ANXA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ANXA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA3 Gene

Publications for ANXA3 Gene

  1. Chromosomal localization of the human annexin III (ANX3) gene. (PMID: 1830024) Tait JF … Disteche CM (Genomics 1991) 2 3 4 22 58
  2. The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. (PMID: 8639653) Favier-Perron B … Russo-Marie F (Biochemistry 1996) 3 4 22 58
  3. Structure and polymorphisms of the human annexin III (ANX3) gene. (PMID: 8276419) Tait JF … Cookson BT (Genomics 1993) 3 4 22 58
  4. Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. (PMID: 2138632) Ernst JD … Jaye D (The Journal of clinical investigation 1990) 3 4 22 58
  5. Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. (PMID: 2159184) Ross TS … Majerus PW (Science (New York, N.Y.) 1990) 3 4 22 58

Products for ANXA3 Gene

Sources for ANXA3 Gene

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