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Aliases for HIST1H1B Gene

Aliases for HIST1H1B Gene

  • Histone Cluster 1 H1 Family Member B 2 3 5
  • H1 Histone Family, Member 5 2 3
  • Histone Cluster 1, H1b 2 3
  • Histone 1, H1b 2 3
  • Histone H1s-3 3 4
  • Histone H1a 3 4
  • Histone H1b 3 4
  • H1F5 3 4
  • Histone H1.5 3
  • H1s-3 3
  • H1.5 3
  • H1B 3
  • H1 3

External Ids for HIST1H1B Gene

Previous HGNC Symbols for HIST1H1B Gene

  • H1F5

Previous GeneCards Identifiers for HIST1H1B Gene

  • GC06M027893
  • GC06M027942
  • GC06M027835
  • GC06M027644
  • GC06M027894
  • GC06M027911
  • GC06M027934
  • GC06M028000
  • GC06M028023
  • GC06M028045
  • GC06M028054
  • GC06M028092

Summaries for HIST1H1B Gene

Entrez Gene Summary for HIST1H1B Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H1B Gene

HIST1H1B (Histone Cluster 1 H1 Family Member B) is a Protein Coding gene. Diseases associated with HIST1H1B include Griscelli Syndrome, Type 1. Among its related pathways are Apoptotic cleavage of cellular proteins and Cell cycle_Chromosome condensation in prometaphase. Gene Ontology (GO) annotations related to this gene include chromatin DNA binding. An important paralog of this gene is HIST1H1E.

UniProtKB/Swiss-Prot for HIST1H1B Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1B Gene

Additional gene information for HIST1H1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1B Gene

Genomics for HIST1H1B Gene

GeneHancer (GH) Regulatory Elements for HIST1H1B Gene

Promoters and enhancers for HIST1H1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J027862 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.1 -1087 12.7 HNRNPUL1 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 GC06M028145 HIST1H1B PIR38036 PIR60513 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZNF603P ZSCAN12
GH06J027834 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.2 +30.3 30288 6.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 SP3 NFYC MEF2D HIST1H2BN HIST1H2AK GC06M027849 ZKSCAN3 ZKSCAN4 ZKSCAN8 ZSCAN9 ZSCAN12 HNRNPA1P1 HIST1H2BPS2
GH06J027821 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.4 +43.7 43676 4.6 HDGF HNRNPUL1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A YY1 POLR2B GC06P027825 HIST1H4J HIST1H2BN ZKSCAN4 ZSCAN9 ZKSCAN8 ZSCAN12 ZKSCAN3 HIST1H3J HIST1H1B
GH06J027887 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -25.9 -25900 11.9 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 NFYC SSRP1 ZNF610 RCOR2 HIST1H2AM HIST1H2BO HIST1H3J GC06M028139 PIR50251 PIR61297 PIR62073 PIR45952 ZKSCAN8 ZKSCAN3
GH06J027805 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 2.7 +55.5 55466 12.7 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NFYC ZKSCAN4 ZKSCAN8 ZKSCAN3 ZSCAN9 ZSCAN12 ZNF603P ZSCAN26 ZNF192P1 HIST1H4K ZNF204P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HIST1H1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H1B gene promoter:
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • Egr-3
  • Brachyury
  • E47
  • Tal-1

Genomic Locations for HIST1H1B Gene

Genomic Locations for HIST1H1B Gene
chr6:27,866,792-27,867,581
(GRCh38/hg38)
Size:
790 bases
Orientation:
Minus strand
chr6:27,834,570-27,835,359
(GRCh37/hg19)
Size:
790 bases
Orientation:
Minus strand

Genomic View for HIST1H1B Gene

Genes around HIST1H1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1B Gene

Proteins for HIST1H1B Gene

  • Protein details for HIST1H1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16401-H15_HUMAN
    Recommended name:
    Histone H1.5
    Protein Accession:
    P16401
    Secondary Accessions:
    • Q14529
    • Q3MJ42

    Protein attributes for HIST1H1B Gene

    Size:
    226 amino acids
    Molecular mass:
    22580 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HIST1H1B Gene

neXtProt entry for HIST1H1B Gene

Post-translational modifications for HIST1H1B Gene

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by GSK3B during mitosis in prometaphase and dephosphorylated in telophase.
  • Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Ubiquitination at Lys78, Lys67, isoforms=49, and Lys17
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H1B Gene

Domains & Families for HIST1H1B Gene

Gene Families for HIST1H1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HIST1H1B Gene

Suggested Antigen Peptide Sequences for HIST1H1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16401

UniProtKB/Swiss-Prot:

H15_HUMAN :
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Belongs to the histone H1/H5 family.
Domain:
  • The C-terminal domain is required for high-affinity binding to chromatin.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1B: view

Function for HIST1H1B Gene

Molecular function for HIST1H1B Gene

UniProtKB/Swiss-Prot Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Phenotypes From GWAS Catalog for HIST1H1B Gene

Gene Ontology (GO) - Molecular Function for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0031490 chromatin DNA binding IMP 15911621
GO:0042826 histone deacetylase binding IPI 22956909
genes like me logo Genes that share ontologies with HIST1H1B: view
genes like me logo Genes that share phenotypes with HIST1H1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H1B Gene

Localization for HIST1H1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1B Gene

Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H1B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IDA 19882353
GO:0005634 nucleus IDA 21383955
GO:0005694 chromosome IEA --
GO:0005720 nuclear heterochromatin IDA 15911621
genes like me logo Genes that share ontologies with HIST1H1B: view

Pathways & Interactions for HIST1H1B Gene

genes like me logo Genes that share pathways with HIST1H1B: view

Pathways by source for HIST1H1B Gene

SIGNOR curated interactions for HIST1H1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 22956909
GO:0006325 chromatin organization IMP 22956909
GO:0006334 nucleosome assembly IEA --
GO:0030307 positive regulation of cell growth IMP 22956909
GO:0050821 protein stabilization IMP 22956909
genes like me logo Genes that share ontologies with HIST1H1B: view

Drugs & Compounds for HIST1H1B Gene

(3) Drugs for HIST1H1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for HIST1H1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST1H1B: view

Transcripts for HIST1H1B Gene

mRNA/cDNA for HIST1H1B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1B Gene

Histone cluster 1, H1b:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HIST1H1B

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1B Gene

No ASD Table

Relevant External Links for HIST1H1B Gene

GeneLoc Exon Structure for
HIST1H1B
ECgene alternative splicing isoforms for
HIST1H1B

Expression for HIST1H1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1B Gene

This gene is overexpressed in Whole Blood (x12.2) and Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for HIST1H1B Gene

This gene is overexpressed in NK cells (10.1), Neutrophil (7.1), Fetal testis (6.5), and Fetal gut (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H1B Gene



Protein tissue co-expression partners for HIST1H1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIST1H1B Gene:

HIST1H1B

SOURCE GeneReport for Unigene cluster for HIST1H1B Gene:

Hs.131956

mRNA Expression by UniProt/SwissProt for HIST1H1B Gene:

P16401-H15_HUMAN
Tissue specificity: Ubiquitous. Expressed in the majority of the cell lines tested and in testis.

Evidence on tissue expression from TISSUES for HIST1H1B Gene

  • Spleen(4.5)
  • Liver(4.4)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with HIST1H1B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H1B Gene

Orthologs for HIST1H1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H1B 34
  • 100 (a)
OneToOne
LOC471906 33
  • 99.41 (n)
mouse
(Mus musculus)
Mammalia Hist1h1b 34
  • 92 (a)
OneToMany
Gm6970 34
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC488305 33
  • 83.42 (n)
cow
(Bos Taurus)
Mammalia HIST1H1D 34
  • 83 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves HIST1H111L 34
  • 76 (a)
ManyToMany
HIST1H111R 34
  • 76 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8334 33
zebrafish
(Danio rerio)
Actinopterygii CU457819.3 34
  • 72 (a)
ManyToMany
CABZ01086354.1 34
  • 70 (a)
ManyToMany
histh1l 34
  • 70 (a)
ManyToMany
FP325123.1 34
  • 70 (a)
ManyToMany
si:dkey-261m9.12 34
  • 68 (a)
ManyToMany
zgc:153405 34
  • 68 (a)
ManyToMany
zgc:110425 34
  • 68 (a)
ManyToMany
si:ch211-113a14.24 34
  • 67 (a)
ManyToMany
si:ch211-113a14.18 34
  • 67 (a)
ManyToMany
si:dkey-108k21.14 34
  • 67 (a)
ManyToMany
si:ch211-113a14.12 34
  • 67 (a)
ManyToMany
si:dkey-108k21.10 34
  • 66 (a)
ManyToMany
zgc:163061 34 34
  • 66 (a)
ManyToMany
si:dkey-108k21.21 34
  • 61 (a)
ManyToMany
Species where no ortholog for HIST1H1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1B Gene

ENSEMBL:
Gene Tree for HIST1H1B (if available)
TreeFam:
Gene Tree for HIST1H1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HIST1H1B: view image

Paralogs for HIST1H1B Gene

Paralogs for HIST1H1B Gene

(7) SIMAP similar genes for HIST1H1B Gene using alignment to 1 proteins:

  • H15_HUMAN
genes like me logo Genes that share paralogs with HIST1H1B: view

Variants for HIST1H1B Gene

Sequence variations from dbSNP and Humsavar for HIST1H1B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_036204 A colorectal cancer sample p.Gly86Asp
rs1000059765 -- 27,867,741(-) A/G upstream_transcript_variant
rs1001004719 -- 27,869,039(-) C/A upstream_transcript_variant
rs1002138254 -- 27,868,570(-) T/C upstream_transcript_variant
rs1002190688 -- 27,868,971(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1B Gene

Variant ID Type Subtype PubMed ID
nsv601208 CNV loss 21841781

Variation tolerance for HIST1H1B Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST1H1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1B Gene

Disorders for HIST1H1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIST1H1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
griscelli syndrome, type 1
  • gs1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HIST1H1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HIST1H1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIST1H1B Gene

Publications for HIST1H1B Gene

  1. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W … Doenecke D (Gene 1997) 2 3 4 22 58
  2. M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PMID: 19136008) Happel N … Doenecke D (Journal of molecular biology 2009) 3 4 22 58
  3. Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1. (PMID: 16377619) Sarg B … Lindner HH (The Journal of biological chemistry 2006) 3 4 22 58
  4. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for HIST1H1B Gene

Sources for HIST1H1B Gene

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