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Aliases for TBX21 Gene

Aliases for TBX21 Gene

  • T-Box 21 2 3 5
  • T-Cell-Specific T-Box Transcription Factor T-Bet 3 4
  • Transcription Factor TBLYM 3 4
  • T-Box Protein 21 3 4
  • TBLYM 3 4
  • TBET 3 4
  • T-Box Transcription Factor TBX21 3
  • T-Box Expressed In T Cells 3
  • T-PET 3
  • T-Bet 3

External Ids for TBX21 Gene

Previous GeneCards Identifiers for TBX21 Gene

  • GC17P045516
  • GC17P048291
  • GC17P046152
  • GC17P046285
  • GC17P043166
  • GC17P045810
  • GC17P041179

Summaries for TBX21 Gene

Entrez Gene Summary for TBX21 Gene

  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBX21 Gene

TBX21 (T-Box 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Nasal Polyps, And Aspirin Intolerance and Genital Herpes. Among its related pathways are Glucocorticoid receptor regulatory network and IL12 signaling mediated by STAT4. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot for TBX21 Gene

  • Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).

Gene Wiki entry for TBX21 Gene

Additional gene information for TBX21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBX21 Gene

Genomics for TBX21 Gene

GeneHancer (GH) Regulatory Elements for TBX21 Gene

Promoters and enhancers for TBX21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J047728 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 670.7 -0.2 -210 8.4 HDGF IRF4 GLIS2 ZNF143 ATF7 RUNX3 ZC3H11A GLIS1 NBN CTCF TBX21 TBKBP1 OSBPL7 SCRN2 EFCAB13 MRPL45P2 SP2 RPS2P47 KPNB1 ENSG00000264701
GH17J047700 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -28.3 -28258 9.3 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 CBX5 E2F8 ZNF263 MCM3 MRPL45P2 TBKBP1 SP2 EFCAB13 ENSG00000253347 ENSG00000264701 ENSG00000266601 RPS7P11 CDK5RAP3 RPS2P47
GH17J047719 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -13.5 -13529 1 HDGF BATF IRF4 ZNF366 FOS ETV6 IKZF2 RUNX3 CBFB JUNB TBKBP1 TBX21
GH17J048036 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4.3 +304.3 304337 1.8 HDGF PKNOX1 ARID4B SIN3A BMI1 THRB ZNF48 RAD21 ELK1 ZNF207 COPZ2 MIR152 GC17P048037 PRR15L ENSG00000263412 SNX11 SCRN2 TBX21
GH17J048001 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +270.2 270157 4.4 HDGF ARNT ZNF133 SIN3A YBX1 ZBTB7B IRF4 YY1 ZNF121 ZNF766 PRR15L CALCOCO2 SP2 PNPO SP2-AS1 HOXB4 ENSG00000266601 NFE2L1 SNX11 CBX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBX21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBX21 gene promoter:
  • AP-1
  • STAT1
  • c-Jun
  • ATF-2
  • c-Fos
  • STAT1alpha
  • STAT1beta

Genomic Locations for TBX21 Gene

Genomic Locations for TBX21 Gene
chr17:47,733,244-47,746,122
(GRCh38/hg38)
Size:
12,879 bases
Orientation:
Plus strand
chr17:45,810,610-45,823,485
(GRCh37/hg19)
Size:
12,876 bases
Orientation:
Plus strand

Genomic View for TBX21 Gene

Genes around TBX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBX21 Gene

Proteins for TBX21 Gene

  • Protein details for TBX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL17-TBX21_HUMAN
    Recommended name:
    T-box transcription factor TBX21
    Protein Accession:
    Q9UL17

    Protein attributes for TBX21 Gene

    Size:
    535 amino acids
    Molecular mass:
    58328 Da
    Quaternary structure:
    • Interacts with RUNX1, RUNX3, ITK, ABL1, RELA, CDK9 and KDM6B. The phosphorylated form (at Thr-303) interacts with NFATC2. Interacts with SMARCA4 in a KDM6B-dependent manner (By similarity). Interacts with CCTN1 (PubMed:27292648). Interacts with USP10 (PubMed:24845384). The phosphorylated form (at Tyr-530) interacts with GATA3 (PubMed:15662016).

neXtProt entry for TBX21 Gene

Post-translational modifications for TBX21 Gene

  • Phosphorylations at Ser-53, Tyr-77, Ser-225 and Ser-513 are regulated by mTORC1. Phosphorylation at Tyr-530 is essential for its interaction GATA3. Phosphorylation at Tyr-220, Tyr-266 and Tyr-305 enhances its transcriptional activator activity. Phosphorylation at Thr-303 is required for its interaction with NFATC2.
  • Ubiquitinated at Lys-314, leading to its degradation by the proteasome. Ubiquitination is essential for controlling protein stability, binding to the T-box-binding element of the IFN-gamma promoter, and for interaction with NFATC2 through induction of phosphorylation at Thr-303 (By similarity). Deubiquitinated by USP10 leading to its stabilization (PubMed:24845384).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TBX21 Gene

Domains & Families for TBX21 Gene

Gene Families for TBX21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TBX21 Gene

Suggested Antigen Peptide Sequences for TBX21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBX21: view

No data available for UniProtKB/Swiss-Prot for TBX21 Gene

Function for TBX21 Gene

Molecular function for TBX21 Gene

UniProtKB/Swiss-Prot Function:
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).

Phenotypes From GWAS Catalog for TBX21 Gene

Gene Ontology (GO) - Molecular Function for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 10761931
GO:0005515 protein binding IPI 15662016
genes like me logo Genes that share ontologies with TBX21: view
genes like me logo Genes that share phenotypes with TBX21: view

Human Phenotype Ontology for TBX21 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TBX21 Gene

MGI Knock Outs for TBX21:

Animal Model Products

CRISPR Products

miRNA for TBX21 Gene

miRTarBase miRNAs that target TBX21
Targeted motifs for TBX21 Gene
HOMER Transcription Factor Regulatory Elements motif TBX21
  • Consensus sequence: AGGTGTGAAM Submotif: canonical Cell Type: CD8 GEO ID: GSE33802

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBX21

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for TBX21 Gene

Localization for TBX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBX21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBX21 gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TBX21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TBX21 Gene

Pathways & Interactions for TBX21 Gene

genes like me logo Genes that share pathways with TBX21: view

Gene Ontology (GO) - Biological Process for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 18504404
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10761931
GO:0007275 multicellular organism development TAS 10761931
GO:0009615 response to virus IEP 20583921
genes like me logo Genes that share ontologies with TBX21: view

No data available for SIGNOR curated interactions for TBX21 Gene

Drugs & Compounds for TBX21 Gene

(1) Drugs for TBX21 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0
genes like me logo Genes that share compounds with TBX21: view

Transcripts for TBX21 Gene

mRNA/cDNA for TBX21 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBX21 Gene

T-box 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBX21

Alternative Splicing Database (ASD) splice patterns (SP) for TBX21 Gene

No ASD Table

Relevant External Links for TBX21 Gene

GeneLoc Exon Structure for
TBX21
ECgene alternative splicing isoforms for
TBX21

Expression for TBX21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBX21 Gene

This gene is overexpressed in Whole Blood (x26.5) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for TBX21 Gene

This gene is overexpressed in NK cells (22.8), Peripheral blood mononuclear cells (15.3), Brain (15.0), and CD8 Tcells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBX21 Gene



Protein tissue co-expression partners for TBX21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBX21 Gene:

TBX21

SOURCE GeneReport for Unigene cluster for TBX21 Gene:

Hs.272409

mRNA Expression by UniProt/SwissProt for TBX21 Gene:

Q9UL17-TBX21_HUMAN
Tissue specificity: T-cell specific.

Evidence on tissue expression from TISSUES for TBX21 Gene

  • Blood(3.6)
  • Spleen(3.2)
  • Lymph node(2.8)
  • Lung(2.3)
  • Bone marrow(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TBX21 Gene

Germ Layers:
  • ectoderm
  • endoderm
Systems:
  • immune
  • respiratory
Regions:
Head and neck:
  • head
  • mouth
  • nose
  • pharynx
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TBX21: view

Orthologs for TBX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBX21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBX21 34 33
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TBX21 34 33
  • 90.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TBX21 34 33
  • 89.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tbx21 16 34 33
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Tbx21 33
  • 85.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TBX21 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TBX21 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tbx21 34
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbx-9 34 35
  • 28 (a)
ManyToMany
tbx-37 34
  • 27 (a)
ManyToMany
tbx-11 34
  • 26 (a)
ManyToMany
tbx-8 34 35
  • 26 (a)
ManyToMany
tbx-43 34
  • 25 (a)
ManyToMany
tbx-38 34
  • 24 (a)
ManyToMany
tbx-34 34
  • 20 (a)
ManyToMany
tbx-42 34
  • 19 (a)
ManyToMany
tbx-30 34
  • 19 (a)
ManyToMany
tbx-35 34
  • 19 (a)
ManyToMany
tbx-40 34
  • 15 (a)
ManyToMany
tbx-39 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7001 34
  • 15 (a)
OneToMany
Species where no ortholog for TBX21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBX21 Gene

ENSEMBL:
Gene Tree for TBX21 (if available)
TreeFam:
Gene Tree for TBX21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBX21: view image

Paralogs for TBX21 Gene

Paralogs for TBX21 Gene

(4) SIMAP similar genes for TBX21 Gene using alignment to 1 proteins:

  • TBX21_HUMAN
genes like me logo Genes that share paralogs with TBX21: view

Variants for TBX21 Gene

Sequence variations from dbSNP and Humsavar for TBX21 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000631219 -- 47,746,614(+) G/C downstream_transcript_variant
rs1001075810 -- 47,746,326(+) C/T downstream_transcript_variant
rs1001193365 -- 47,745,907(+) T/G 3_prime_UTR_variant
rs1001312189 -- 47,735,783(+) A/C intron_variant
rs1001331350 -- 47,733,293(+) GGG/GGGG 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TBX21 Gene

Variant ID Type Subtype PubMed ID
nsv1116224 CNV deletion 24896259
nsv2071 CNV deletion 18451855
nsv507841 OTHER sequence alteration 20534489

Variation tolerance for TBX21 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBX21 Gene

Human Gene Mutation Database (HGMD)
TBX21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBX21

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBX21 Gene

Disorders for TBX21 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TBX21 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma, nasal polyps, and aspirin intolerance
  • asa triad
genital herpes
  • genital herpes simplex
acute necrotizing encephalitis
  • encephalitis, acute necrotizing
spongiotic dermatitis
heart sarcoma
  • cardiac sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search TBX21 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBX21_HUMAN
  • Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. {ECO:0000269 PubMed:15806396}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for TBX21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TBX21: view

No data available for Genatlas for TBX21 Gene

Publications for TBX21 Gene

  1. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PMID: 15806396) Akahoshi M … Shirakawa T (Human genetics 2005) 3 4 22 44 58
  2. Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. (PMID: 20429676) You Y … Deng G (Scandinavian journal of rheumatology 2010) 3 22 44 58
  3. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PMID: 19287198) Chae SC … Chung HT (Experimental & molecular medicine 2009) 3 22 44 58
  4. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PMID: 19362357) Suttner K … Kabesch M (The Journal of allergy and clinical immunology 2009) 3 22 44 58
  5. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (PMID: 17949803) Munthe-Kaas MC … Undlien D (The Journal of allergy and clinical immunology 2008) 3 22 44 58

Products for TBX21 Gene

Sources for TBX21 Gene

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