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Aliases for PILRB Gene

Aliases for PILRB Gene

  • Paired Immunoglobin-Like Type 2 Receptor Beta 2 3 5
  • Activating Receptor PILR-Beta 3 4
  • Cell Surface Receptor FDFACT 3 4
  • Paired Immunoglobulin-Like Type 2 Receptor Beta 3
  • Paired Immunoglobulin-Like Receptor Beta 3
  • Paired Immunoglobin-Like Receptor Beta 3
  • Cell Surface Receptor FDFACT1 3
  • Cell Surface Receptor FDFACT2 3
  • Activating Receptor PILRbeta 3
  • FDFACT1 3
  • FDFACT2 3
  • FDFACT 4

External Ids for PILRB Gene

Previous GeneCards Identifiers for PILRB Gene

  • GC07P099546
  • GC07P099545
  • GC07P099578
  • GC07P099771
  • GC07P099936
  • GC07P099938
  • GC07P094588
  • GC07P099940
  • GC07P099945

Summaries for PILRB Gene

Entrez Gene Summary for PILRB Gene

  • The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]

GeneCards Summary for PILRB Gene

PILRB (Paired Immunoglobin-Like Type 2 Receptor Beta) is a Protein Coding gene. An important paralog of this gene is PILRA.

UniProtKB/Swiss-Prot for PILRB Gene

  • Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Gene Wiki entry for PILRB Gene

Additional gene information for PILRB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PILRB Gene

Genomics for PILRB Gene

GeneHancer (GH) Regulatory Elements for PILRB Gene

Promoters and enhancers for PILRB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100335 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.4 -16.1 -16075 2.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B STAG3L5P STAG3L5P-PVRIG2P-PILRB PILRB PILRA ZSCAN25 ZNF3 ZNF655 TRIM4 GIGYF1 PCOLCE
GH07J100351 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 665 3.1 PTBP1 EBF1 ZFHX2 ZNF366 POLR2A SCRT2 RBM22 ATF7 IKZF2 RUNX3 PILRB PVRIG2P PILRA MBLAC1 AP4M1 CNPY4 STAG3 PVRIG MIR6840 STAG3L5P
GH07J100358 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 650.4 +5.9 5925 0.2 RBM22 MIR6840 PILRB PIR35775 STAG3L5P-PVRIG2P-PILRB GC07M100182
GH07J100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 56 +125.6 125579 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF655 ZNF3 ENSG00000242798 STAG3L5P PPP1R35
GH07J099471 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 51.1 -879.6 -879572 3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ZNF789 ZSCAN25 PPP1R35 PTCD1 TRRAP MEPCE TRIM4 STAG3L5P ZNF655 AP4M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PILRB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PILRB gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • MAZR
  • C/EBPbeta
  • RelA
  • FAC1
  • GR
  • GR-alpha
  • GR-beta
  • E2F-1

Genomic Locations for PILRB Gene

Genomic Locations for PILRB Gene
chr7:100,352,176-100,367,831
(GRCh38/hg38)
Size:
15,656 bases
Orientation:
Plus strand
chr7:99,933,688-99,965,454
(GRCh37/hg19)
Size:
31,767 bases
Orientation:
Plus strand

Genomic View for PILRB Gene

Genes around PILRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PILRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PILRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PILRB Gene

Proteins for PILRB Gene

  • Protein details for PILRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKJ0-PILRB_HUMAN
    Recommended name:
    Paired immunoglobulin-like type 2 receptor beta
    Protein Accession:
    Q9UKJ0
    Secondary Accessions:
    • Q69YF9
    • Q9HBS0

    Protein attributes for PILRB Gene

    Size:
    227 amino acids
    Molecular mass:
    25542 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PILRB Gene

    Alternative splice isoforms for PILRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PILRB Gene

Post-translational modifications for PILRB Gene

  • Glycosylation at isoforms=100
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PILRB Gene

Domains & Families for PILRB Gene

Gene Families for PILRB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PILRB Gene

Suggested Antigen Peptide Sequences for PILRB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PILRB: view

No data available for UniProtKB/Swiss-Prot for PILRB Gene

Function for PILRB Gene

Molecular function for PILRB Gene

UniProtKB/Swiss-Prot Function:
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Phenotypes From GWAS Catalog for PILRB Gene

Gene Ontology (GO) - Molecular Function for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10660620
GO:0042288 MHC class I protein binding IBA --
genes like me logo Genes that share ontologies with PILRB: view

Phenotypes for PILRB Gene

genes like me logo Genes that share phenotypes with PILRB: view

Animal Model Products

CRISPR Products

miRNA for PILRB Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PILRB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PILRB Gene

Localization for PILRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PILRB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PILRB gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
extracellular 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10660620
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PILRB: view

Pathways & Interactions for PILRB Gene

SuperPathways for PILRB Gene

No Data Available

Interacting Proteins for PILRB Gene

Gene Ontology (GO) - Biological Process for PILRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 10660620
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity NAS 10660620
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with PILRB: view

No data available for Pathways by source and SIGNOR curated interactions for PILRB Gene

Drugs & Compounds for PILRB Gene

No Compound Related Data Available

Transcripts for PILRB Gene

mRNA/cDNA for PILRB Gene

Unigene Clusters for PILRB Gene

Paired immunoglobin-like type 2 receptor beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PILRB

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PILRB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -
SP7: - -

Relevant External Links for PILRB Gene

GeneLoc Exon Structure for
PILRB
ECgene alternative splicing isoforms for
PILRB

Expression for PILRB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PILRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PILRB Gene:

PILRB

SOURCE GeneReport for Unigene cluster for PILRB Gene:

Hs.632314

Evidence on tissue expression from TISSUES for PILRB Gene

  • Blood(4.1)
genes like me logo Genes that share expression patterns with PILRB: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PILRB Gene

Orthologs for PILRB Gene

This gene was present in the common ancestor of mammals.

Orthologs for PILRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PILRB 34 33
  • 97.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Pilrb1 34 33
  • 65.2 (n)
ManyToMany
Pilrb2 16 34
  • 40 (a)
Pilra 34
  • 31 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100910801 33
  • 65.13 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 37 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 34 (a)
ManyToMany
PILRA 34
  • 32 (a)
ManyToMany
Species where no ortholog for PILRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PILRB Gene

ENSEMBL:
Gene Tree for PILRB (if available)
TreeFam:
Gene Tree for PILRB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PILRB: view image

Paralogs for PILRB Gene

Paralogs for PILRB Gene

(1) SIMAP similar genes for PILRB Gene using alignment to 8 proteins:

  • PILRB_HUMAN
  • C9J8P3_HUMAN
  • C9JGQ4_HUMAN
  • C9JNA4_HUMAN
  • C9JPU0_HUMAN
  • C9JTD2_HUMAN
  • L8EAS8_HUMAN
  • V9GYC2_HUMAN

Pseudogenes.org Pseudogenes for PILRB Gene

genes like me logo Genes that share paralogs with PILRB: view

Variants for PILRB Gene

Sequence variations from dbSNP and Humsavar for PILRB Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000169297 -- 100,365,958(+) T/G intron_variant
rs1000224503 -- 100,359,955(+) A/G intron_variant
rs1000574546 -- 100,356,490(+) G/T upstream_transcript_variant
rs1000629134 -- 100,361,631(+) T/A intron_variant
rs1000924444 -- 100,356,697(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PILRB Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
esv2734891 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv831071 CNV loss 17160897

Variation tolerance for PILRB Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PILRB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PILRB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PILRB Gene

Disorders for PILRB Gene

Additional Disease Information for PILRB

No disorders were found for PILRB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PILRB Gene

Publications for PILRB Gene

  1. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. (PMID: 10660620) Mousseau DD … Shen SH (The Journal of biological chemistry 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for PILRB Gene

Sources for PILRB Gene

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