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Aliases for SLC39A3 Gene

Aliases for SLC39A3 Gene

  • Solute Carrier Family 39 Member 3 2 3 4 5
  • Solute Carrier Family 39 (Zinc Transporter), Member 3 2 3
  • Zrt- And Irt-Like Protein 3 3 4
  • ZIP-3 3 4
  • ZIP3 3 4
  • Zinc Transporter ZIP3 3

External Ids for SLC39A3 Gene

Previous GeneCards Identifiers for SLC39A3 Gene

  • GC19M002795
  • GC19M002672
  • GC19M002683
  • GC19M002502

Summaries for SLC39A3 Gene

GeneCards Summary for SLC39A3 Gene

SLC39A3 (Solute Carrier Family 39 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A1.

UniProtKB/Swiss-Prot for SLC39A3 Gene

  • Acts as a zinc-influx transporter.

Gene Wiki entry for SLC39A3 Gene

Additional gene information for SLC39A3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A3 Gene

Genomics for SLC39A3 Gene

GeneHancer (GH) Regulatory Elements for SLC39A3 Gene

Promoters and enhancers for SLC39A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I002738 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.7 +0.6 625 2.4 MLX ZFP64 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SLC39A3 ENSG00000267001 GC19P002738 SF3A2 LOC100288123 ZNF77 CACTIN-AS1 DOT1L ZNF555 CACTIN
GH19I003363 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 -627.6 -627585 8.1 HDGF SMAD1 ARNT YBX1 ZNF2 YY1 POLR2B ZNF213 ZNF143 ZNF263 NFIC CACTIN-AS1 CACTIN ZNF77 LMNB2 CCDC94 APBA3 PIAS4 ENSG00000267139 ZNF555
GH19I003605 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.4 -867.5 -867451 4.6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF766 SP3 MCM5 CACTIN-AS1 TBXA2R ZNF77 CACTIN CCDC94 ENSG00000267030 ZNF555 ENSG00000267769 APBA3 GNA11
GH19I003150 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -413.2 -413236 6 HDGF PKNOX1 SMAD1 FOXA2 ARNT YBX1 IRF4 POLR2B ZNF766 E2F8 PIR47090 LOC100996351 GC19P003154 GC19P003153 ZNF77 CACTIN GNA11 DOT1L ZNF555 LMNB2
GH19I001745 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +991.7 991701 5.8 HDGF PKNOX1 ARNT ZNF2 YY1 POLR2B ZNF766 CBX5 ZNF143 FOS ENSG00000267073 CIRBP SPPL2B AP3D1 SCAMP4 MUM1 SLC39A3 C19orf24 ATP8B3 REXO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC39A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC39A3 gene promoter:

Genomic Locations for SLC39A3 Gene

Genomic Locations for SLC39A3 Gene
chr19:2,732,204-2,740,152
(GRCh38/hg38)
Size:
7,949 bases
Orientation:
Minus strand
chr19:2,732,202-2,740,150
(GRCh37/hg19)

Genomic View for SLC39A3 Gene

Genes around SLC39A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A3 Gene

Proteins for SLC39A3 Gene

  • Protein details for SLC39A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRY0-S39A3_HUMAN
    Recommended name:
    Zinc transporter ZIP3
    Protein Accession:
    Q9BRY0
    Secondary Accessions:
    • B3KMJ3
    • Q8WUG1

    Protein attributes for SLC39A3 Gene

    Size:
    314 amino acids
    Molecular mass:
    33601 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A3 Gene

Post-translational modifications for SLC39A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC39A3 Gene

No data available for DME Specific Peptides for SLC39A3 Gene

Domains & Families for SLC39A3 Gene

Gene Families for SLC39A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC39A3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRY0

UniProtKB/Swiss-Prot:

S39A3_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A3: view

Function for SLC39A3 Gene

Molecular function for SLC39A3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a zinc-influx transporter.

Phenotypes From GWAS Catalog for SLC39A3 Gene

Gene Ontology (GO) - Molecular Function for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS --
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A3: view
genes like me logo Genes that share phenotypes with SLC39A3: view

Animal Models for SLC39A3 Gene

MGI Knock Outs for SLC39A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A3

miRNA for SLC39A3 Gene

miRTarBase miRNAs that target SLC39A3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A3 Gene

Localization for SLC39A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A3 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A3: view

Pathways & Interactions for SLC39A3 Gene

genes like me logo Genes that share pathways with SLC39A3: view

Gene Ontology (GO) - Biological Process for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
genes like me logo Genes that share ontologies with SLC39A3: view

No data available for SIGNOR curated interactions for SLC39A3 Gene

Drugs & Compounds for SLC39A3 Gene

(1) Drugs for SLC39A3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC39A3: view

Transcripts for SLC39A3 Gene

Unigene Clusters for SLC39A3 Gene

Solute carrier family 39 (zinc transporter), member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A3 Gene

No ASD Table

Relevant External Links for SLC39A3 Gene

GeneLoc Exon Structure for
SLC39A3
ECgene alternative splicing isoforms for
SLC39A3

Expression for SLC39A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A3 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for SLC39A3 Gene

This gene is overexpressed in Ovary (47.7), Testis (14.0), and Platelet (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A3 Gene



Protein tissue co-expression partners for SLC39A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC39A3 Gene:

SLC39A3

SOURCE GeneReport for Unigene cluster for SLC39A3 Gene:

Hs.515046

Evidence on tissue expression from TISSUES for SLC39A3 Gene

  • Intestine(4.2)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with SLC39A3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A3 Gene

Orthologs for SLC39A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A3 33 34
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia SLC39A3 33 34
  • 89.38 (n)
cow
(Bos Taurus)
Mammalia SLC39A3 33 34
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Slc39a3 33 16 34
  • 81.74 (n)
rat
(Rattus norvegicus)
Mammalia Slc39a3 33
  • 81.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC39A3 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A3 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A3 33 34
  • 76.78 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a3 33
  • 62.83 (n)
Str.17341 33
fruit fly
(Drosophila melanogaster)
Insecta Zip3 33 34
  • 49.83 (n)
ZIP1 34
  • 26 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011178 33
  • 46.38 (n)
worm
(Caenorhabditis elegans)
Secernentea C18A3.2 34
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for SLC39A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC39A3 Gene

ENSEMBL:
Gene Tree for SLC39A3 (if available)
TreeFam:
Gene Tree for SLC39A3 (if available)

Paralogs for SLC39A3 Gene

Paralogs for SLC39A3 Gene

(2) SIMAP similar genes for SLC39A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC39A3: view

Variants for SLC39A3 Gene

Sequence variations from dbSNP and Humsavar for SLC39A3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000349816 -- 2,734,961(-) G/A 3_prime_UTR_variant, intron_variant
rs1000602627 -- 2,735,692(-) G/T 3_prime_UTR_variant, intron_variant
rs1000777222 -- 2,732,114(-) C/T downstream_transcript_variant
rs1000806149 -- 2,740,411(-) T/A upstream_transcript_variant
rs1000852306 -- 2,732,105(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A3 Gene

Variant ID Type Subtype PubMed ID
esv3643437 CNV gain 21293372
nsv509714 CNV insertion 20534489
nsv828397 CNV gain 20364138

Variation tolerance for SLC39A3 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC39A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC39A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A3 Gene

Disorders for SLC39A3 Gene

Additional Disease Information for SLC39A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC39A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A3 Gene

Publications for SLC39A3 Gene

  1. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PMID: 19308021) Ollila HM … Paunio T (Molecular psychiatry 2009) 3 44 58
  2. hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. (PMID: 17550612) Desouki MM … Costello LC (Molecular cancer 2007) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. (PMID: 14525987) Dufner-Beattie J … Andrews GK (The Journal of biological chemistry 2003) 3 22 58
  5. Functional expression of the human hZIP2 zinc transporter. (PMID: 10681536) Gaither LA … Eide DJ (The Journal of biological chemistry 2000) 2 3 58

Products for SLC39A3 Gene

Sources for SLC39A3 Gene

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