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Aliases for STRN3 Gene

Aliases for STRN3 Gene

  • Striatin 3 2 3 5
  • Protein Phosphatase 2 Regulatory Subunit Bbeta 2 3
  • Striatin, Calmodulin Binding Protein 3 2 3
  • Cell Cycle S/G2 Nuclear Autoantigen 2 3
  • Cell Cycle Autoantigen SG2NA 3 4
  • S/G2 Antigen 3 4
  • SG2NA 3 4
  • Nuclear Autoantigen 3
  • Striatin-3 3
  • PPP2R6B 3
  • S/G2NA 3
  • GS2NA 4

External Ids for STRN3 Gene

Previous GeneCards Identifiers for STRN3 Gene

  • GC14M028738
  • GC14M025150
  • GC14M029353
  • GC14M030432
  • GC14M031363
  • GC14M011480

Summaries for STRN3 Gene

GeneCards Summary for STRN3 Gene

STRN3 (Striatin 3) is a Protein Coding gene. Among its related pathways are Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and calmodulin binding. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot for STRN3 Gene

  • Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Gene Wiki entry for STRN3 Gene

Additional gene information for STRN3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRN3 Gene

Genomics for STRN3 Gene

GeneHancer (GH) Regulatory Elements for STRN3 Gene

Promoters and enhancers for STRN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J031023 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658 +0.8 799 4.7 CLOCK MLX YBX1 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 STRN3 AP4S1 RPL21P5 G2E3 SCFD1
GH14J031056 Enhancer 1.2 Ensembl ENCODE 18.8 -32.6 -32630 4.7 PKNOX1 SMAD1 ARNT YY1 ZNF766 MCM3 REST ZNF592 KAT8 MEF2D STRN3 AP4S1 MIR624 HEATR5A RPL21P5
GH14J030994 Enhancer 1 Ensembl ENCODE 19.4 +29.8 29811 5.1 PKNOX1 BMI1 FEZF1 BATF DNMT3B ZNF121 IKZF2 RUNX3 JUNB NR2F2 STRN3 AP4S1 RNU6-541P DTD2 MIR624 HIGD1AP17
GH14J031030 Enhancer 1.2 Ensembl ENCODE 9.6 -6.0 -5955 4.2 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 YY1 SLC30A9 FOS STRN3 AP4S1 RPL21P5
GH14J030980 Enhancer 1.1 Ensembl ENCODE 8.4 +46.1 46127 0.8 ARID4B SIN3A ZNF48 RAD21 RFX5 ARID2 EGR1 ZNF143 THAP11 MIXL1 MIR624 AP4S1 RNU6-541P STRN3 HIGD1AP17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STRN3 gene promoter:
  • deltaCREB
  • CREB
  • Chx10
  • E47
  • Meis-1b
  • Meis-1a
  • Meis-1
  • Lmo2
  • Cdc5
  • AhR

Genomic Locations for STRN3 Gene

Genomic Locations for STRN3 Gene
chr14:30,893,779-31,026,528
(GRCh38/hg38)
Size:
132,750 bases
Orientation:
Minus strand
chr14:31,363,005-31,495,607
(GRCh37/hg19)
Size:
132,603 bases
Orientation:
Minus strand

Genomic View for STRN3 Gene

Genes around STRN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRN3 Gene

Proteins for STRN3 Gene

  • Protein details for STRN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13033-STRN3_HUMAN
    Recommended name:
    Striatin-3
    Protein Accession:
    Q13033
    Secondary Accessions:
    • A2RTX7
    • A6NHZ7
    • Q9NRA5

    Protein attributes for STRN3 Gene

    Size:
    797 amino acids
    Molecular mass:
    87209 Da
    Quaternary structure:
    • Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB (PubMed:25743393).

    Three dimensional structures from OCA and Proteopedia for STRN3 Gene

    Alternative splice isoforms for STRN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STRN3 Gene

Post-translational modifications for STRN3 Gene

  • Ubiquitination at isoforms=2173
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STRN3 Gene

Domains & Families for STRN3 Gene

Gene Families for STRN3 Gene

Suggested Antigen Peptide Sequences for STRN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13033

UniProtKB/Swiss-Prot:

STRN3_HUMAN :
  • Belongs to the WD repeat striatin family.
Family:
  • Belongs to the WD repeat striatin family.
genes like me logo Genes that share domains with STRN3: view

Function for STRN3 Gene

Molecular function for STRN3 Gene

UniProtKB/Swiss-Prot Function:
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Phenotypes From GWAS Catalog for STRN3 Gene

Gene Ontology (GO) - Molecular Function for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
GO:0005516 calmodulin binding NAS 10748158
GO:0017048 Rho GTPase binding IPI 25743393
GO:0044877 protein-containing complex binding IDA 18782753
GO:0051721 protein phosphatase 2A binding IDA 18782753
genes like me logo Genes that share ontologies with STRN3: view
genes like me logo Genes that share phenotypes with STRN3: view

Animal Models for STRN3 Gene

MGI Knock Outs for STRN3:
  • Strn3 Strn3<tm1b(KOMP)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STRN3 Gene

Localization for STRN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRN3 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRN3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
golgi apparatus 5
cytosol 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 colocalizes_with protein phosphatase type 2A complex IDA 18782753
GO:0005654 nucleoplasm IDA 11570823
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA 11251078
GO:0005886 plasma membrane IDA 11251078
genes like me logo Genes that share ontologies with STRN3: view

Pathways & Interactions for STRN3 Gene

genes like me logo Genes that share pathways with STRN3: view

Pathways by source for STRN3 Gene

Gene Ontology (GO) - Biological Process for STRN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032355 response to estradiol ISS,IEA --
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway ISS,IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with STRN3: view

No data available for SIGNOR curated interactions for STRN3 Gene

Drugs & Compounds for STRN3 Gene

(1) Drugs for STRN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with STRN3: view

Transcripts for STRN3 Gene

Unigene Clusters for STRN3 Gene

Striatin, calmodulin binding protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: - - -

Relevant External Links for STRN3 Gene

GeneLoc Exon Structure for
STRN3
ECgene alternative splicing isoforms for
STRN3

Expression for STRN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STRN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRN3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for STRN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.7) and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for STRN3 Gene



Protein tissue co-expression partners for STRN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STRN3 Gene:

STRN3

SOURCE GeneReport for Unigene cluster for STRN3 Gene:

Hs.401843

Evidence on tissue expression from TISSUES for STRN3 Gene

  • Nervous system(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with STRN3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRN3 Gene

Orthologs for STRN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STRN3 34 33
  • 99.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia STRN3 34 33
  • 95.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia STRN3 34 33
  • 95.07 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STRN3 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia STRN3 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Strn3 16 34 33
  • 92.67 (n)
rat
(Rattus norvegicus)
Mammalia Strn3 33
  • 92.54 (n)
chicken
(Gallus gallus)
Aves STRN3 34 33
  • 89.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STRN3 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii strn3 34 33 33
  • 72.21 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9790 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008755 33
  • 57.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cka 33
  • 56.51 (n)
worm
(Caenorhabditis elegans)
Secernentea cash-1 33
  • 54.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 34
  • 10 (a)
OneToMany
FAR8 36
sea squirt
(Ciona savignyi)
Ascidiacea Cin.3348 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3348 33
Species where no ortholog for STRN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for STRN3 Gene

ENSEMBL:
Gene Tree for STRN3 (if available)
TreeFam:
Gene Tree for STRN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for STRN3: view image

Paralogs for STRN3 Gene

Paralogs for STRN3 Gene

(4) SIMAP similar genes for STRN3 Gene using alignment to 6 proteins:

  • STRN3_HUMAN
  • A0AV58_HUMAN
  • G3V340_HUMAN
  • G3V3G7_HUMAN
  • H0YJT2_HUMAN
  • H0YJZ4_HUMAN
genes like me logo Genes that share paralogs with STRN3: view

Variants for STRN3 Gene

Sequence variations from dbSNP and Humsavar for STRN3 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs78648016 benign, not specified 31,025,782(-) G/A intron_variant
rs1000023802 -- 30,908,162(-) T/C intron_variant
rs1000029579 -- 30,989,442(-) C/T intron_variant
rs1000031470 -- 31,027,427(-) C/T upstream_transcript_variant
rs1000058163 -- 30,907,873(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STRN3 Gene

Variant ID Type Subtype PubMed ID
dgv3605n54 CNV loss 21841781
dgv3606n54 CNV loss 21841781
esv2659815 CNV deletion 23128226
esv33189 CNV loss 17666407
esv3633963 CNV loss 21293372
esv3892495 CNV gain 25118596
nsv1049063 CNV gain 25217958
nsv1141768 CNV insertion 24896259
nsv1231 CNV deletion 18451855
nsv1233 CNV insertion 18451855
nsv456197 CNV loss 19166990
nsv564169 CNV gain 21841781
nsv832762 CNV loss 17160897
nsv85534 CNV deletion 16902084

Variation tolerance for STRN3 Gene

Residual Variation Intolerance Score: 4.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.93; 96.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STRN3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRN3 Gene

Disorders for STRN3 Gene

Additional Disease Information for STRN3

No disorders were found for STRN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRN3 Gene

Publications for STRN3 Gene

  1. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. (PMID: 7864889) Muro Y … Tan EM (Biochemical and biophysical research communications 1995) 2 3 4 22 58
  2. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. (PMID: 25743393) Lant B … Derry WB (Nature communications 2015) 3 4 58
  3. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. (PMID: 18434427) Tan B … Bigsby RM (Journal of molecular endocrinology 2008) 3 22 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (PMID: 10681496) Moreno CS … Pallas DC (The Journal of biological chemistry 2000) 2 3 58

Products for STRN3 Gene

Sources for STRN3 Gene

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