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Aliases for SAC3D1 Gene

Aliases for SAC3D1 Gene

  • SAC3 Domain Containing 1 2 3 5
  • SAC3 Homology Domain-Containing Protein 1 3 4
  • SHD1 3 4
  • SAC3 Domain-Containing Protein 1 3
  • Sac3 Homology Domain 1 3
  • HSU79266 3

External Ids for SAC3D1 Gene

Previous GeneCards Identifiers for SAC3D1 Gene

  • GC11P064566
  • GC11P064808
  • GC11P061135

Summaries for SAC3D1 Gene

GeneCards Summary for SAC3D1 Gene

SAC3D1 (SAC3 Domain Containing 1) is a Protein Coding gene. Diseases associated with SAC3D1 include Colonic Benign Neoplasm. An important paralog of this gene is MCM3AP.

UniProtKB/Swiss-Prot for SAC3D1 Gene

  • Involved in centrosome duplication and mitotic progression.

Gene Wiki entry for SAC3D1 Gene

Additional gene information for SAC3D1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAC3D1 Gene

Genomics for SAC3D1 Gene

GeneHancer (GH) Regulatory Elements for SAC3D1 Gene

Promoters and enhancers for SAC3D1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065040 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.6 +0.2 249 2.1 HDGF CLOCK MLX ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 DEK SAC3D1 KAT5 MUS81 SF1 DPF2 POLA2 SART1 RNASEH2C ZFPL1 PCNX3
GH11J065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 21.3 +383.3 383280 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065538 SF1 LOC105369352 ZFPL1 POLA2 EIF1AD
GH11J065115 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 19.7 +76.5 76463 3.5 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ENSG00000255173 ENSG00000278952 ZNHIT2 KAT5 LOC105369342 SF3B2 ZFPL1 DPF2 SAC3D1 RPS16P6
GH11J065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11 +449.2 449183 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 POLA2 PCNX3 ZFPL1 EIF1AD SART1 LOC105369352 MUS81 KAT5
GH11J065718 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.1 +678.9 678925 3.2 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 RNASEH2C SF1 PCNX3 RBM4 SART1 ENSG00000255320 POLA2 KAT5 EIF1AD ENSG00000258297
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAC3D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAC3D1 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • Meis-1
  • Evi-1
  • Meis-1a
  • Meis-1b
  • Brachyury

Genomic Locations for SAC3D1 Gene

Genomic Locations for SAC3D1 Gene
3,928 bases
Plus strand
3,928 bases
Plus strand

Genomic View for SAC3D1 Gene

Genes around SAC3D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAC3D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAC3D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAC3D1 Gene

Proteins for SAC3D1 Gene

  • Protein details for SAC3D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SAC3 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8MX08
    • Q99773

    Protein attributes for SAC3D1 Gene

    404 amino acids
    Molecular mass:
    43553 Da
    Quaternary structure:
    • May be part of a SEM1-containing complex.
    • Sequence=AP003068; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAC3D1 Gene


neXtProt entry for SAC3D1 Gene

Post-translational modifications for SAC3D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAC3D1 Gene

No data available for DME Specific Peptides for SAC3D1 Gene

Domains & Families for SAC3D1 Gene

Gene Families for SAC3D1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAC3D1 Gene


Suggested Antigen Peptide Sequences for SAC3D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAC3 family.
  • Belongs to the SAC3 family.
genes like me logo Genes that share domains with SAC3D1: view

Function for SAC3D1 Gene

Molecular function for SAC3D1 Gene

UniProtKB/Swiss-Prot Function:
Involved in centrosome duplication and mitotic progression.

Phenotypes From GWAS Catalog for SAC3D1 Gene

Gene Ontology (GO) - Molecular Function for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with SAC3D1: view
genes like me logo Genes that share phenotypes with SAC3D1: view

Animal Models for SAC3D1 Gene

MGI Knock Outs for SAC3D1:

Animal Model Products

miRNA for SAC3D1 Gene

miRTarBase miRNAs that target SAC3D1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SAC3D1 Gene

Localization for SAC3D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAC3D1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes on centrosomes in interphase cells and at spindles in mitosis. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAC3D1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with SAC3D1: view

Pathways & Interactions for SAC3D1 Gene

SuperPathways for SAC3D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAC3D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SAC3D1: view

No data available for Pathways by source and SIGNOR curated interactions for SAC3D1 Gene

Drugs & Compounds for SAC3D1 Gene

No Compound Related Data Available

Transcripts for SAC3D1 Gene

mRNA/cDNA for SAC3D1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAC3D1 Gene

SAC3 domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAC3D1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SAC3D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAC3D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAC3D1 Gene

mRNA differential expression in normal tissues according to GTEx for SAC3D1 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for SAC3D1 Gene

This gene is overexpressed in Breast (55.0) and Bone (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAC3D1 Gene

Protein tissue co-expression partners for SAC3D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAC3D1 Gene:


SOURCE GeneReport for Unigene cluster for SAC3D1 Gene:


Evidence on tissue expression from TISSUES for SAC3D1 Gene

  • Nervous system(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with SAC3D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAC3D1 Gene

Orthologs for SAC3D1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SAC3D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAC3D1 34 33
  • 98.42 (n)
(Canis familiaris)
Mammalia SAC3D1 34 33
  • 84.64 (n)
(Bos Taurus)
Mammalia SAC3D1 34 33
  • 83.33 (n)
(Mus musculus)
Mammalia Sac3d1 16 34 33
  • 78.59 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 10 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 5 (a)
(Anolis carolinensis)
Reptilia SAC3D1 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489268 33
  • 51.14 (n)
(Danio rerio)
Actinopterygii si:zfos-452g4.1 33
  • 51.21 (n)
SAC3D1 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3437 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tag-115 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC3 34
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for SAC3D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAC3D1 Gene

Gene Tree for SAC3D1 (if available)
Gene Tree for SAC3D1 (if available)
Evolutionary constrained regions (ECRs) for SAC3D1: view image

Paralogs for SAC3D1 Gene

Paralogs for SAC3D1 Gene

genes like me logo Genes that share paralogs with SAC3D1: view

Variants for SAC3D1 Gene

Sequence variations from dbSNP and Humsavar for SAC3D1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000145233 -- 65,040,295(+) G/A upstream_transcript_variant
rs1000788110 -- 65,041,586(+) C/T coding_sequence_variant, synonymous_variant
rs1001143077 -- 65,038,910(+) C/A upstream_transcript_variant
rs1001296983 -- 65,039,539(+) T/C/G upstream_transcript_variant
rs1001328180 -- 65,038,981(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SAC3D1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for SAC3D1 Gene

Gene Damage Index Score: 10.20; 90.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAC3D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAC3D1 Gene

Disorders for SAC3D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAC3D1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SAC3D1

genes like me logo Genes that share disorders with SAC3D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAC3D1 Gene

Publications for SAC3D1 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 4 58
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 3 4 58
  3. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. (PMID: 15322101) Khuda SE … Sakaguchi N (The Journal of biological chemistry 2004) 3 22 58
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SAC3D1 Gene

Sources for SAC3D1 Gene

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