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Aliases for GTF3C1 Gene

Aliases for GTF3C1 Gene

  • General Transcription Factor IIIC Subunit 1 2 3 5
  • General Transcription Factor IIIC, Polypeptide 1, Alpha 220kDa 2 3
  • Transcription Factor IIIC 220 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Alpha 3 4
  • TFIIIC Box B-Binding Subunit 3 4
  • TFIIIC 220 KDa Subunit 3 4
  • TF3C-Alpha 3 4
  • TFIIIC220 3 4
  • General Transcription Factor IIIC, Polypeptide 1 (Alpha Subunit, 220kD ) 2
  • General Transcription Factor IIIC, Polypeptide 1 (Alpha Subunit) 3
  • General Transcription Factor 3C Polypeptide 1 3
  • TFIIICalpha 3
  • TFIIIC 3

External Ids for GTF3C1 Gene

Previous GeneCards Identifiers for GTF3C1 Gene

  • GC16M026900
  • GC16M027570
  • GC16M027399
  • GC16M027438
  • GC16M027379
  • GC16M025560

Summaries for GTF3C1 Gene

GeneCards Summary for GTF3C1 Gene

GTF3C1 (General Transcription Factor IIIC Subunit 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA.

UniProtKB/Swiss-Prot for GTF3C1 Gene

  • Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.

Gene Wiki entry for GTF3C1 Gene

Additional gene information for GTF3C1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C1 Gene

Genomics for GTF3C1 Gene

GeneHancer (GH) Regulatory Elements for GTF3C1 Gene

Promoters and enhancers for GTF3C1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J027548 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.1 93 3.5 HDGF FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 KIAA0556 GTF3C1 IL21R-AS1 CLN3
GH16J027312 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +227.2 227157 19.6 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 IL4R FLJ21408 NSMCE1 GTF3C1 IL21R KIAA0556 GSG1L ENSG00000259940 KDM8 ENSG00000274092
GH16J027546 Enhancer 1.1 Ensembl ENCODE 0.7 +2.5 2482 0.9 ATF1 PKNOX1 ARNT TCF12 ZNF766 E2F8 FOS ATF7 NCOA1 ZNF184 IL21R-AS1 GTF3C1
GH16J027522 Enhancer 0.3 FANTOM5 1.7 +27.6 27592 0.3 IL21R KIAA0556 KDM8 GTF3C1 IL21R-AS1
GH16J027529 Enhancer 0.5 ENCODE 0.4 +19.6 19633 0.9 ZFHX2 GLIS1 FOS EGR2 GTF3C1 IL21R-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF3C1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTF3C1 gene promoter:
  • STAT3
  • C/EBPbeta
  • STAT1
  • AP-2gamma
  • FOXL1
  • CHOP-10
  • C/EBPalpha
  • NF-Y
  • CBF(2)

Genomic Locations for GTF3C1 Gene

Genomic Locations for GTF3C1 Gene
chr16:27,459,555-27,549,930
(GRCh38/hg38)
Size:
90,376 bases
Orientation:
Minus strand
chr16:27,470,876-27,561,251
(GRCh37/hg19)
Size:
90,376 bases
Orientation:
Minus strand

Genomic View for GTF3C1 Gene

Genes around GTF3C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C1 Gene

Proteins for GTF3C1 Gene

  • Protein details for GTF3C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12789-TF3C1_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 1
    Protein Accession:
    Q12789
    Secondary Accessions:
    • B2RP21
    • Q12838
    • Q6DKN9
    • Q9Y4W9

    Protein attributes for GTF3C1 Gene

    Size:
    2109 amino acids
    Molecular mass:
    238875 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2.
    SequenceCaution:
    • Sequence=AAA17985.1; Type=Frameshift; Positions=152, 189; Evidence={ECO:0000305}; Sequence=AAA85638.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential vector sequence at the N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF3C1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C1 Gene

Post-translational modifications for GTF3C1 Gene

  • Ubiquitination at Lys2105, isoforms=31162, isoforms=31143, isoforms=31128, isoforms=31090, isoforms=3724, Lys521, Lys427, Lys397, and isoforms=3254
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF3C1 Gene

No data available for DME Specific Peptides for GTF3C1 Gene

Domains & Families for GTF3C1 Gene

Gene Families for GTF3C1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GTF3C1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTF3C1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12789

UniProtKB/Swiss-Prot:

TF3C1_HUMAN :
  • Belongs to the TFIIIC subunit 1 family.
Family:
  • Belongs to the TFIIIC subunit 1 family.
genes like me logo Genes that share domains with GTF3C1: view

Function for GTF3C1 Gene

Molecular function for GTF3C1 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
GENATLAS Biochemistry:
general transcription factor IIIC,polypeptide 1,alpha subunit,box B binding,involved in recruitment of both GTF3B and RNA Pol3

Gene Ontology (GO) - Molecular Function for GTF3C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000995 contributes_to transcription factor activity, core RNA polymerase III binding IBA --
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding IBA --
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding IBA --
GO:0001007 obsolete transcription factor activity, RNA polymerase III transcription factor binding IBA --
GO:0003677 contributes_to DNA binding IC 17409385
genes like me logo Genes that share ontologies with GTF3C1: view
genes like me logo Genes that share phenotypes with GTF3C1: view

Animal Model Products

CRISPR Products

miRNA for GTF3C1 Gene

miRTarBase miRNAs that target GTF3C1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C1 Gene

Localization for GTF3C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF3C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with GTF3C1: view

Pathways & Interactions for GTF3C1 Gene

genes like me logo Genes that share pathways with GTF3C1: view

Gene Ontology (GO) - Biological Process for GTF3C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006359 regulation of transcription by RNA polymerase III IEA --
GO:0006383 transcription by RNA polymerase III IC 17409385
GO:0006384 transcription initiation from RNA polymerase III promoter IBA --
GO:0009303 rRNA transcription TAS 8164661
genes like me logo Genes that share ontologies with GTF3C1: view

No data available for SIGNOR curated interactions for GTF3C1 Gene

Drugs & Compounds for GTF3C1 Gene

(1) Additional Compounds for GTF3C1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF3C1: view

Transcripts for GTF3C1 Gene

mRNA/cDNA for GTF3C1 Gene

Unigene Clusters for GTF3C1 Gene

General transcription factor IIIC, polypeptide 1, alpha 220kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C1

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b ^ 30a · 30b ^ 31a · 31b · 31c ^ 32 ^ 33a · 33b ·
SP1:
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10: - - -
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22: -
SP23:

ExUns: 33c · 33d ^ 34a · 34b ^ 35 ^ 36a · 36b · 36c · 36d ^ 37 ^ 38a · 38b · 38c ^ 39 ^ 40a · 40b ^ 41a · 41b · 41c · 41d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14: -
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for GTF3C1 Gene

GeneLoc Exon Structure for
GTF3C1
ECgene alternative splicing isoforms for
GTF3C1

Expression for GTF3C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF3C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF3C1 Gene



Protein tissue co-expression partners for GTF3C1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF3C1 Gene:

GTF3C1

SOURCE GeneReport for Unigene cluster for GTF3C1 Gene:

Hs.371718

Evidence on tissue expression from TISSUES for GTF3C1 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with GTF3C1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C1 Gene

Orthologs for GTF3C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF3C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C1 34 33
  • 99.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C1 34 33
  • 83.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GTF3C1 34 33
  • 83.27 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
-- 34
  • 38 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gtf3c1 16 34 33
  • 79.96 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c1 33
  • 79.38 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF3C1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C1 34 33
  • 66.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c1 33
  • 58.65 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330568 33
  • 60.06 (n)
GTF3C1 34
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7099 34
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
Species where no ortholog for GTF3C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C1 Gene

ENSEMBL:
Gene Tree for GTF3C1 (if available)
TreeFam:
Gene Tree for GTF3C1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF3C1: view image

Paralogs for GTF3C1 Gene

(2) SIMAP similar genes for GTF3C1 Gene using alignment to 6 proteins:

  • TF3C1_HUMAN
  • H3BRD0_HUMAN
  • H3BU37_HUMAN
  • H3BU55_HUMAN
  • I3L1Z3_HUMAN
  • Q7Z7H4_HUMAN
genes like me logo Genes that share paralogs with GTF3C1: view

No data available for Paralogs for GTF3C1 Gene

Variants for GTF3C1 Gene

Sequence variations from dbSNP and Humsavar for GTF3C1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1060499746 likely-pathogenic, Abnormality of brain morphology 27,481,179(-) C/G/T coding_sequence_variant, missense_variant
rs1000080215 -- 27,510,167(-) C/T intron_variant
rs1000119041 -- 27,479,626(-) G/A intron_variant
rs1000120306 -- 27,476,369(-) G/A intron_variant
rs1000153841 -- 27,493,589(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTF3C1 Gene

Variant ID Type Subtype PubMed ID
dgv2829n100 CNV gain 25217958
esv2751555 CNV gain 17911159
nsv1059454 CNV gain 25217958
nsv1134516 CNV deletion 24896259
nsv833179 CNV loss 17160897

Variation tolerance for GTF3C1 Gene

Residual Variation Intolerance Score: 2.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF3C1 Gene

Human Gene Mutation Database (HGMD)
GTF3C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C1 Gene

Disorders for GTF3C1 Gene

Additional Disease Information for GTF3C1

No disorders were found for GTF3C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C1 Gene

Publications for GTF3C1 Gene

  1. Human transcription factor IIIC box B binding subunit. (PMID: 8127861) L'Etoile ND … Berk AJ (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22 58
  2. Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC. (PMID: 8164661) Lagna G … Roeder RG (Molecular and cellular biology 1994) 2 3 4 22 58
  3. Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery. (PMID: 19299493) de Planell-Saguer M … Mourelatos Z (Human molecular genetics 2009) 3 4 58
  4. Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates. (PMID: 18644873) Mertens C … Roeder RG (Molecular and cellular biology 2008) 3 22 58
  5. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H … Teichmann M (The Journal of biological chemistry 2007) 3 22 58

Products for GTF3C1 Gene

Sources for GTF3C1 Gene

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