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Aliases for GRM4 Gene

Aliases for GRM4 Gene

  • Glutamate Metabotropic Receptor 4 2 3 5
  • Glutamate Receptor, Metabotropic 4 2 3
  • GPRC1D 3 4
  • MGLUR4 3 4
  • Metabotropic Glutamate Receptor 4 3
  • MGlu4 3

External Ids for GRM4 Gene

Previous GeneCards Identifiers for GRM4 Gene

  • GC06M033991
  • GC06M034036
  • GC06M034097
  • GC06M033731
  • GC06M034039
  • GC06M034203
  • GC06M034891
  • GC06M035230
  • GC06M035725
  • GC06M034538
  • GC06M035558
  • GC06M036272
  • GC06M036645
  • GC06M036999
  • GC06M037350
  • GC06M037702

Summaries for GRM4 Gene

Entrez Gene Summary for GRM4 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for GRM4 Gene

GRM4 (Glutamate Metabotropic Receptor 4) is a Protein Coding gene. Diseases associated with GRM4 include Epilepsy, Idiopathic Generalized 10 and Schizophrenia. Among its related pathways are Circadian entrainment and GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and calcium-dependent protein binding. An important paralog of this gene is GRM8.

UniProtKB/Swiss-Prot for GRM4 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM4 Gene

  • Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.

Gene Wiki entry for GRM4 Gene

Additional gene information for GRM4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM4 Gene

Genomics for GRM4 Gene

GeneHancer (GH) Regulatory Elements for GRM4 Gene

Promoters and enhancers for GRM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I034145 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.4 +10.0 9985 0.9 SIN3A ZNF335 GLIS2 ZNF366 ZNF143 EGR2 ZNF362 ZBTB11 ZNF398 REST GRM4 MLN LEMD2 PIR53321
GH06I034153 Enhancer 1.1 Ensembl dbSUPER 550.8 +0.9 905 1.5 RB1 ZSCAN4 KLF17 ZNF76 SIN3A ZNF2 ZNF48 RAD21 GLIS2 ARID2 GRM4 RING1 PIR53321
GH06I034146 Promoter/Enhancer 1.1 EPDnew dbSUPER 550.4 +9.5 9515 0.1 CTCF MXI1 KLF1 GABPB1 VEZF1 MAX ZNF398 ELF1 GRM4 MLN LEMD2 PIR53321
GH06I034155 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +0.0 49 0.1 GRM4 PIR53321
GH06I034143 Enhancer 0.9 FANTOM5 dbSUPER 52.3 +11.8 11777 0.3 CTCF MXI1 PKNOX1 ZIC2 ZNF2 ZNF335 ZBTB48 PATZ1 ZNF600 EZH2 GRM4 MLN LEMD2 PACSIN1 PIR53321
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRM4 gene promoter:

Genomic Locations for GRM4 Gene

Genomic Locations for GRM4 Gene
chr6:34,018,643-34,155,622
(GRCh38/hg38)
Size:
136,980 bases
Orientation:
Minus strand
chr6:33,989,628-34,123,399
(GRCh37/hg19)

Genomic View for GRM4 Gene

Genes around GRM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM4 Gene

Proteins for GRM4 Gene

  • Protein details for GRM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14833-GRM4_HUMAN
    Recommended name:
    Metabotropic glutamate receptor 4
    Protein Accession:
    Q14833
    Secondary Accessions:
    • B3KVL9
    • B7Z1T9
    • B7Z1U6
    • F5GXM5
    • Q5SZ84
    • Q6ZMQ2

    Protein attributes for GRM4 Gene

    Size:
    912 amino acids
    Molecular mass:
    101868 Da
    Quaternary structure:
    • Interacts with PICK1.

    Alternative splice isoforms for GRM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRM4 Gene

Post-translational modifications for GRM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRM4 Gene

Domains & Families for GRM4 Gene

Gene Families for GRM4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q14833

UniProtKB/Swiss-Prot:

GRM4_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM4: view

Function for GRM4 Gene

Molecular function for GRM4 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Phenotypes From GWAS Catalog for GRM4 Gene

Gene Ontology (GO) - Molecular Function for GRM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IMP,IEA 8738157
GO:0008066 glutamate receptor activity IMP 8738157
genes like me logo Genes that share ontologies with GRM4: view
genes like me logo Genes that share phenotypes with GRM4: view

Animal Models for GRM4 Gene

MGI Knock Outs for GRM4:

Animal Model Products

miRNA for GRM4 Gene

miRTarBase miRNAs that target GRM4

Clone Products

  • Addgene plasmids for GRM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM4 Gene

Localization for GRM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRM4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 15102938
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IDA,TAS 15102938
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRM4 Gene

Pathways & Interactions for GRM4 Gene

genes like me logo Genes that share pathways with GRM4: view

Gene Ontology (GO) - Biological Process for GRM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 15102938
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IMP 15102938
GO:0007268 chemical synaptic transmission TAS 8738157
genes like me logo Genes that share ontologies with GRM4: view

No data available for SIGNOR curated interactions for GRM4 Gene

Drugs & Compounds for GRM4 Gene

(135) Drugs for GRM4 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
Spaglumic acid Approved Pharma 0
Fenobam Investigational Pharma Negative, Allosteric regulator 0
Kynurenic acid Investigational Pharma Agonist 4
L-AP4 Pharma Agonist Selective group III mGlu agonist 0

(6) Additional Compounds for GRM4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-SOP
Agonist

(5) Tocris Compounds for GRM4 Gene

Compound Action Cas Number
(RS)-PPG Potent, selective mGlu8 agonist 120667-15-4
(S)-3,4-DCPG Potent, selective mGlu8a agonist 201730-11-2
ACPT-I Group III mGlu agonist 194918-76-8
L-AP4 Selective group III mGlu agonist 23052-81-5
O-Phospho-L-serine Group III mGlu agonist 407-41-0

(105) ApexBio Compounds for GRM4 Gene

Compound Action Cas Number
(±)-LY 395756 852679-66-4
(±)-trans-ACPD 67684-64-4
(1S,3R)-ACPD 111900-32-4
(R)-3,4-DCPG 201730-10-1
(R)-3-Carboxy-4-hydroxyphenylglycine 13861-03-5
(RS)-3,4-DCPG 176796-64-8
(RS)-3,5-DHPG 19641-83-9
(RS)-3-Hydroxyphenylglycine 31932-87-3
(RS)-4-Carboxy-3-hydroxyphenylglycine 134052-66-7
(RS)-4-Carboxyphenylglycine 7292-81-1
(RS)-APICA 170847-18-4
(RS)-MCPG 146669-29-6
(RS)-MCPG disodium salt 1303994-09-3
(RS)-PPG 120667-15-4
(S)-3,4-DCPG 201730-11-2
(S)-3,5-DHPG 162870-29-3
(S)-3-Carboxy-4-hydroxyphenylglycine 55136-48-6
(S)-3-Hydroxyphenylglycine 71301-82-1
(S)-4-Carboxy-3-hydroxyphenylglycine 85148-82-9
(S)-4-Carboxyphenylglycine 134052-73-6
(S)-HexylHIBO 334887-48-8
(S)-MCPG 150145-89-4
2,4-Dihydroxyphenylacetyl-L-asparagine 111872-98-1
3-MATIDA 518357-51-2
ACDPP hydrochloride 37804-11-8
ACPT-I 194918-76-8
ACPT-II 195209-04-2
AIDA 168560-79-0
BINA 866823-73-6
CBiPES hydrochloride 856702-40-4
CDPPB 781652-57-1
CHPG Sodium salt 1303993-73-8
Cinnabarinic acid 606-59-7
CPCCOEt 179067-99-3
CPPG 183364-82-1
D-AP4 78739-01-2
DCB 6971-97-7
DCG IV 147782-19-2
Desmethyl-YM 298198 1177767-57-5
DFB 15332-10-2
DL-AP4 20263-07-4
DL-AP4 Sodium salt 1263093-79-3
DMeOB 40252-74-2
E4CPG 170846-89-6
EGLU 170984-72-2
Fenobam 57653-26-6
HexylHIBO 334887-43-3
JNJ 16259685 409345-29-5
Kynurenic acid 492-27-3
Kynurenic acid sodium salt 2439-02-3
L-AP4 23052-81-5
L-AP6 78944-89-5
L-BMAA hydrochloride 16012-55-8
L-CCG-l 117857-93-9
LY 2389575 hydrochloride 885104-09-6
LY 354740 176199-48-7
LY 379268 disodium salt
LY 456236 hydrochloride 338736-46-2
LY 487379 hydrochloride 353229-59-1
MAP4 157381-42-5
MFZ 10-7 1224431-15-5
ML 289 1382481-79-9
ML 337 1443118-44-2
MMPIP hydrochloride 479077-02-6
MNI 137 946619-21-2
MNI-caged-L-glutamate 295325-62-1
MSOP 66515-29-5
MSPG 169209-64-7
MTPG 169209-66-9
N-Acetylglycyl-D-glutamic acid 135701-69-8
NPEC-caged-(1S,3R)-ACPD 1315379-60-2
NPEC-caged-(S)-3,4-DCPG 1257323-85-5
NPEC-caged-LY 379268
NPS 2390 226878-01-9
O-Phospho-L-serine 407-41-0
PHCCC 179068-02-1
Ro 01-6128 302841-86-7
Ro 64-5229 246852-46-0
Ro 67-4853 302841-89-0
Ro 67-7476 298690-60-5
RuBi-Glutamate
Salsolinol-1-carboxylic acid 57256-34-5
SIB 1757 31993-01-8
SIB 1893 6266-99-5
Spaglumic acid 3106-85-2
S-Sulfo-L-cysteine sodium salt 7381-67-1
TC-N 22A 1314140-00-5
TCN 238 125404-04-8
UBP1112 339526-74-8
VU 0155041 1093757-42-6
VU 0155041 sodium salt 1259372-69-4
VU 0285683 327056-22-4
VU 0360172 hydrochloride 1309976-62-2
VU 0360223 1274859-33-4
VU 0361737 MGlu4 receptor allosteric modulator 1161205-04-4
VU 0364439 Positive allosteric mGluR-4 modulator 1246086-78-1
VU 0364770 61350-00-3
VU 1545 890764-63-3
VU 29 890764-36-0
Xanthurenic acid 59-00-7
YM 202074 299900-84-8
YM 230888 446257-23-4
YM 298198 hydrochloride 1216398-09-2
Z-Cyclopentyl-AP4 103439-17-4
γDGG 6729-55-1
genes like me logo Genes that share compounds with GRM4: view

Drug Products

Transcripts for GRM4 Gene

Unigene Clusters for GRM4 Gene

Glutamate receptor, metabotropic 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for GRM4

Alternative Splicing Database (ASD) splice patterns (SP) for GRM4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - -
SP2: - - - - - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: -
SP13:
SP14: - - - -
SP15:

ExUns: 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:

Relevant External Links for GRM4 Gene

GeneLoc Exon Structure for
GRM4
ECgene alternative splicing isoforms for
GRM4

Expression for GRM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRM4 Gene

mRNA differential expression in normal tissues according to GTEx for GRM4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x23.2) and Brain - Cerebellum (x22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM4 Gene



Protein tissue co-expression partners for GRM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRM4 Gene:

GRM4

SOURCE GeneReport for Unigene cluster for GRM4 Gene:

Hs.429018

mRNA Expression by UniProt/SwissProt for GRM4 Gene:

Q14833-GRM4_HUMAN
Tissue specificity: Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.

Evidence on tissue expression from TISSUES for GRM4 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GRM4: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM4 Gene

Orthologs for GRM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRM4 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRM4 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRM4 33 34
  • 93.26 (n)
cow
(Bos Taurus)
Mammalia GRM4 33 34
  • 93.13 (n)
rat
(Rattus norvegicus)
Mammalia Grm4 33
  • 89.99 (n)
mouse
(Mus musculus)
Mammalia Grm4 33 16 34
  • 89.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRM4 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRM4 34 33
  • 82.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRM4 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491626 33
  • 70.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10884 33
zebrafish
(Danio rerio)
Actinopterygii grm4 33 34
  • 75.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glu-RA 35
  • 45 (a)
CG30361 35
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea mgl-1 35
  • 37 (a)
Species where no ortholog for GRM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM4 Gene

ENSEMBL:
Gene Tree for GRM4 (if available)
TreeFam:
Gene Tree for GRM4 (if available)

Paralogs for GRM4 Gene

Paralogs for GRM4 Gene

(8) SIMAP similar genes for GRM4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GRM4: view

Variants for GRM4 Gene

Sequence variations from dbSNP and Humsavar for GRM4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000004732 -- 34,140,387(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000009201 -- 34,123,144(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000016850 -- 34,033,153(-) C/T intron_variant
rs1000047345 -- 34,136,657(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000061662 -- 34,122,930(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRM4 Gene

Variant ID Type Subtype PubMed ID
dgv3298n106 CNV tandem duplication 24896259
dgv3486e59 CNV duplication 20981092
esv22066 CNV loss 19812545
esv2518465 CNV deletion 19546169
esv2542860 CNV insertion 19546169
esv2657235 CNV deletion 23128226
esv2666805 CNV deletion 23128226
esv2674236 CNV deletion 23128226
esv2676995 CNV deletion 23128226
esv2731898 CNV deletion 23290073
esv2731899 CNV deletion 23290073
esv2731900 CNV deletion 23290073
esv2731901 CNV deletion 23290073
esv2731902 CNV deletion 23290073
esv2731903 CNV deletion 23290073
esv2731904 CNV deletion 23290073
esv3334053 CNV duplication 20981092
esv3567609 CNV deletion 23714750
esv3608630 CNV gain 21293372
esv3608652 CNV loss 21293372
esv3608653 CNV loss 21293372
esv7081 CNV loss 19470904
esv7787 CNV loss 19470904
esv990009 CNV deletion 20482838
nsv1077470 CNV duplication 25765185
nsv1120520 CNV tandem duplication 24896259
nsv1124047 CNV deletion 24896259
nsv1124938 CNV duplication 24896259
nsv1128924 CNV duplication 24896259
nsv1140616 CNV deletion 24896259
nsv1151076 CNV duplication 26484159
nsv478092 CNV novel sequence insertion 20440878
nsv509129 CNV insertion 20534489
nsv511878 CNV loss 21212237
nsv602843 CNV gain 21841781
nsv602861 CNV loss 21841781
nsv602862 CNV loss 21841781
nsv602863 CNV loss 21841781

Variation tolerance for GRM4 Gene

Residual Variation Intolerance Score: 2.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRM4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM4 Gene

Disorders for GRM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRM4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, idiopathic generalized 10
  • epilepsy, idiopathic generalized, susceptibility to, 10
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search GRM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRM4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM4 Gene

Publications for GRM4 Gene

  1. Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia. (PMID: 11525421) Ohtsuki T … Arinami T (Psychiatric genetics 2001) 3 4 22 44 58
  2. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PMID: 9473604) Wu S … Belagaje RM (Brain research. Molecular brain research 1998) 2 3 4 22 58
  3. Molecular characterization and localization of human metabotropic glutamate receptor type 4. (PMID: 8738157) Makoff A … Emson P (Brain research. Molecular brain research 1996) 2 3 4 22 58
  4. Role of GRM4 in idiopathic generalized epilepsies analysed by genetic association and sequence analysis. (PMID: 20338729) Muhle H … Sander T (Epilepsy research 2010) 3 22 44 58
  5. Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. (PMID: 19351574) Shibata H … Fukumaki Y (Psychiatry research 2009) 3 22 44 58

Products for GRM4 Gene

  • Addgene plasmids for GRM4

Sources for GRM4 Gene

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