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Aliases for TAGLN3 Gene

Aliases for TAGLN3 Gene

  • Transgelin 3 2 3 5
  • Neuronal Protein NP25 3 4
  • Neuronal Protein 22 3 4
  • NP22 3 4
  • NP25 3 4
  • Transgelin-3 3
  • NP24 3

External Ids for TAGLN3 Gene

Previous GeneCards Identifiers for TAGLN3 Gene

  • GC03P113201
  • GC03P111717
  • GC03P109092

Summaries for TAGLN3 Gene

GeneCards Summary for TAGLN3 Gene

TAGLN3 (Transgelin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is TAGLN2.

Gene Wiki entry for TAGLN3 Gene

Additional gene information for TAGLN3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN3 Gene

Genomics for TAGLN3 Gene

GeneHancer (GH) Regulatory Elements for TAGLN3 Gene

Promoters and enhancers for TAGLN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J111998 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +0.7 738 2.1 MXI1 PKNOX1 HLF SIN3A EBF1 MEF2B POLR2A CHD2 EZH2 TAGLN3 ABHD10 RFKP2
GH03J111858 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -136.1 -136054 8.6 SIN3A FEZF1 ZNF2 BRCA1 ZNF48 YY1 GLIS2 ATF7 RUNX3 SP3 PHLDB2 LOC105374040 ABHD10 PLCXD2 TAGLN3 PLCXD2-AS1 SLC9C1 GC03P111896
GH03J112004 Enhancer 0.6 FANTOM5 2.5 +6.1 6140 0.1 SP1 TFAP4 EGR1 NR2F1 NR2C1 NR2F6 HNF4A ABHD10 TAGLN3 SLC9C1 RFKP2
GH03J111978 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.4 -19.4 -19386 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 ABHD10 PLCXD2 PLCXD2-AS1 TAGLN3
GH03J112002 Enhancer 0.5 ENCODE 0.7 +4.0 3991 1.2 ZFHX2 JUND EGR1 HLF FOS EGR2 ABHD10 CD96 TAGLN3 RFKP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TAGLN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAGLN3 gene promoter:
  • GR
  • STAT5A
  • GR-alpha
  • Ik-3
  • AP-1

Genomic Locations for TAGLN3 Gene

Genomic Locations for TAGLN3 Gene
15,225 bases
Plus strand
15,225 bases
Plus strand

Genomic View for TAGLN3 Gene

Genes around TAGLN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN3 Gene

Proteins for TAGLN3 Gene

  • Protein details for TAGLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DN64
    • Q96A74

    Protein attributes for TAGLN3 Gene

    199 amino acids
    Molecular mass:
    22473 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF17189.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

neXtProt entry for TAGLN3 Gene

Post-translational modifications for TAGLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAGLN3 Gene

Domains & Families for TAGLN3 Gene

Gene Families for TAGLN3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TAGLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calponin family.
  • Belongs to the calponin family.
genes like me logo Genes that share domains with TAGLN3: view

Function for TAGLN3 Gene

Gene Ontology (GO) - Molecular Function for TAGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TAGLN3: view
genes like me logo Genes that share phenotypes with TAGLN3: view

Animal Model Products

CRISPR Products

miRNA for TAGLN3 Gene

miRTarBase miRNAs that target TAGLN3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAGLN3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAGLN3 Gene

Localization for TAGLN3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGLN3 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with TAGLN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TAGLN3 Gene

Pathways & Interactions for TAGLN3 Gene

SuperPathways for TAGLN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0007417 central nervous system development TAS 8015377
genes like me logo Genes that share ontologies with TAGLN3: view

No data available for Pathways by source and SIGNOR curated interactions for TAGLN3 Gene

Drugs & Compounds for TAGLN3 Gene

No Compound Related Data Available

Transcripts for TAGLN3 Gene

mRNA/cDNA for TAGLN3 Gene

Unigene Clusters for TAGLN3 Gene

Transgelin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TAGLN3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for TAGLN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAGLN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.8), Brain - Frontal Cortex (BA9) (x6.6), Brain - Cortex (x6.0), and Brain - Amygdala (x4.7).

Protein differential expression in normal tissues from HIPED for TAGLN3 Gene

This gene is overexpressed in Frontal cortex (20.0), Brain (15.3), and Fetal Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAGLN3 Gene

Protein tissue co-expression partners for TAGLN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGLN3 Gene:


SOURCE GeneReport for Unigene cluster for TAGLN3 Gene:


mRNA Expression by UniProt/SwissProt for TAGLN3 Gene:

Tissue specificity: Widely expressed in the brain. Expression is increased in the superior frontal cortex of alcoholics, but not in the motor cortex or cerebellum.

Evidence on tissue expression from TISSUES for TAGLN3 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with TAGLN3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGLN3 Gene

Orthologs for TAGLN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAGLN3 34 33
  • 99.5 (n)
(Bos Taurus)
Mammalia TAGLN3 34 33
  • 94.3 (n)
(Mus musculus)
Mammalia Tagln3 16 34 33
  • 93.63 (n)
(Rattus norvegicus)
Mammalia Tagln3 33
  • 92.96 (n)
(Canis familiaris)
Mammalia TAGLN3 34 33
  • 92.8 (n)
(Monodelphis domestica)
Mammalia TAGLN3 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia TAGLN3 34
  • 88 (a)
(Gallus gallus)
Aves TAGLN3 34 33
  • 80.74 (n)
(Anolis carolinensis)
Reptilia TAGLN3 34
  • 87 (a)
(Danio rerio)
Actinopterygii tagln3b 34 33
  • 71.52 (n)
tagln3a 34
  • 71 (a)
wufc80d07 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000748 33
  • 54.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Chd64 34
  • 44 (a)
(Caenorhabditis elegans)
Secernentea cpn-2 34 33
  • 46.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
CSA.10356 34
  • 42 (a)
Species where no ortholog for TAGLN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAGLN3 Gene

Gene Tree for TAGLN3 (if available)
Gene Tree for TAGLN3 (if available)
Evolutionary constrained regions (ECRs) for TAGLN3: view image

Paralogs for TAGLN3 Gene

Paralogs for TAGLN3 Gene

(5) SIMAP similar genes for TAGLN3 Gene using alignment to 4 proteins:

  • C9J5W6_HUMAN
  • H7C5N2_HUMAN
genes like me logo Genes that share paralogs with TAGLN3: view

Variants for TAGLN3 Gene

Sequence variations from dbSNP and Humsavar for TAGLN3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000053639 -- 112,003,400(+) A/G intron_variant
rs1000691106 -- 112,006,047(+) C/A intron_variant
rs1000708177 -- 112,014,304(+) A/G downstream_transcript_variant
rs1000806594 -- 112,006,309(+) T/G intron_variant
rs1000855173 -- 112,006,780(+) A/G intron_variant

Variation tolerance for TAGLN3 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAGLN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAGLN3 Gene

Disorders for TAGLN3 Gene

Additional Disease Information for TAGLN3

No disorders were found for TAGLN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAGLN3 Gene

Publications for TAGLN3 Gene

  1. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. (PMID: 11238712) Fan L … Wilce PA (Journal of neurochemistry 2001) 2 3 4 22 58
  2. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. (PMID: 8015377) Ren WZ … Liew CC (Brain research. Molecular brain research 1994) 2 3 22 58
  3. Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia. (PMID: 15781144) Ito M … Matsumoto I (Neuroscience letters 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58

Products for TAGLN3 Gene

Sources for TAGLN3 Gene

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